dbPTM

DAN_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DAN_DROME
UniProt AC	Q9VBW6
Protein Name	Protein distal antenna {ECO:0000303\|PubMed:12571108}
Gene Name	dan {ECO:0000312\|EMBL:AAF56411.2, ECO:0000312\|FlyBase:FBgn0039286}
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	678
Subcellular Localization	Nucleus .
Protein Description	Probable transcription factor with a role in the retinal determination (RD) network. Regulates ato expression and is required for normal R8 induction and differentiation. Danr appears to repress Dan expression, but Dan is required for Danr expression anterior to the morphogenetic furrow (MF). Dan and Danr lie downstream of so and require dac function for highest levels of expression. Contributes to differentiation of antenna-specific characteristics; effector gene that acts downstream of homothorax (hth), Distal-less (Dll), cut (ct) and spineless (ss) genes to control differentiation of distal antennal structures..
Protein Sequence	MNIRMGTKGKRPLRSLTPRDKIHAIQRIHDGESKASVARDIGVPESTLRGWCKNEDKLRFMSRQSATDNLCADALGDKMDGGGGGGGGAGGGGLLGPPEKRQRLDGALPLNFSNKLKFDELAFKRSPLNGLDYSTNKNLADLGYNGLPVDYAAFNGGVKAKVFGADINRPAADPSLNAISPLSSLTHLSGLTGISQSPLAISFNELTTNLNLLAQLNPGLAAMSGLNSFPAGAGNLRTPKPSGQTPLQVQSPRSDSGDRSAQGLSVKNWAKQKPGEGQGSLNLSIKNEGKGGDIKSPSPSIAPSQMGGPMTLSNLAEDPLLYWLKSQQTMLGLNPLYPPTIPMGVTSPPIRSSTPQHMSQLAQTPPIPSAPLTPSSTPSGSLDEKNAAWYNWCKAFGASLHTLNPNAATLAALQANQLQQQVATTAAEGGSMGDPSNILYSHLTKETETPSVRSLSSNEQNPEADEATETDLDGEVEPEASGKPEDLSAAGKVMTPSQSPIAHSSGSRSPEPKAKTKTPETTNSTSECKKILDNMLFKMGGMEATGPLMPEQGSSESEGSFQDTSNPHTNNNDVSASNNNNNNNSNKTDEEEKAKYLDCTADEDIEAIRHGEKFLQWLENCSNPRVTAVQLMQLRFLIAAIKSGNETPMIEKSALPEDSEEHAAEEEGSGRGKSRRRK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
251	Phosphorylation	QTPLQVQSPRSDSGD CCCCEEECCCCCCCC	24.35	22817900
254	Phosphorylation	LQVQSPRSDSGDRSA CEEECCCCCCCCCCC	39.24	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DAN_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DAN_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DAN_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RUXE_DROME	SmE	physical	14605208
DANR_DROME	danr	genetic	12921746
CTBP_DROME	CtBP	physical	20730908
DANR_DROME	danr	physical	20730908
PAX6_DROME	ey	physical	20730908

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DAN_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-251 AND SER-254, ANDMASS SPECTROMETRY.	18327897 [Abstract]