| UniProt ID | RG190_DROME | |
|---|---|---|
| UniProt AC | Q9VX32 | |
| Protein Name | Rho GTPase-activating protein 190 | |
| Gene Name | RhoGAPp190 | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 1561 | |
| Subcellular Localization | ||
| Protein Description | GTPase-activating protein (GAP) for RhoA/Rho1 that plays an essential role in the stability of dorsal branches of mushroom body (MB) neurons. The MB neurons are the center for olfactory learning and memory. Acts by converting RhoA/Rho1 to an inactive GDP-bound state, leading to repress the RhoA/Rho1-Drok-MRLC signaling pathway thereby maintaining axon branch stability.. | |
| Protein Sequence | MRQFNISVIGLSGTEKDRGQVGVGKSCLCNRFMRPMADDYFIDHISVLSQSDFSGRIVNNDHFLYWGDVRKTTEEGVEYQFNIIEQTEFMDDSTFQAFKVGKMDPYSKRCTATKVFSAEKLMYICKNQLGIEKEYEQKVMPDGRLSIDGFVVVFDVSPVPNRSVEKQVEFVQNVIATILKNKKPLVLVTTKNDDAYELYVREAEKISQRKDYKSTVQLIETSAHESINIDLAFLLLAQMIDKVKNRVKIISYQESAKSRKELLDTRSEAVTRLIRNQITDYHVLWSQGSKMLSQYREWNEFLNIFGHEAGQKLFRRHMKKLRDDHLNKKLHQYLDKFALALEYLLPDIGALNISDDDAWECARNYLQNHIEFEQYFFECPQASWTELVDMDEAEDEARIPFDVLETSEAETVFRNYLNSVQQDKKKIGWKQQFKMLLEESGFVTPGKQLSEVRVLFMGRECFEALSEHDCQQIYDIHQDDIIEKSKQNFVELLLEHAQYFLQFKNVDNITQEDVRQITDVIQEDSRYKMLDRLDQERRLMLVQHLRFIHCPIRDHCPFFYNCVDSLIEEVLSDKSASNHKTPSGGGWKSSGSGSDRTLNLLIVGSEHLASDLLNDIRICTGSKGEYIYENQTYYLNYRIANGDMEAFKAIDVYSSGLICVYSNQQSFETLKDNLERTLLCNLELEDKFENLPIVLVYQPQDLKENEVEYLRNEGMRLSEMLHCDFIDHTQNHQKYVYDILNIVILSLKLTEMKSYEPYPSNHTDLRILCCIFCGDQYDIENIVQPLVEESTLVKANEHSIIVDVFIGDAKRRVEFILSSYHGTSQYRDELIHGYIYFYSTKRRSSLANLSILAAQNANIPLQIIAVTESGGVNAFFNSDICQFLITEGNAVADRFKGSFMTFSADQYVKFAFYNPFLKTAWDNKYEVENLHVEESITLDSGEGTLENSVNQMPRPPPRHESYMLSNTLGTDGSGSENYEMAPTRSLNSLNEERDISLDEIYDDNEKPKHLHQKWLEDKSDGRRNMNKNLIWNNFSGSTHAYTTGRRHIDSNLNKIRPKGPSQTLKVGEAPSRNCPAMSSSTFTLPTQQPGKLNMKNFQLVSDAVAKMNFTGSGSGSGSGSGSGSTGLGLGLGSGSGCMGDSFLEPVDKDGKRYDHAQLDGEDEDSEELAEYEQIYENEDCTESDSCASSTERRVRQQNAYYKASKKPVAAKKQKKKKVAIPVQTPRVPPFGSYVSPPEIPLHYQRMAVGGSGPEKPEPCVPEFMKSDKSPEYSMVPELAGAGIFGAENLPEYNMNQAKCLKDFEKLEKRRIKEETARQRKLQEKEKEQEKKLKRKLKQNAKGLVESAEAQFGKLMITSEQGEIPIFLNKCVEFIEKEGLDSEGIYRVPGSRAHVDMLFQRFEEDTNTEIDALDIPVNAVATALKDFFSKRLPPLFSKDIIKELEEIAGSRGVGNSKLNVEVKTDRSCRLIALKSLLQKLPPINFAILKYIFQHFVHVSDNSKLNSMDSKNLAICWWPTLIPIDFTDMGHFEQLRPYLEDIVQTMIDQFPYLFCGKDAFVMV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 633 | Phosphorylation | YIYENQTYYLNYRIA EEEECCEEEEEEEEC | 9.01 | 22668510 | |
| 634 | Phosphorylation | IYENQTYYLNYRIAN EEECCEEEEEEEECC | 7.58 | 22668510 | |
| 973 | Phosphorylation | NTLGTDGSGSENYEM CCCCCCCCCCCCCCC | 41.79 | 22817900 | |
| 975 | Phosphorylation | LGTDGSGSENYEMAP CCCCCCCCCCCCCCC | 25.11 | 22817900 | |
| 985 | Phosphorylation | YEMAPTRSLNSLNEE CCCCCCCCCCCCCCC | 34.09 | 19429919 | |
| 988 | Phosphorylation | APTRSLNSLNEERDI CCCCCCCCCCCCCCC | 37.55 | 19429919 | |
| 996 | Phosphorylation | LNEERDISLDEIYDD CCCCCCCCHHHHCCC | 33.77 | 19429919 | |
| 1001 | Phosphorylation | DISLDEIYDDNEKPK CCCHHHHCCCCCCCC | 18.39 | 19429919 | |
| 1078 | Phosphorylation | SRNCPAMSSSTFTLP CCCCCCCCCCCEECC | 24.20 | 21082442 | |
| 1080 | Phosphorylation | NCPAMSSSTFTLPTQ CCCCCCCCCEECCCC | 21.89 | 21082442 | |
| 1200 | Phosphorylation | RVRQQNAYYKASKKP HHHHHHHHHHHCCCC | 17.04 | 18281928 | |
| 1224 | Phosphorylation | KVAIPVQTPRVPPFG CEECCCCCCCCCCCC | 17.19 | 21082442 | |
| 1243 | Phosphorylation | PPEIPLHYQRMAVGG CCCCCCEEEECCCCC | 12.90 | 18281928 | |
| 1269 (in isoform 2) | Phosphorylation | - | 28.14 | 27794539 | |
| 1272 (in isoform 2) | Phosphorylation | - | 12.88 | 27794539 | |
| 1346 | Phosphorylation | NAKGLVESAEAQFGK HHHHHHHHHHHHHCC | 24.75 | 27794539 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RG190_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RG190_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RG190_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| SQH_DROME | sqh | genetic | 11672527 | |
| SEM1A_DROME | Sema-1a | genetic | 23177958 | |
| RHO1_DROME | Rho1 | genetic | 11672527 | |
| ITBX_DROME | mys | genetic | 11672527 | |
| SRC64_DROME | Src64B | genetic | 11672527 | |
| SEM1A_DROME | Sema-1a | physical | 23177958 | |
| PLXB_DROME | PlexB | physical | 23177958 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-973; SER-975; SER-985;SER-988 AND SER-996, AND MASS SPECTROMETRY. | |
