| UniProt ID | RAGP1_DROME | |
|---|---|---|
| UniProt AC | Q9VIW3 | |
| Protein Name | Ran GTPase-activating protein | |
| Gene Name | RanGAP | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 596 | |
| Subcellular Localization | Cytoplasm. | |
| Protein Description | GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state (By similarity). Trans-acting factor necessary for meiotic distortion. Distortion is only seen in individuals that carry the RanGAP tandem duplication and express a RanGAP truncated protein. Binding of truncated RanGAP product to the Responder(RSP) locus initiates events that lead to sperm dysfunction.. | |
| Protein Sequence | MSTFNFASMAAQLGQEQGISFENKVLSWNTAADVQDVVDALNKQTTVHYLNLDGNTLGVEAAKAIGEGLKRHPEFRKALWKNMFTGRLISEIPEALKHLGAALIVAGAKLTVLDLSDNALGPNGMRGLEELLRSPVCYSLQELLLCNCGLGPEGGSMLSRALIDLHANANKAGFPLQLRVFIGSRNRLEDAGATEMATAFQTLKTFEEIVLEQNSIYIEGVEALAESFKHNPHLRVLNMNDNTLKSEGAEKIAEALPFLPLLREMSFGDCLIKTNGAYHFGEALERGNERLEVIDLGFNEINSDGGLVLVNAMGNKPKLRILNLDGNSFGEEGSEKIISEMSKLPTAAALQPFQHQEEEDLEDEYQADKQDADYEEEEEVHEHANDTTEEADEDSEGDEDDEEDEGDEEYSNVAEETAYVTTNAYTTKLFNDTTNSMASETFAVANKTISQKCTPEKFCLSQKPCSQEDFDSLDMDNKLEALQSIVNQFTGDNHLLLLVFTTLKCAHLSQSSKAALDLAVSLYQATFDYAIKTKQETRVLNYVLMQLRLLPCKEVFHSDYDVKNCRFALREALKQPTFANDNIKNSFKTFLEGAES | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 433 | Phosphorylation | TTKLFNDTTNSMASE HHHHCCCCCCCHHHH | 29.05 | 19429919 | |
| 434 | Phosphorylation | TKLFNDTTNSMASET HHHCCCCCCCHHHHH | 28.32 | 19429919 | |
| 436 | Phosphorylation | LFNDTTNSMASETFA HCCCCCCCHHHHHHH | 17.40 | 19429919 | |
| 439 | Phosphorylation | DTTNSMASETFAVAN CCCCCHHHHHHHHHC | 28.64 | 19429919 | |
| 441 | Phosphorylation | TNSMASETFAVANKT CCCHHHHHHHHHCCC | 17.88 | 19429919 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RAGP1_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RAGP1_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RAGP1_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| NXT1_DROME | Nxt1 | physical | 22036573 | |
| AIFM1_DROME | AIF | physical | 22036573 | |
| PIWI_DROME | piwi | genetic | 23267055 | |
| AUB_DROME | aub | genetic | 23267055 | |
| ZUC_DROME | zuc | genetic | 23267055 | |
| CUFF_DROME | cuff | genetic | 23267055 | |
| RCC1_DROME | Rcc1 | genetic | 11702947 | |
| RAN_DROME | Ran | genetic | 11702947 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-433; THR-434 ANDSER-436, AND MASS SPECTROMETRY. | |
