| UniProt ID | RCC1_DROME | |
|---|---|---|
| UniProt AC | P25171 | |
| Protein Name | Regulator of chromosome condensation | |
| Gene Name | Rcc1 | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 547 | |
| Subcellular Localization | Nucleus. Cytoplasm. Becomes dispersed throughout the cytoplasm during mitosis. Is associated with chromatin throughout mitosis. | |
| Protein Description | Promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds to chromatin.. | |
| Protein Sequence | MPRRKALTNNNNAGEAEQQPPKAKRARIAFHLELPKRRTVLGNVLVCGNGDVGQLGLGEDILERKRLSPVAGIPDAVDISAGGMHNLVLTKSGDIYSFGCNDEGALGRDTSEDGSESKPDLIDLPGKALCISAGDSHSACLLEDGRVFAWGSFRDSHGNMGLTIDGNKRTPIDLMEGTVCCSIASGADHLVILTTAGKVFTVGCAEQGQLGRLSERSISGEGRRGKRDLLRPTQLIITRAKPFEAIWATNYCTFMRESQTQVIWATGLNNFKQLAHETKGKEFALTPIKTELKDIRHIAGGQHHTVILTTDLKCSVVGRPEYGRLGLGDVKDVVEKPTIVKKLTEKIVSVGCGEVCSYAVTIDGKLYSWGSGVNNQLGVGDGDDELEPIVVVSKNTQGKHMLLASGGGQHAIFLVKADKQDQKENVPVKVSGSSSISKKDKTPPQDNVDKEAENVDKQEQKENLPAKASTSSKKNKTPPQDNADKEAENVDKQEQKENLPAKASTSSKKIKTPPQDDAAEEVEEESAQEPTPKKAKKPAAKRGGKKT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 68 | Phosphorylation | ILERKRLSPVAGIPD HHHHCCCCCCCCCCC | 22.74 | 22817900 | |
| 281 | Acetylation | LAHETKGKEFALTPI HHHHHCCCCEEECCC | 51.74 | 21791702 | |
| 286 | Phosphorylation | KGKEFALTPIKTELK CCCCEEECCCCHHHH | 21.38 | 22817900 | |
| 331 | Ubiquitination | RLGLGDVKDVVEKPT CCCCCCHHHHHHCCH | 49.93 | 31113955 | |
| 433 | Phosphorylation | VPVKVSGSSSISKKD CCEEEECCCCCCCCC | 17.26 | 29892262 | |
| 435 | Phosphorylation | VKVSGSSSISKKDKT EEEECCCCCCCCCCC | 32.36 | 27794539 | |
| 442 | Phosphorylation | SISKKDKTPPQDNVD CCCCCCCCCCCCCCC | 50.78 | 19429919 | |
| 477 | Phosphorylation | TSSKKNKTPPQDNAD CCCCCCCCCCCCCHH | 49.98 | 19429919 | |
| 512 | Phosphorylation | TSSKKIKTPPQDDAA CCCCCCCCCCCCCHH | 43.61 | 21082442 | |
| 526 | Phosphorylation | AEEVEEESAQEPTPK HHHHHHHHCCCCCCH | 38.23 | 19429919 | |
| 531 | Phosphorylation | EESAQEPTPKKAKKP HHHCCCCCCHHCCCC | 47.16 | 21082442 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RCC1_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RCC1_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RCC1_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| ZFH1_DROME | zfh1 | physical | 14605208 | |
| E2F2_DROME | E2f2 | physical | 14605208 | |
| SERC_DROME | CG11899 | physical | 14605208 | |
| CHDM_DROME | Mi-2 | genetic | 25501812 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-286; THR-512; SER-526AND THR-531, AND MASS SPECTROMETRY. | |
