dbPTM

RIR2_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RIR2_DROME
UniProt AC	P48592
Protein Name	Ribonucleoside-diphosphate reductase subunit M2
Gene Name	RnrS
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	393
Subcellular Localization	Cytoplasm.
Protein Description	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides..
Protein Sequence	MASKENIADNMEKFSLKSPSKKILTDSTNNVRKMSIGHEANGQLAKESSTVNGIGKSANSLMEKSVTPFDPSLEPLLRENPRRFVIFPIQYHDIWQMYKKAEASFWTVEEVDLSKDLTDWHRLKDDERHFISHVLAFFAASDGIVNENLVERFSQEVQITEARCFYGFQIAMENVHSEMYSVLIDTYIRDPHQREYLFNAIETMPAVKRKADWALSWISSKSANFGERIIAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFAVLMFQHLVQRPKRERIIEIIRDAVAIEQEFLTDALPVNLIGMNCDLMSQYIEFVADRLLVELGVGKIYNTKNPFNFMEMISLDGKTNFFEKKVGEYQRMGVVSNPLDNVFTLDADF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MASKENIADN -----CCCHHHHHHH	38.92	19429919
15	Phosphorylation	ADNMEKFSLKSPSKK HHHHHHCCCCCCCCC	46.05	21082442
18	Phosphorylation	MEKFSLKSPSKKILT HHHCCCCCCCCCCCC	39.43	19429919
20	Phosphorylation	KFSLKSPSKKILTDS HCCCCCCCCCCCCCC	54.38	22668510
27	Phosphorylation	SKKILTDSTNNVRKM CCCCCCCCCCCEEEC	28.00	19429919
28	Phosphorylation	KKILTDSTNNVRKMS CCCCCCCCCCEEECH	33.35	19429919
35	Phosphorylation	TNNVRKMSIGHEANG CCCEEECHHCCHHCC	28.58	19429919
48	Phosphorylation	NGQLAKESSTVNGIG CCCCCCCCCCCCCCC	30.51	22817900
56	Acetylation	STVNGIGKSANSLME CCCCCCCHHHHHHHH	44.46	21791702
57	Phosphorylation	TVNGIGKSANSLMEK CCCCCCHHHHHHHHC	27.72	25749252
60	Phosphorylation	GIGKSANSLMEKSVT CCCHHHHHHHHCCCC	28.89	22817900
65	Phosphorylation	ANSLMEKSVTPFDPS HHHHHHCCCCCCCCC	20.23	22817900
67	Phosphorylation	SLMEKSVTPFDPSLE HHHHCCCCCCCCCCH	25.90	19060867
373	Phosphorylation	FEKKVGEYQRMGVVS HHHHHHHHHHCCEEC	8.76	22817900
380	Phosphorylation	YQRMGVVSNPLDNVF HHHCCEECCCCCCEE	30.26	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RIR2_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RIR2_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RIR2_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
TULP_DROME	ktub	physical	22036573

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RIR2_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18, AND MASSSPECTROMETRY.	18327897 [Abstract]