DALY_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DALY_DROME
• UniProt AC: Q24114
• Protein Name: Division abnormally delayed protein
• Gene Name: dally
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 626
• Subcellular Localization: Cell membrane ; Lipid-anchor, GPI-anchor ; Extracellular side .
• Protein Description: Cell surface proteoglycan that bears heparan sulfate. Required for cell division patterning during post-embryonic development of the nervous system..
• Protein Sequence: MAARSVRLAQLLLFTLLCGFVGLSAAKHLDLDGIHHHQHHLHSATTHHRRRLQRDSRAKDAVGGSTHQCDAVKSYFESIDIKSSGTYSEKGAICGGNCCNNATELELRDKAAGMFEQLLHHHTSSLRGVLETNAKQFQSHVLELAQISENMTHSLFSKVYTRMVPSSRMMIHQLYTEIMNHLIYTSNYTNSNGQLGRRGIGSVQSNLEEAVRHFFVQLFPVAYHQMVHLSKNNLGDLHEDYVNCLQHNFDEMHPFGDIPQQVQSNLGKSVHMSNVFMNALLQAAEVLSEADALYGEQLTDTCKLHLLKMHYCPNCNGHHSSSRSETKLCYGYCKNVMRGCSAEYAGLLDSPWSGVVDSLNNLVTTHILSDTGIINVIKHLQTYFSEAIMAAMHNGPELEKKVKKTCGTPSLTPYSSGEPDARPPPHKNNVKWATDPDPGMVLFLSTIDKSKEFYTTIVDNFCDEQQHSRDDHSCWSGDRFGDYTQLLINPGTDSQRYNPEVPFNAKAQTGKLNELVDKLFKIRKSIGAAAPSNSIQATHDIQNDMGEGSGGGEGQIGDDEEEYGGAHGSGDGSGDGPHTPIEESEGTTTNEVESRDSGKTSGSNPLEGTATWMLLTLVTMLFSSCS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
97	N-linked_Glycosylation	KGAICGGNCCNNATE CCCCCCCCCCCCCCH	16.67	19349973
101	N-linked_Glycosylation	CGGNCCNNATELELR CCCCCCCCCCHHHHH	34.03	19349973
150	N-linked_Glycosylation	ELAQISENMTHSLFS HHHHHCCHHCHHHHH	33.58	-
187	N-linked_Glycosylation	NHLIYTSNYTNSNGQ HHHHHHCCCCCCCCC	39.59	-
549	O-linked_Glycosylation	QNDMGEGSGGGEGQI CCCCCCCCCCCCCCC	29.93	-
569	O-linked_Glycosylation	EYGGAHGSGDGSGDG CCCCCCCCCCCCCCC	24.68	-
573	O-linked_Glycosylation	AHGSGDGSGDGPHTP CCCCCCCCCCCCCCC	38.15	-
601	O-linked_Glycosylation	SRDSGKTSGSNPLEG ECCCCCCCCCCCCHH	43.65	-
602	GPI-anchor	RDSGKTSGSNPLEGT CCCCCCCCCCCCHHH	36.35	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DALY_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DALY_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DALY_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
POXM_DROME	Poxm	physical	14605208
SETB1_DROME	egg	genetic	22216012
ARM_DROME	arm	genetic	10421372
DECA_DROME	dpp	genetic	9374407
MAD_DROME	Mad	genetic	17055473
WNTG_DROME	wg	genetic	10421371
WNTG_DROME	wg	genetic	10421372
WNTG_DROME	wg	genetic	11437449
PTC_DROME	ptc	genetic	15963974
NDST_DROME	sfl	genetic	10421372
CCNA_DROME	CycA	genetic	11801730
S35B2_DROME	sll	genetic	12853478
HH_DROME	hh	physical	17609110
APLP_DROME	Rfabg	physical	17609110

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.";
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,Schiess R., Aebersold R., Watts J.D.;
Nat. Biotechnol. 27:378-386(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-97 AND ASN-101, AND MASSSPECTROMETRY.
PubMed: 19349973