SRF_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SRF_DROME
• UniProt AC: Q24535
• Protein Name: Serum response factor homolog
• Gene Name: bs
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 449
• Subcellular Localization: Nucleus .
• Protein Description: Required for the formation of intervein tissue of the wing. Acts in a dosage-dependent manner to suppress wing vein formation and promote development of intervein cells. Might play a role in the proper formation and maintenance of the trachea..
• Protein Sequence: MDPTRGDSRYNLNYSMSSIGLSLADPADMYGNPALGAGRPPSGGLLQNMGGVPPMQRPNPAAGAPPAPQCQTLHSPQHASQQQQQQQQQQQQHQQQQQQQQQHPQQQRGLKRSGSDCYEDHHRSSGGLTLQGLDNVASGAVDDSVDNYNPLPNKKSPPANGKKTKGRVKIKMEYIDNKLRRYTTFSKRKTGIMKKAYELSTLTGTQVMLLVASETGHVYTFATRKLQPMITSEAGKQLIQTCLNSPDPPSVGGGDQRMSATGFEETELSYNIADEDSKDDRSPTSSGNESDDSSDVEMPAEAAEVATKLPASKTEVSAPPAASCSAATASSGHKTMPALNYQTDTNSGPSTSTAAGGGGSADSKYVYSAASIANIPQKMLRQLIQSGHLQVHAEEDGNQYVTIPLSSTAANLIKSNKLTASGSGASGSGTPVKNDASADKPLTIKQEFD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
113	Phosphorylation	QQRGLKRSGSDCYED HHHHHHHCCCCCCCC	40.85	21082442
115	Phosphorylation	RGLKRSGSDCYEDHH HHHHHCCCCCCCCCC	26.25	21082442
118	Phosphorylation	KRSGSDCYEDHHRSS HHCCCCCCCCCCCCC	29.40	25749252
156	Phosphorylation	NPLPNKKSPPANGKK CCCCCCCCCCCCCCC	37.41	22817900
440	Acetylation	KNDASADKPLTIKQE CCCCCCCCCCEECCC	41.46	21791702

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SRF_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SRF_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SRF_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MERH_DROME	Mer	genetic	11404331
EMC_DROME	emc	genetic	10072780
RHOM_DROME	rho	genetic	7956840
BRM_DROME	brm	genetic	15013794
OSA_DROME	osa	genetic	19306864
DEI_DROME	tx	genetic	21215259
ITBX_DROME	mys	genetic	7956840
CSW_DROME	csw	genetic	11014820
TIM10_DROME	Tim10	physical	25242320
ETIF1_DROME	CG17737	physical	25242320
KPYK_DROME	PyK	physical	25242320

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-156, AND MASSSPECTROMETRY.
PubMed: 18327897