dbPTM

ZFH1_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ZFH1_DROME
UniProt AC	P28166
Protein Name	Zinc finger protein 1
Gene Name	zfh1
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	1054
Subcellular Localization	Nucleus .
Protein Description	Involved in the development of the embryonic central nervous system, embryonic mesoderm and adult musculature..
Protein Sequence	MLSCLAPSSSRFGQEDTIIQQSMPSTSPFAMQFPSLASTLLHHNQSPKHSNPGSSGIQDAHPNQPGAAADAFLVKCTQCHKRFPEYQSLSEHIASEHPHDKLNCGAAQPESDAEDEQSNMSGSSRRYAKSPLASNNNSSTANANNNSTSSQSMNNNSELAKNHNSANKMSPMCSPGSLTPGDLFAQLQHPPPQLPPHLHAQFMAAAASLAMQSARTASSPSQQQQQQLQQQQQLQQQQQHQMAMQQLLPPQLPGSNSSVGSNSAYDLDLSAPRSTSSPGSTTGDLSGAYPCMQCTASFASREQLEQHEQLHSPCGPAAVSNVSQTCRICHKAFANVYRLQRHMISHDESALLRKFKCKECDKAFKFKHHLKEHVRIHSGEKPFGCDNCGKRFSHSGSFSSHMTSKKCISMGLKLNNNRALLKRLEKSPGSASSASRRSPSDHGKGKLPEQPSLPGLPHPMSYFASDAQVQGGSAAPAPFPPFHPNYMNAALLAFPHNFMAAAAGLDPRVHPYSIQRLLQLSAAGQQQREEEREEQQKQQQHDEEETPDEPKLVMDIEEPETKEMAPTPEATEAATPIKREESREASPDPESYRSSSQAIKQEQEPLNVAEERQTPVEEHAPVEHAADLRCSRCSKQFNHPTELVQHEKVLCGLIKEELEQHFQQQQATSFALASASEEDEEDEEMDVEEEPRQESGERKVRVRTAINEEQQQQLKQHYSLNARPSRDEFRMIAARLQLDPRVVQVWFQNNRSRERKMQSFQNNQAAGAAPPMPIDSQASLTREDQPLDLSVKRDPLTPKSESSPPYIAPPSGEALNPEAINLSRKFSTSASMSPASISPSSAAALYFGAAPPPSPPNSQLDSTPRSGQAFPGLPPYMLPMSLPMEALFKMRPGGDFASNHALMNSIKLPDYRGTSLSPGGSEKRSWRDDDSRISHEDEFGAGVLMPPKPRRGKAETHGHAGDPDLPYVCDQCDKAFAKQSSLARHKYEHSGQRPYQCIECPKAFKHKHHLTEHKRLHSGEKPFQCSKCLKRFSHSGSYSQHMNHRYSYCKPYRE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
111	Phosphorylation	CGAAQPESDAEDEQS CCCCCCCCCHHHHHH	49.13	29892262
312	Phosphorylation	EQHEQLHSPCGPAAV HHHHHHCCCCCHHHH	30.40	21082442
427	Phosphorylation	LLKRLEKSPGSASSA HHHHHHCCCCCCCCC	25.72	27626673
438	Phosphorylation	ASSASRRSPSDHGKG CCCCCCCCCCCCCCC	27.87	19429919
440	Phosphorylation	SASRRSPSDHGKGKL CCCCCCCCCCCCCCC	43.41	19429919
546	Phosphorylation	QQHDEEETPDEPKLV HHCCCCCCCCCCCEE	39.04	19429919
567	Phosphorylation	ETKEMAPTPEATEAA CCCCCCCCHHHHHCC	24.99	19429919
571	Phosphorylation	MAPTPEATEAATPIK CCCCHHHHHCCCCCC	25.21	19429919
575	Phosphorylation	PEATEAATPIKREES HHHHHCCCCCCHHHH	32.37	19429919
582	Phosphorylation	TPIKREESREASPDP CCCCHHHHHHCCCCH	30.57	19429919
586	Phosphorylation	REESREASPDPESYR HHHHHHCCCCHHHHH	25.69	19429919
614	Phosphorylation	NVAEERQTPVEEHAP CHHHHCCCCHHHHCC	35.21	22817900
797	Phosphorylation	SVKRDPLTPKSESSP EECCCCCCCCCCCCC	33.77	27626673
914	Phosphorylation	KLPDYRGTSLSPGGS CCCCCCCCCCCCCCC	19.93	19429919
915	Phosphorylation	LPDYRGTSLSPGGSE CCCCCCCCCCCCCCC	29.67	19429919
917	Phosphorylation	DYRGTSLSPGGSEKR CCCCCCCCCCCCCCC	22.67	19429919
921	Phosphorylation	TSLSPGGSEKRSWRD CCCCCCCCCCCCCCC	45.95	19429919
931	Phosphorylation	RSWRDDDSRISHEDE CCCCCCCCCCCCCCC	38.21	19429919
934	Phosphorylation	RDDDSRISHEDEFGA CCCCCCCCCCCCCCC	21.51	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ZFH1_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ZFH1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ZFH1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EWG_DROME	ewg	physical	14605208
DRC7_DROME	lobo	physical	14605208
EVE_DROME	eve	genetic	24560702
EVE_DROME	eve	genetic	10375513
TIN_DROME	tin	genetic	11076678

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ZFH1_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-582; SER-586 ANDSER-934, AND MASS SPECTROMETRY.	18327897 [Abstract]