GRPE_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GRPE_DROME
• UniProt AC: P48604
• Protein Name: GrpE protein homolog, mitochondrial
• Gene Name: Roe1
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 213
• Subcellular Localization: Mitochondrion matrix .
• Protein Description: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (By similarity)..
• Protein Sequence: MSAKAALPLQMFGRRLVHLRSSVTSQNMSALRLYSTEKQPEEATEQKATESSPEVEKLTKELAAAKEQNAELMDKYKRSLADSENMRNRLNKQISDAKIFGIQSFCKDLLEVADTLGHATQAVPKDKLSGNADLKNLYEGLTMTRASLLQVFKRHGLEPLDPINQKFDPNQHEALFQKEDKTVEPNTVVEVTKLGYKLHERCIRPALVGVSKC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
57	Acetylation	ESSPEVEKLTKELAA CCCHHHHHHHHHHHH	67.63	21791702
60	Acetylation	PEVEKLTKELAAAKE HHHHHHHHHHHHHHH	62.25	21791702
75	Acetylation	QNAELMDKYKRSLAD HHHHHHHHHHHHHHC	38.41	21791702

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GRPE_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GRPE_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GRPE_DROME !!

Protein-Protein Interaction

Oops, there are no PPI records of GRPE_DROME !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.