KPYK_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KPYK_DROME
• UniProt AC: O62619
• Protein Name: Pyruvate kinase
• Gene Name: PyK
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 533
• Protein Sequence: MVNVTIYDEAPQLKPNEVPQNMAAGADTQLEHMCRLQFDSPVPHVRLSGIVCTIGPASSSVEMLEKMMATGMNIARMNFSHGSHEYHAATVANVRQAVKNYSAKLGYEHPVAIALDTKGPEIRTGLIGGSGTAEIELKKGEKIKLTTNKEFLEKGSLEIVYVDYENIVNVVKPGNRVFVDDGLISLIVREVGKDSLTCEVENGGSLGSRKGVNLPGVPVDLPAVSEKDKSDLLFGVEQEVDMIFASFIRNAAALTEIRKVLGEKGKNIKIISKIENQQGMHNLDEIIEAGDGIMVARGDLGIEIPAEKVFLAQKAMIARCNKAGKPVICATQMLESMVKKPRPTRAEISDVANAVLDGADCVMLSGETAKGEYPLECVLTMAKTCKEAEAALWHQNLFNDLVRGAGTIDASHAAAIAAVEAATKAKASAIVVITTSGKSAFQVSKYRPRCPIIAVTRFAQTARQAHLYRGLVPLIYKEPGLGDWLKDVDVRVQFGLQVGKKNGFIKTGDSVVVVTGWKQGSGFTNTIRIVTVE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
40	Phosphorylation	MCRLQFDSPVPHVRL HHHCCCCCCCCCEEE	29.14	19429919
58	Phosphorylation	VCTIGPASSSVEMLE EEEECCCCCHHHHHH	26.69	22817900
59	Phosphorylation	CTIGPASSSVEMLEK EEECCCCCHHHHHHH	40.27	22817900
60	Phosphorylation	TIGPASSSVEMLEKM EECCCCCHHHHHHHH	21.43	22817900
149	Acetylation	KIKLTTNKEFLEKGS EEEEECCHHHHHHCC	47.99	21791702
336	Phosphorylation	CATQMLESMVKKPRP EEHHHHHHHHCCCCC	25.55	22817900
403	Ubiquitination	NLFNDLVRGAGTIDA HHHHHHHHCCCCCCH	36.22	31113955
407	Phosphorylation	DLVRGAGTIDASHAA HHHHCCCCCCHHHHH	18.36	21082442
411	Phosphorylation	GAGTIDASHAAAIAA CCCCCCHHHHHHHHH	15.20	21082442
424	Ubiquitination	AAVEAATKAKASAIV HHHHHHHHCCCCEEE	43.07	31113955
435	Phosphorylation	SAIVVITTSGKSAFQ CEEEEEECCCCCCCC	25.10	27794539
439	Phosphorylation	VITTSGKSAFQVSKY EEECCCCCCCCCCCC	37.53	27794539
521	Phosphorylation	VTGWKQGSGFTNTIR ECEECCCCCCCCEEE	28.39	21082442
526	Phosphorylation	QGSGFTNTIRIVTVE CCCCCCCEEEEEEEC	14.47	27626673

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KPYK_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KPYK_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KPYK_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TCPA_DROME	T-cp1	physical	22036573
TUD_DROME	tud	physical	25600116

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.