CTBP_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CTBP_DROME
• UniProt AC: O46036
• Protein Name: C-terminal-binding protein
• Gene Name: CtBP
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 476
• Subcellular Localization: Nucleus.
• Protein Description: Corepressor targeting diverse transcription regulators. Hairy-interacting protein required for embryonic segmentation and hairy-mediated transcriptional repression..
• Protein Sequence: MDKNLMMPKRSRIDVKGNFANGPLQARPLVALLDGRDCSIEMPILKDVATVAFCDAQSTSEIHEKVLNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGTDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVREAAHGCARIRGDTLGLVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGIDKSLGLTRVYTLQDLLFQSDCVSLHCTLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDETLALALKQGRIRAAALDVHENEPYNVFQGALKDAPNLICTPHAAFFSDASATELREMAATEIRRAIVGNIPDVLRNCVNKEYFMRTPPAAAAGGVAAAVYPEGALHHRAHSTTPHDGPHSTTNLGSTVGGGPTTVAQAAAAAVAAAAAAALLPSPVPSHLSPQVGGLPLGIVSSQSPLSAPDPNNHLSSSIKTEVKAESTEAP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
355	Phosphorylation	RNCVNKEYFMRTPPA HHHCCHHHHHCCCHH	12.32	19060867
355 (in isoform 2)	Phosphorylation	-	12.32	21082442
359	Phosphorylation	NKEYFMRTPPAAAAG CHHHHHCCCHHHHHC	23.10	21082442
359 (in isoform 2)	Phosphorylation	-	23.10	29892262

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CTBP_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CTBP_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CTBP_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GIANT_DROME	gt	physical	14605208
BCCIP_DROME	CG9286	physical	14605208
DISC_DROME	disco	physical	14605208
SNAI_DROME	sna	physical	17972097
KNIR_DROME	kni	physical	17972097
HAIR_DROME	h	physical	10973955
USH_DROME	ush	genetic	18992810
PNR_DROME	pnr	genetic	18992810
SNAI_DROME	sna	physical	9525852
ISWI_DROME	Iswi	physical	22426536
HAIR_DROME	h	physical	21343912
HAIR_DROME	h	physical	9524128
HAIR_DROME	h	physical	9892668
DIAP1_DROME	th	physical	22138398
KNIR_DROME	kni	physical	9525852
CTBP_DROME	CtBP	physical	21468031
CTBP_DROME	CtBP	physical	9524128
HLES_DROME	H	physical	11378391
HLES_DROME	H	physical	12154126
DANR_DROME	danr	physical	20730908
DAN_DROME	dan	physical	20730908
PAX6_DROME	ey	physical	20730908
GFI1_DROME	sens	physical	25404315

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.