VEIN_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VEIN_DROME
• UniProt AC: Q94918
• Protein Name: Protein vein
• Gene Name: vn
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 623
• Subcellular Localization: Secreted.
• Protein Description: Ligand for the EGF receptor. Seems to play a role in the global proliferation of wing disc cells and the larval patterning. Shows a strong synergistic genetic interaction with spi, suggesting a molecular interdependence. Required for the development of interveins cells..
• Protein Sequence: MYAQHLRKWSLKTKKQLMPLILLIISYMLLLNTCVLSSSATTQQQQQQQQQQQHLPRLWEGSAEESSYYIPLSSDNGSGSSESSAESGSSSSRSSSNNIDNNILSRLLSLNSNSLSSRSNVKLKPATVFDAGSSTPAQQEQHVAAVPEQQQQQQQQQQSMQKVPNTLINSQIYNLLYNGMPSEAASSKMRRHIQPSQLPHQPESRAQLPSNYSSRPAVRSYLIESYEMPESMLEDRSPEQAARSRRDGSNTNGSRQQQRTGHRQQLQQDKRDHRRQRQDQQKEQRQQQQQRQHKSGNKHQQQQQQRRKHQRKHQRYNRYCSARDPAQLAFAAPTVFQGVFKSMSADRRVNFSATMKVEKVYKQQHDLQLPTLVRLQFALSNSSGECDIYRERLMPRGMLRSGNDLQQASDISYMMFVQQTNPGNFTILGQPMRVTHLVVEAVETAVSENYTQNAEVTKIFSKPSKAIIKHGKKLRIVCEVSGQPPPKVTWFKDEKSINRKRNIYQFKHHKRRSELIVRSFNSSSDAGRYECRAKNKASKAIAKRRIMIKASPVHFPTDRSASGIPCNFDYCFHNGTCRMIPDINEVYCRCPTEYFGNRCENKWPDSRYFVAIYGQIHTLNNDY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
76	N-linked_Glycosylation	YIPLSSDNGSGSSES EEECCCCCCCCCCCC	48.77	-
211	N-linked_Glycosylation	SRAQLPSNYSSRPAV HHCCCCCCCCCCHHH	38.47	-
249	Phosphorylation	ARSRRDGSNTNGSRQ HHHCCCCCCCCCCHH	44.78	22817900
252	N-linked_Glycosylation	RRDGSNTNGSRQQQR CCCCCCCCCCHHHHH	51.17	-
350	N-linked_Glycosylation	MSADRRVNFSATMKV CCCCCCEECEEEECC	24.28	-
381	N-linked_Glycosylation	RLQFALSNSSGECDI EHHHHHCCCCCCCCH	40.83	-
424	N-linked_Glycosylation	VQQTNPGNFTILGQP EEECCCCCEEECCEE	31.95	-
449	N-linked_Glycosylation	VETAVSENYTQNAEV HHHHHHCCCCCCCEE	37.33	-
521	N-linked_Glycosylation	ELIVRSFNSSSDAGR CEEEECCCCCCCCCC	42.08	-
574	N-linked_Glycosylation	NFDYCFHNGTCRMIP CCCEEECCCEEEECC	27.50	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VEIN_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VEIN_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VEIN_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GRK_DROME	grk	genetic	25336739
BUN1_DROME	bun	genetic	26323255
BUN2_DROME	bun	genetic	26323255
SPITZ_DROME	spi	genetic	10349622
SPITZ_DROME	spi	genetic	11709188
SPITZ_DROME	spi	genetic	25336739
APTE_DROME	ap	genetic	11880346
EGFR_DROME	Egfr	genetic	1980740
EGFR_DROME	Egfr	genetic	10349622
EGFR_DROME	Egfr	genetic	16815386
EGFR_DROME	Egfr	genetic	8824589
SRF_DROME	bs	genetic	9550715
EMC_DROME	emc	genetic	10072780
RHOM_DROME	rho	genetic	11880346
RHOM_DROME	rho	genetic	25336739
BRM_DROME	brm	genetic	15944353
GIL_DROME	aos	genetic	10588875
GIL_DROME	aos	genetic	15238521
PSB1_DROME	Prosbeta6	genetic	15238521
NRBP_DROME	Madm	genetic	26323255
UBX_DROME	Ubx	genetic	16815386
SULF1_DROME	Sulf1	genetic	22595244
ERKA_DROME	rl	genetic	8824589
IHOG_DROME	ihog	physical	23827685

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.