DANR_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DANR_DROME
• UniProt AC: Q9VBW9
• Protein Name: Protein distal antenna-related {ECO:0000303|PubMed:12571108}
• Gene Name: danr {ECO:0000312|EMBL:AAF56408.1, ECO:0000312|FlyBase:FBgn0039283}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 419
• Subcellular Localization: Nucleus .
• Protein Description: Probable transcription factor with a role in the retinal determination (RD) network. Regulates ato expression and is required for normal R8 induction and differentiation. Danr appears to repress Dan expression, but Dan is required for Danr expression anterior to the morphogenetic furrow (MF). Dan and Danr lie downstream of so and require dac function for highest levels of expression. Contributes to differentiation of antenna-specific characteristics; effector gene that acts downstream of homothorax (hth), Distal-less (Dll), cut (ct) and spineless (ss) genes to control differentiation of distal antennal structures..
• Protein Sequence: MDISAYQHMNIRMSTRGKRPLRNLTPNDKVRAIQRIHNGETKASVSRDIGVPESTLRGWCKNEQKLRFMCRQLGPDHLGLDTPPEKRAKFELQLQLPPKFVALPPNYEELGFGALPYSPADYPVQNESLLEKLSLVEFVKKNGGLHPEGALHPGQAGVMDYSNNMLHQLNLLALLNSKLTPQTADVLVDAQPKSEDNKVIDSPAASEDYSKNNYPLLSVKNWAKDPAKRVNSANQPEQVNDKNNNALEANSSAPQALVTEQAKTPMFSDTTMPLLPAPFPNPADLAPVIAPVTPANAPPTGTDNQGAALLDWCKLFNASLNFLAFAAAAASMQPGGGGPGGPSYNPNQMASGGSEPDLETYPFNEALLKRLSPLAHSEASNESYCDSEPEDLSVRSCASKASSRSHTPDKSVGSSDAEQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
232	Phosphorylation	DPAKRVNSANQPEQV CHHHHCCCCCCHHHC	26.24	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DANR_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DANR_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DANR_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CTBP_DROME	CtBP	physical	14605208
TIM9_DROME	Tim9a	physical	14605208
EXOC4_DROME	Sec8	physical	14605208
GSTS1_DROME	GstS1	physical	14605208
ZW10_DROME	Zw10	physical	14605208
NOTCH_DROME	N	genetic	12921746
DAN_DROME	dan	genetic	12921746
DAN_DROME	dan	physical	20730908

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.