dbPTM

LACH_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	LACH_DROME
UniProt AC	Q24372
Protein Name	Lachesin
Gene Name	Lac
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	359
Subcellular Localization	Cell membrane Lipid-anchor, GPI-anchor Extracellular side . Located at the extracellular face of the membrane and becomes associated with septate junctions.
Protein Description	Required for normal tracheal development and maintenance of the trans-epithelial diffusion barrier. Functions as a homophilic cell-adhesion molecule. May play a role in early neuronal differentiation and axon outgrowth..
Protein Sequence	MWRPSISNCVWSTLLLAIFVQQTLAQRTPTISYITQEQIKDIGGTVEFDCSVQYAKEYNVLFLKTDSDPVFLSTGSTLVIKDSRFSLRYDPNSSTYKLQIKDIQETDAGTYTCQVVISTVHKVSAEVKLSVRRPPVISDNSTQSVVASEGSEVQMECYASGYPTPTITWRRENNAILPTDSATYVGNTLRIKSVKKEDRGTYYCVADNGVSKGDRRNINVEVEFAPVITVPRPRLGQALQYDMDLECHIEAYPPPAIVWTKDDIQLANNQHYSISHFATADEYTDSTLRVITVEKRQYGDYVCKATNRFGEAEARVNLFETIIPVCPPACGQAYIAGAEDVSATSFALVGILAALLFAR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
92	N-linked_Glycosylation	FSLRYDPNSSTYKLQ EEEEECCCCCEEEEE	45.77	-
130	Phosphorylation	VSAEVKLSVRRPPVI EEEEEEEEECCCCCC	14.09	22817900
140	N-linked_Glycosylation	RPPVISDNSTQSVVA CCCCCCCCCCCEEEE	39.92	-
336	GPI-anchor	ACGQAYIAGAEDVSA CCCCHHHCCCCCCCH	9.85	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of LACH_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of LACH_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of LACH_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
RL7_DROME	RpL7	physical	14605208
LACH_DROME	Lac	physical	23827685

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of LACH_DROME

Related Literatures of Post-Translational Modification