| UniProt ID | HLES_DROME | |
|---|---|---|
| UniProt AC | Q02308 | |
| Protein Name | Protein hairless | |
| Gene Name | H | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 1077 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Is a potent antagonist of neurogenic gene activity during sensory organ development. The expression of distinct cell fates by the trichogen (shaft) / tormogen (socket) sister cell pair depends on the level of H activity. A certain threshold level of H activity is required, below which both sister cells adopt the tormogen fate.. | |
| Protein Sequence | MALLNDVTSVAECNRQTTMTDEHKSNINSNSSHSSNNNNNGSSSNNDNNSNDDAASSSNSKNNNTSNESSHSNNNTSSIIAEAAAKFLLKNGLNGSSSTSYPPLPPPLPANLSRTTTPTTTTTPSSSSSTASNGFLPHAKTPKSSSIMAASAAVAASVVGATASKPTIDVLGGVLDYSSLGGAATGSLPTTAVVAAAAGTAKIGKGSNSGGSFDMGRTPISTHGNNSWGGYGGRLQFFKDGKFILELARSKDGDKSGWVSVTRKTFRPPSAATSATVTPTSAVTTAYPKNENSTSLSFSDDNSSIQSSPWQRDQPWKQSRPRRGISKELSLFFHRPRNSTLGRAALRTAARKRRRPHEPLTTSEDQQPIFATAIKAENGDDTLKAEAAEAVEIENVAVADTTTNEIKIEKPDTIKGEDDAERLEKEPKKAVSDDSESKEASPGQQVEPQPKDETVDVEMKMNTSEDEEPMTELPRITNAVNGDLNGDLKASIGKPKSKPKPKAKLSSIIQKLIDSVPARLEQMSKTSAVIASTTTSSDRIGGGLSHALTHKVSPPSSATAAGRLVEYHTQHVSPRKRILREFEKVSLEDNGCVNNGSGGASSGGAGGKRSRAKGTSTSSPAGKASPMNLAPPQGKPSPSPGSSSSSTSPATLSTQPTRLNSSYSIHSLLGGSSGSGSSSFSSSGKKCGDHPAAIISNVHHPQHSMYQPSSSSYPRALLTSPKSPDVSGSNGGGGKSPSHTGTKKRSPPYSAGSPVDYGHSFYRDPYAGAGRPSTSGSASQDLSPPRSSPASPATTPRTVPKKTASIRREFASPSASSSSCPSPGDRSASPPERRHMQQQPHLQRSSPLHYYMYPPPPQVNGNGSAGSPTSAPPTSNSSAAAVAAAAAAAAAYIPSPSIYNPYISTLAALRHNPLWMHHYQTGASPLLSPHPQPGGSAAAAAAAAAARLSPQSAYHAFAYNGVGAAVAAAAAAAAFGQPAPSPHTHPHLAHPHQHPHPAALTTHHSPAHLATPKLTDSSTDQMSATSSHRTASTSPSSSSASASSSAATSGASSSAMFHTSSLRNEQSSDLPLNLSKH | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 372 | Phosphorylation | DQQPIFATAIKAENG CCCCEEEEEEEECCC | 20.40 | 22668510 | |
| 441 | Phosphorylation | DSESKEASPGQQVEP CCCCCCCCCCCCCCC | 30.56 | 19060867 | |
| 464 | Phosphorylation | VEMKMNTSEDEEPMT EEEECCCCCCCCCCC | 37.74 | 22668510 | |
| 545 | Phosphorylation | DRIGGGLSHALTHKV CCCCCCHHHHHHCCC | 15.25 | 19429919 | |
| 549 | Phosphorylation | GGLSHALTHKVSPPS CCHHHHHHCCCCCCC | 22.04 | 19429919 | |
| 553 | Phosphorylation | HALTHKVSPPSSATA HHHHCCCCCCCCCHH | 35.58 | 19429919 | |
| 556 | Phosphorylation | THKVSPPSSATAAGR HCCCCCCCCCHHHHH | 35.67 | 19429919 | |
| 557 | Phosphorylation | HKVSPPSSATAAGRL CCCCCCCCCHHHHHH | 35.10 | 19429919 | |
| 559 | Phosphorylation | VSPPSSATAAGRLVE CCCCCCCHHHHHHHH | 20.98 | 19429919 | |
| 573 | Phosphorylation | EYHTQHVSPRKRILR HHHHHCCCHHHHHHH | 19.50 | 22668510 | |
| 720 | Phosphorylation | YPRALLTSPKSPDVS CCCEEECCCCCCCCC | 30.24 | 22817900 | |
| 723 | Phosphorylation | ALLTSPKSPDVSGSN EEECCCCCCCCCCCC | 29.71 | 22817900 | |
| 736 | Phosphorylation | SNGGGGKSPSHTGTK CCCCCCCCCCCCCCC | 34.60 | 21082442 | |
| 738 | Phosphorylation | GGGGKSPSHTGTKKR CCCCCCCCCCCCCCC | 40.55 | 21082442 | |
| 742 | Phosphorylation | KSPSHTGTKKRSPPY CCCCCCCCCCCCCCC | 34.25 | 21082442 | |
| 746 | Phosphorylation | HTGTKKRSPPYSAGS CCCCCCCCCCCCCCC | 38.82 | 19429919 | |
| 753 | Phosphorylation | SPPYSAGSPVDYGHS CCCCCCCCCCCCCCC | 22.82 | 22817900 | |
| 783 | Phosphorylation | GSASQDLSPPRSSPA CCCCCCCCCCCCCCC | 40.94 | 21082442 | |
| 787 | Phosphorylation | QDLSPPRSSPASPAT CCCCCCCCCCCCCCC | 46.58 | 27626673 | |
| 812 | Phosphorylation | SIRREFASPSASSSS HHHHHHCCCCCCCCC | 25.39 | 29892262 | |
| 827 | Phosphorylation | CPSPGDRSASPPERR CCCCCCCCCCCHHHH | 37.53 | 29892262 | |
| 829 | Phosphorylation | SPGDRSASPPERRHM CCCCCCCCCHHHHHH | 42.08 | 29892262 | |
| 1032 | Phosphorylation | TSSHRTASTSPSSSS CCCCCCCCCCCCCCC | 28.89 | 22817900 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of HLES_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of HLES_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of HLES_DROME !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-720; SER-723; SER-746AND SER-753, AND MASS SPECTROMETRY. | |
