PTC_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PTC_DROME
• UniProt AC: P18502
• Protein Name: Protein patched
• Gene Name: ptc
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1286
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Description: Segmentation polarity protein. Acts as a receptor for the hedgehog protein (HH). Associates with the smoothened protein (SMO) to transduce the hedgehog signal leading to the activation of wingless, decapentaplegic and patched itself. Participates in cell interactions that establish pattern within the segment and the imaginal disks during development. In the absence of HH, represses the constitutive signaling activity of smo through fused (FU)..
• Protein Sequence: MDRDSLPRVPDTHGDVVDEKLFSDLYIRTSWVDAQVALDQIDKGKARGSRTAIYLRSVFQSHLETLGSSVQKHAGKVLFVAILVLSTFCVGLKSAQIHSKVHQLWIQEGGRLEAELAYTQKTIGEDESATHQLLIQTTHDPNASVLHPQALLAHLEVLVKATAVKVHLYDTEWGLRDMCNMPSTPSFEGIYYIEQILRHLIPCSIITPLDCFWEGSQLLGPESAVVIPGLNQRLLWTTLNPASVMQYMKQKMSEEKISFDFETVEQYMKRAAIGSGYMEKPCLNPLNPNCPDTAPNKNSTQPPDVGAILSGGCYGYAAKHMHWPEELIVGGAKRNRSGHLRKAQALQSVVQLMTEKEMYDQWQDNYKVHHLGWTQEKAAEVLNAWQRNFSREVEQLLRKQSRIATNYDIYVFSSAALDDILAKFSHPSALSIVIGVAVTVLYAFCTLLRWRDPVRGQSSVGVAGVLLMCFSTAAGLGLSALLGIVFNAASTQVVPFLALGLGVDHIFMLTAAYAESNRREQTKLILKKVGPSILFSACSTAGSFFAAAFIPVPALKVFCLQAAIVMCSNLAAALLVFPAMISLDLRRRTAGRADIFCCCFPVWKEQPKVAPPVLPLNNNNGRGARHPKSCNNNRVPLPAQNPLLEQRADIPGSSHSLASFSLATFAFQHYTPFLMRSWVKFLTVMGFLAALISSLYASTRLQDGLDIIDLVPKDSNEHKFLDAQTRLFGFYSMYAVTQGNFEYPTQQQLLRDYHDSFVRVPHVIKNDNGGLPDFWLLLFSEWLGNLQKIFDEEYRDGRLTKECWFPNASSDAILAYKLIVQTGHVDNPVDKELVLTNRLVNSDGIINQRAFYNYLSAWATNDVFAYGASQGKLYPEPRQYFHQPNEYDLKIPKSLPLVYAQMPFYLHGLTDTSQIKTLIGHIRDLSVKYEGFGLPNYPSGIPFIFWEQYMTLRSSLAMILACVLLAALVLVSLLLLSVWAAVLVILSVLASLAQIFGAMTLLGIKLSAIPAVILILSVGMMLCFNVLISLGFMTSVGNRQRRVQLSMQMSLGPLVHGMLTSGVAVFMLSTSPFEFVIRHFCWLLLVVLCVGACNSLLVFPILLSMVGPEAELVPLEHPDRISTPSPLPVRSSKRSGKSYVVQGSRSSRGSCQKSHHHHHKDLNDPSLTTITEEPQSWKSSNSSIQMPNDWTYQPREQRPASYAAPPPAYHKAAAQQHHQHQGPPTTPPPPFPTAYPPELQSIVVQPEVTVETTHSDSNTTKVTATANIKVELAMPGRAVRSYNFTS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
142	N-linked_Glycosylation	IQTTHDPNASVLHPQ EEECCCCCCCCCCHH	51.40	-
298	N-linked_Glycosylation	PDTAPNKNSTQPPDV CCCCCCCCCCCCCCC	57.86	-
335	N-linked_Glycosylation	IVGGAKRNRSGHLRK HCCCCCCCCCCHHHH	41.59	-
388	N-linked_Glycosylation	VLNAWQRNFSREVEQ HHHHHHHHHHHHHHH	24.93	-
536	Phosphorylation	VGPSILFSACSTAGS HCHHHHHHHHCCCCC	25.56	22817900
807	N-linked_Glycosylation	TKECWFPNASSDAIL EECCCCCCCCCHHHH	42.87	-
1122	Phosphorylation	LEHPDRISTPSPLPV CCCCCCCCCCCCCCC	34.85	19429919
1123	Phosphorylation	EHPDRISTPSPLPVR CCCCCCCCCCCCCCC	25.97	19429919
1125	Phosphorylation	PDRISTPSPLPVRSS CCCCCCCCCCCCCCC	38.87	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PTC_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PTC_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PTC_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RAD51_DROME	spn-A	physical	15575970
CEG1A_DROME	CenG1A	physical	15575970
LIP3_DROME	Lip3	physical	15575970
NPL4_DROME	Npl4	physical	15575970
ECR_DROME	EcR	physical	15575970
TID_DROME	l(2)tid	physical	12783860
MOEH_DROME	Moe	physical	15710747
ZN330_DROME	Noa36	physical	15710747
ABRU_DROME	ab	physical	15710747
BTKL_DROME	Btk29A	physical	15710747
DCLK_DROME	CG17528	physical	15710747
FLNA_DROME	cher	physical	15710747
HIW_DROME	hiw	physical	15710747
PPN_DROME	Ppn	physical	15710747
FRIZ2_DROME	fz2	physical	15710747
MLP2_DROME	Mlp84B	physical	15710747
HRD1_DROME	sip3	physical	15710747
GALT6_DROME	pgant6	physical	15710747
CYHR1_DROME	CG32486	physical	15710747
NU160_DROME	Nup160	physical	15710747
TONSL_DROME	CG7457	physical	15710747
CHD1_DROME	Chd1	physical	15710747
LACH_DROME	Lac	physical	15710747
LAMA_DROME	LanA	physical	15710747
ITBX_DROME	mys	physical	15710747
NCD_DROME	ncd	physical	15710747
NEDD4_DROME	Nedd4	physical	15710747
POF_DROME	Pof	physical	15710747
PTC_DROME	ptc	physical	15710747
DGK2_DROME	rdgA	physical	15710747
RG190_DROME	RhoGAPp190	physical	15710747
RL22_DROME	RpL22	physical	15710747
SAS_DROME	sas	physical	15710747
ITA3_DROME	scb	physical	15710747
KCNAB_DROME	Shab	physical	15710747
SINA_DROME	sina	physical	15710747
SNAI_DROME	sna	physical	15710747
TF2B_DROME	TfIIB	physical	15710747
FUSED_DROME	fu	genetic	9874371
FUSED_DROME	fu	genetic	11820817
FUSED_DROME	fu	genetic	8861096
SMO_DROME	smo	genetic	11934850
SMO_DROME	smo	genetic	9598354
SMO_DROME	smo	genetic	11112325
SMO_DROME	smo	genetic	15754211
SMO_DROME	smo	genetic	19635474
DECA_DROME	dpp	genetic	8306973
DECA_DROME	dpp	genetic	9102309
DECA_DROME	dpp	genetic	11112325
HMEN_DROME	en	genetic	26575288
YAP1_DROME	yki	genetic	22705500
VEIN_DROME	vn	genetic	10588875
HH_DROME	hh	genetic	8575316
HH_DROME	hh	genetic	11112325
CI_DROME	ci	genetic	8575316
CI_DROME	ci	genetic	8861096
CI_DROME	ci	genetic	11171398
HHAT_DROME	rasp	genetic	16459296
COLL_DROME	kn	genetic	9383063
SMO_DROME	smo	physical	17284519
SUDX_DROME	Su(dx)	physical	24302888
IHOG_DROME	ihog	physical	20501592
PTC_DROME	ptc	physical	10983992
PTC_DROME	ptc	physical	16980583
PTC_DROME	ptc	physical	17284519
SMUF1_DROME	lack	physical	24302888
SXL_DROME	Sxl	physical	17284519
NEDD4_DROME	Nedd4	physical	16980583
NEDD4_DROME	Nedd4	physical	24302888
HH_DROME	hh	physical	12783860
HH_DROME	hh	physical	16980583
HH_DROME	hh	physical	20048000
APLP_DROME	Rfabg	physical	18198278

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.