SULF1_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SULF1_DROME
• UniProt AC: Q9VEX0
• Protein Name: Extracellular sulfatase SULF-1 homolog
• Gene Name: Sulf1
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1114
• Subcellular Localization: Endoplasmic reticulum. Golgi apparatus, Golgi stack. Cell surface. Also localized on the cell surface..
• Protein Sequence: MMRHSSLRLIIGGLILLLFVLNVFSKEQGSHSHKRSHSAKRFSRDSNSARERRPNIILILTDDQDVELGSLNFMPRTLRLLRDGGAEFRHAYTTTPMCCPARSSLLTGMYVHNHMVFTNNDNCSSPQWQATHETRSYATYLSNAGYRTGYFGKYLNKYNGSYIPPGWREWGGLIMNSKYYNYSINLNGQKIKHGFDYAKDYYPDLIANDSIAFLRSSKQQNQRKPVLLTMSFPAPHGPEDSAPQYSHLFFNVTTHHTPSYDHAPNPDKQWILRVTEPMQPVHKRFTNLLMTKRLQTLQSVDVAVERVYNELKELGELDNTYIVYTSDHGYHLGQFGLIKGKSFPFEFDVRVPFLIRGPGIQASKVVNEIVLNVDLAPTFLDMGGVPTPQHMDGRSILPLLLSRNRAVRDNWPDSFLIESSGRRETAEQIAESRARLQIERRNMKLANSSLLEDFLEGAGESTTIVSSSSTAATLMSSTAQQPEDGEEEVETDNEEDDVDGDGAMDSSAAALEEDDLDDAAFEEGDEELDQEFQQNNDLPLAPYITKMMRLNSECSDPALLKNCLPGQKWKCVNEEGRWRKHKCKFHLQLEHQLAAMPRKQYQRNCACFTPDGVVYTKIRAPSAGLHRVNKRTHNGPGRRRNKREVFHTELPDEMEELLDLHQVVDQLVDHTHRSKRDLPASSNETIAQVIQQIQSTLEILELKFNEHELHASNSSGNSYERGEKYTKSGGHRCFVDATTAKVNCSNVIYDDEKTWRTSRTQIDMLIKLLKDKIGKLKEMKKQLRESNKQALAAGRRNDNRRRNDQSVLDSGAGPEFNMSYFTEISSTPRSNVVGQTEVFQGYGSASAFDSLEQTQSHRFTPRAECYCEPDVGENHADSKEMAREARRKLKEERQRKKERKRIKKARLEKECLSEKMNCFSHDNQHWRTAPLWNDSPFCFCMNANNNTYSCLRTINGTHNFLYCEFTTGLITFYNLTIDRFETINRAAGLTPGERSHMHDALDQLKSCRGRSCSIRRHQNHLEGGSSAPLLPINQVHRNNKRKHSPLAGAVGNYAFVGPRLDMEALPPIKRRKLSKYNRLTGSQQSHMKRRPWKQTPLQQSPRFLRTHSVTPAQA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
98	3-oxoalanine (Cys)	AYTTTPMCCPARSSL EEECCCCCCCCCHHH	2.37	-
98	Oxidation	AYTTTPMCCPARSSL EEECCCCCCCCCHHH	2.37	-
122	N-linked_Glycosylation	MVFTNNDNCSSPQWQ EEEECCCCCCCCCHH	29.69	-
159	N-linked_Glycosylation	GKYLNKYNGSYIPPG HHHHHHCCCCCCCCC	34.25	-
181	N-linked_Glycosylation	IMNSKYYNYSINLNG EEECCEEEEEEECCC	22.45	-
208	N-linked_Glycosylation	YYPDLIANDSIAFLR HCCHHHHCCHHHHHH	36.25	-
251	N-linked_Glycosylation	QYSHLFFNVTTHHTP CCEEEEEEEECCCCC	23.92	-
387	Phosphorylation	LDMGGVPTPQHMDGR CCCCCCCCCCCCCCC	32.92	22817900
447	N-linked_Glycosylation	RRNMKLANSSLLEDF HHCHHHCCCHHHHHH	42.44	-
683	N-linked_Glycosylation	RDLPASSNETIAQVI CCCCCCCHHHHHHHH	48.19	-
713	N-linked_Glycosylation	EHELHASNSSGNSYE CEEEEECCCCCCCCC	40.76	-
743	N-linked_Glycosylation	DATTAKVNCSNVIYD ECCCCEEECCCCEEC	23.85	17893096
817	N-linked_Glycosylation	SGAGPEFNMSYFTEI CCCCCCCCHHHEEEC	19.48	-
945	N-linked_Glycosylation	CFCMNANNNTYSCLR EEEEECCCCEEEEEE	39.55	-
955	N-linked_Glycosylation	YSCLRTINGTHNFLY EEEEEECCCCCCEEE	49.01	-
974	N-linked_Glycosylation	TGLITFYNLTIDRFE CCEEEEEEEEECCHH	26.90	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SULF1_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SULF1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SULF1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DALY_DROME	dally	genetic	20637191
DALY_DROME	dally	genetic	21305649

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Identification of N-glycosylated proteins from the central nervoussystem of Drosophila melanogaster.";
Koles K., Lim J.-M., Aoki K., Porterfield M., Tiemeyer M., Wells L.,Panin V.;
Glycobiology 17:1388-1403(2007).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-743, AND MASSSPECTROMETRY.
PubMed: 17893096