| UniProt ID | ITBX_DROME | |
|---|---|---|
| UniProt AC | P11584 | |
| Protein Name | Integrin beta-PS | |
| Gene Name | mys | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 846 | |
| Subcellular Localization |
Apical cell membrane Single-pass type I membrane protein . Lateral cell membrane Single-pass type I membrane protein . Basal cell membrane Single-pass type I membrane protein . In ovary, localizes to the apical, lateral and basal membranes of f |
|
| Protein Description | Integrin alpha-PS1/beta-PS is a receptor for laminin. [PubMed: 7972082 Integrin alpha-PS2/beta-PS is a receptor for Tig, wb and Ten-m] | |
| Protein Sequence | MILERNRRCQLALLMIAILAAIAGQTDAQKAAKLTAVSTCASKEKCHTCIQTEGCAWCMQPDFKGQSRCYQNTSSLCPEEFAYSPITVEQILVNNKLTNQYKAELAAGGGGSAMSGSSSSSYSSSSSSSSFYSQSSSGSSSASGYEEYSAGEIVQIQPQSMRLALRVNEKHNIKISYSQAEGYPVDLYYLMDLSKSMEDDKAKLSTLGDKLSETMKRITNNFHLGFGSFVDKVLMPYVSTIPKKLEHPCENCKAPYGYQNHMPLNNNTESFSNEVKNATVSGNLDAPEGGFDAIMQAIACRSQIGWREQARRLLVFSTDAGFHYAGDGKLGGVIAPNDGECHLSPKGEYTHSTLQDYPSISQINQKVKDNAINIIFAVTASQLSVYEKLVEHIQGSSAAKLDNDSSNVVELVKEEYRKISSSVEMKDNATGDVKITYFSSCLSNGPEVQTSKCDNLKEGQQVSFTAQIQLLKCPEDPRDWTQTIHISPVGINEVMQIQLTMLCSCPCENPGSIGYQVQANSCSGHGTSMCGICNCDDSYFGNKCECSATDLTSKFANDTSCRADSTSTTDCSGRGHCVCGACECHKRPNPIEIISGKHCECDNFSCERNRNQLCSGPDHGTCECGRCKCKPGWTGSNCGCQESNDTCMPPGGGEICSGHGTCECGVCKCTVNDQGRFSGRHCEKCPTCSGRCQELKDCVQCQMYKTGELKNGDDCARNCTQFVPVGVEKVEIDETKDEQMCKFFDEDDCKFMFKYSEQGELHVYAQENKECPAKVFMLGIVMGVIAAIVLVGLAILLLWKLLTTIHDRREFARFEKERMNAKWDTGENPIYKQATSTFKNPMYAGK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 72 | N-linked_Glycosylation | GQSRCYQNTSSLCPE CCCCCCCCCCCCCCH | 18.56 | - | |
| 266 | N-linked_Glycosylation | QNHMPLNNNTESFSN CCCCCCCCCCHHCCH | 65.56 | 19349973 | |
| 277 | N-linked_Glycosylation | SFSNEVKNATVSGNL HCCHHHHHCEEECCC | 46.12 | - | |
| 403 | N-linked_Glycosylation | SSAAKLDNDSSNVVE CCCCCCCCCCCCHHH | 62.59 | 17893096 | |
| 428 | N-linked_Glycosylation | SSVEMKDNATGDVKI CCEEECCCCCCCEEE | 33.61 | - | |
| 557 | N-linked_Glycosylation | DLTSKFANDTSCRAD CCHHHHCCCCCCCCC | 57.11 | 17893096 | |
| 603 | N-linked_Glycosylation | GKHCECDNFSCERNR CCCCCCCCCCCCCCC | 42.25 | - | |
| 644 | N-linked_Glycosylation | NCGCQESNDTCMPPG CCCCCCCCCCCCCCC | 48.10 | - | |
| 718 | N-linked_Glycosylation | NGDDCARNCTQFVPV CCHHHCCCCCEEEEC | 18.05 | 17893096 | |
| 831 | Phosphorylation | DTGENPIYKQATSTF CCCCCCHHHCHHHCC | 9.78 | 19429919 | |
| 843 | Phosphorylation | STFKNPMYAGK---- HCCCCCCCCCC---- | 17.29 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ITBX_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ITBX_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ITBX_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| ITA3_DROME | scb | physical | 9409675 | |
| UGDH_DROME | sgl | genetic | 9136017 | |
| FAS2_DROME | Fas2 | genetic | 12091308 | |
| SWS_DROME | sws | genetic | 12696671 | |
| ITA1_DROME | mew | genetic | 22243747 | |
| ITA2_DROME | if | genetic | 10532829 | |
| ITBN_DROME | Itgbetanu | genetic | 15469969 | |
| ECR_DROME | EcR | genetic | 10753511 | |
| MAM_DROME | mam | genetic | 9136017 | |
| SLIT_DROME | sli | genetic | 12040052 | |
| SRF_DROME | bs | genetic | 1339662 | |
| SRF_DROME | bs | genetic | 9136017 | |
| SRF_DROME | bs | genetic | 9755209 | |
| VEIN_DROME | vn | genetic | 10821759 | |
| CANB_DROME | CalpB | genetic | 22827336 | |
| LASP1_DROME | Lasp | genetic | 18655828 | |
| DL_DROME | Dl | genetic | 9136017 | |
| KCC2A_DROME | CaMKII | genetic | 12091308 | |
| ITA1_DROME | mew | physical | 7972082 | |
| ITA2_DROME | if | physical | 7972082 | |
| ZASP_DROME | Zasp52 | physical | 22992465 | |
| PLXB_DROME | PlexB | physical | 26853303 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| N-linked Glycosylation | |
| Reference | PubMed |
| "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."; Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,Schiess R., Aebersold R., Watts J.D.; Nat. Biotechnol. 27:378-386(2009). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-266; ASN-403; ASN-557 ANDASN-718, AND MASS SPECTROMETRY. | |
| "Identification of N-glycosylated proteins from the central nervoussystem of Drosophila melanogaster."; Koles K., Lim J.-M., Aoki K., Porterfield M., Tiemeyer M., Wells L.,Panin V.; Glycobiology 17:1388-1403(2007). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-403; ASN-557 AND ASN-718,AND MASS SPECTROMETRY. | |
