CANB_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CANB_DROME
• UniProt AC: Q9VT65
• Protein Name: Calpain-B
• Gene Name: CalpB {ECO:0000312|EMBL:AAF50189.2, ECO:0000312|FlyBase:FBgn0025866}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 925
• Subcellular Localization: Cytoplasm . Membrane . Translocates to intracellular membranes when calcium levels are increased.
• Protein Description: Calcium-regulated non-lysosomal thiol-protease..
• Protein Sequence: MYGIDNYPKNYHASGIGLVNLAALGYSKNEVSGGNEGGGAPKPKAGLYPSLPYPSSESVGGMPYVVKQTSHAQNASYAGPTMGMGMPVPEAPSAPAPYPSATPYPGSGLYPSLPSANVSSLPYPTAPMAPYPTGMPYPTGMPQPNLPYPAAPLAPYPSAMPGLPGMPMPYAPMPTSPAPQHNIGFPALPYPTAPPPESAPTQEEEPSVGVAELSFTSVKVPENQNMFWMGRKATSARQNSVSKGDFQSLRDSCLANGTMFEDPDFPATNASLMYSRRPDRYYEWLRPGDIADDPQFFVEGYSRFDVQQGELGDCWLLAAAANLTQDSTLFFRVIPPDQDFQENYAGIFHFKFWQYGKWVEVVIDDRLPTYNGELIYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGTTCEAMEDFTGGVTEWYDIKEAPPNLFSIMMKAAERGSMMGCSLEPDPHVLEAETPQGLIRGHAYSITKVCLMDISTPNRQGKLPMIRMRNPWGNDAEWSGPWSDSSPEWRFIPEHTKEEIGLNFDRDGEFWMSFQDFLNHFDRVEICNLSPDSLTEDQQHSSRRKWEMSMFEGEWTSGVTAGGCRNFLETFWHNPQYIISLEDPDDEDDDGKCTAIVALMQKNRRSKRNVGIDCLTIGFAIYHLTDRDMQVKPQGLNFFKYRASVARSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETRNNMEENDDEVGFGETDDRIAPSLPPPTPKEEDDPQRIALRRLFDSVAGSDEEVDWQELKRILDHSMRDVMVGSDGFSKDAVRSMVAMLDKDRSGRLGFEEFEALLTDIAKWRAVFKLYDTRRTGSIDGFHLRGALNSAGYHLNNRLLNALAHRYGSREGQIPFDDFLMCAIKVRTFIEMFRERDTDNSDTAFFNLDDWLERTIYS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
240	Phosphorylation	ATSARQNSVSKGDFQ HCHHHCCCCCCHHHH	21.30	27794539
242	Phosphorylation	SARQNSVSKGDFQSL HHHCCCCCCHHHHHH	30.64	27794539
747	Phosphorylation	APSLPPPTPKEEDDP CCCCCCCCCCCCCCH	53.41	22817900
803	Phosphorylation	FSKDAVRSMVAMLDK CCHHHHHHHHHHHCC	15.83	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CANB_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CANB_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CANB_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ITA2_DROME	if	genetic	22827336
ITBX_DROME	mys	genetic	22827336

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.