EWG_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EWG_DROME
• UniProt AC: Q24312
• Protein Name: DNA-binding protein Ewg
• Gene Name: ewg
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 733
• Subcellular Localization: Nucleus . Not in nucleolus.
• Protein Description: May function as a positive regulator of transcription in developing and differentiated neurons, regulating common aspects of neuronal differentiation and maintenance. Requirement in the CNS may be higher than in the peripheral system. Vital for development of the indirect flight muscles..
• Protein Sequence: MATTSYRLVVAPAGSQRSSTGNVVVTTTSSGSHSSNGANGGTGGTSAGSSTLGSGLNVTTITATSGGQLQSAGNTSQSNGTTYKIEMLEEDIQSLGSDDDDEDLISSDGSLYEGDLGSMPVNDDVAHQLAAAGPVGVAAAAAIASSKKRKRPHCFETNPSVRKRQQNRLLRKLRAIIYEFTGRVGKQAVVLVATPGKPNTSYKVFGAKPLEDVLRNLKNIVMDELDNALAQQAPPPPQDDPSLFELPGLVIDGIPTPVEKMTQAQLRAFIPLMLKYSTGRGKPGWGRESTRPPWWPKELPWANVRMDARSEDDKQKISWTHALRKIVINCYKYHGREDLLPTFADDEDKVNALISQSGDEDEDMELSNPPTIHTVTTMTPPTGNSNQPQQVNVVKINSAGTVITTHTAQSNTPAPTIIQSTNNQHVTTTATLPASTKIEICQAPAQNQQHHQHHQTHLPNAVHIQPVAGGQPQTIQLTTASGTATATAVQTTAAAVSAAQAHAHSQSQAHSQSSANQTVTAQQIANAQVCIEPITLSDVDYTTQTVLSQNADGTVSLIQVDPNNPIITLPDGTTAQVQGVATLHQGEGGATIQTVQSLTDVNGHENMTVDLTETQDGQIYITTEDGQGYPVSVSNVISVPVSMYQSVMANVQQIQTNSDGTVCLAPMQVENGDQLETITMSPGMHQMMIQGGPGQEPQLVQVVSLKDATLLSKAMEAINSGNVKSEDTIIMEQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
97	Phosphorylation	EDIQSLGSDDDDEDL HHHHHCCCCCCCCCC	43.06	-
110	Phosphorylation	DLISSDGSLYEGDLG CCCCCCCCEEECCCC	32.54	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
97	S	Phosphorylation	Kinase	CK2	-	Uniprot
110	S	Phosphorylation	Kinase	CK2	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EWG_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EWG_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CRN_DROME	crn	physical	14605208
MTND_DROME	CG32068	physical	14605208
NU301_DROME	E(bx)	physical	14605208
ESCA_DROME	esg	physical	14605208
IF4E_DROME	eIF-4E	physical	14605208
SNP25_DROME	Snap25	physical	14605208
THIO1_DROME	dhd	physical	14605208
OPS1_DROME	ninaE	physical	14605208
KLC_DROME	Klc	physical	14605208
CCNB3_DROME	CycB3	physical	14605208
HGH1_DROME	CG6073	physical	14605208
GRPE_DROME	Roe1	physical	14605208
RS3_DROME	RpS3	physical	14605208
PDI_DROME	Pdi	physical	14605208
CTBP_DROME	CtBP	physical	14605208
ZEST_DROME	z	physical	14605208
RS8_DROME	RpS8	physical	14605208
EF1A1_DROME	Ef1alpha48D	physical	14605208

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.