TUD_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TUD_DROME
• UniProt AC: P25823
• Protein Name: Maternal protein tudor
• Gene Name: tud
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 2515
• Protein Description: Required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation..
• Protein Sequence: MNGQARIALPSKVDLYITHVDHVGPYLKVYGHVNRDAASLISERIRNLLPTCFAIEPSWSVERQQALLIPGTFCIFKNINGPAPGDVEYRRIRVVSADLEGQSMRAEIDFVDFGYKRTVDSHDLMFPKQPKLLQNIPLHCFQYIVLGICSEWDQTDLAEVRRLVVNQIVKITVEPTQICDQKFASLRWKDFELNEFLVQQKQIGVSVDKQLMMDHCKKLWKDNPQSPVTEYNNNSIHNSKTPMEIAREQLAVRQSLAARLDAQRSVQVTPSRPLNADAPDYTPKHLPLVNVTNVQVQMPGLNNTQKPVFVSTNPYNRANYQPAVPAAQPYVPKANPRSQYTYYNVRMNKPINAMPPPAGPHVPIQHFNQQANNVSLSYVPARFTPPPTPSIAQHQIPIPAFRTTSLTVGLTYDVVISYVENGPYLFWVHLKSSDHDLSTMMGQIERTKLKALAQAPELGTACVARFSEDGHLYRAMVCAVYAQRYRVVYVDYGNSELLSASDLFQIPPELLEIKPFAFRFALAGTKEIEPIDDSMKRIFKKSAIYRNFELTVQAPESVGSMQTCHLNQNGTNMLELLRQLKNSRQSYKKAEQLENDDAVEIRFIDSPSNFYVQKVANIGKFEQLMDEMFSYYNANQRVPDQLILGAPCIVKCDQEWYRAEILRVDDSVIVRHVDFGYEQNVKRHLIGHIAEKHLEMPRQAIKCCLKGFENSELSEDKITDQFEMLAEESNIRRRTFSVRIFRIEPDGLNVVNLLAKNLNVMKKLYKLSMPFEQYLSLEKGQFNANNTRAESVISSELNKSHILNSTSIGETENRLQEQEKEQQQKKVDVRQQQLAVEIPQAVKSVSGSKNSTDWDKRSSTSAGSKDSKRQQQQQIQRIDRHLDFSCETQSTGSYSSGMSSPRKGNRQQNGRTPIQSPRHNEKQEAKKNARFSNSESPRRSRDGQQGNQRSQNAPQGYAQKPQRQKSTLDGNISSKRSSGVGSDIASSSSESVAAAKPEKYVSLDKPYALQEMKTPSKEAASLSWWLSPFQFYIVPKSVSAKYDNIMRDMREFYRQKQHQPLQLKVGSTVVVRQRKDNAILRATVTACNHMMRKYRVFCVDTGSLITVTSEDIWQLEQRFADPPCMAHRCSFHSVVTNYDPLYIVDRMETFVPVNAKVDCEFVSKEKSNQGSNTSSTCSYTVNIFVNGASLRDMLVKAEFLTEVAPEIRVNLLAGQQIRGKFTSIRDMTSFKVQFDYGNNVNFLCTYDDAKFVKSNPNLARRFKEFYEGKSFALNVKNVCENNIVHLRPVMPLFMEDRRSFICPYPVVLSSFQALVVYTAKPYRVYVQPQAIVPSMQTLLDNMYEHYKAKGDSLKKFDVGQICAVRSSDGNWYRARISGKDSNAACFEVFYIDYGNTEEIKRDDIKALDAKFYEHASGFAVEINLPIGRPSNDTKLKARISEILEEKVVTIKSIEVRRSHLIADVILENNQSVIDLLKAEKLVPGKDLDYMRKQMEKGKSRTYEYIETVDLTLDEEEDKGRKETVSKSGSANASPKKKQHNDKDREPKKSKPAEPARTVAPQPVALKTPSPVPAEPAPVPKPATPVPEVVEVPEINPTVREAAAESKQAPAQEDPYKDLDCVVLSHCDNPAQFYVHPIDQLSKLNQLHENLQIVSPSLPQLMNVVNGADCVSMYSVDKCWYRAKIIDAELMVLLFIDYGNTDCVSDATDIKESMWSHIEPFCLPCALPIRPKGTADWVDAANGIFNESYSKVPRLEYLTQGDHYTTSYVNMYIDGEDVAKKLIADGFARPLEYLASGCSCYISHVNGICDFFIQLERDSKALELIELYLRKKDTLKPLEGFEKGLIVAALFEDDELWYRAQLQKELPDSRYEVLFIDYGNTSTTSKCLMLSEEIASLPSLSKKCSLQLPDAYISWSPEAEAKFAELTGEGELVFTTQLLKPGQDHVTIDLLLDGENIIDRLLPLCQRKEPKEASKESLAVTTKAIITHVENTSRIYLQFSEKDSLMDIICEKLNGSKLQPKTEKAAVDDMCVVQFADDLEFYRSRILEVLEDDQYKVILIDYGNTTVVDKLYELPQEFTLIKPVAEICSMEPSAIFEKNKALTLTTFDALLDSCKGVVAVEFVNKSASPPVVRLTTKDKRSLKIYEHLQKLVQAELKLIQKRNENSECIISYGNSPKSFYVQMKHNSADLDLIVKTLQSLKKEKLKKLIDPTTNSNGVCYSQEDACYYRCSIKSVLDPSQGFEVFLLDYGNTLVVPEVWQLPQEIEPIPSLALHCQLSKIPMDVSDEKLEEAFAALLEQHFGELYEITTQPNEDETKPLIAELRINYKDFVQELVSTVTGVQKPLEAELHNCVVVQFDGPMSFYVQMESDVPALEQMTDKLLDAEQDLPAFSDLKEGALCVAQFPEDEVFYRAQIRKVLDDGKCEVHFIDFGNNAVTQQFRQLPEELAKPARYSRHCELDASTISKCDAALLQSFIDTRFSETFQVEILATKGTGTHVVRLFYQSKNISEKLQECQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
226	Phosphorylation	LWKDNPQSPVTEYNN HHCCCCCCCCCCCCC	23.69	28490779
235	Phosphorylation	VTEYNNNSIHNSKTP CCCCCCCCCCCCCCH	27.61	22817900
239	Phosphorylation	NNNSIHNSKTPMEIA CCCCCCCCCCHHHHH	24.60	22817900
269	Phosphorylation	AQRSVQVTPSRPLNA HHCCCCCCCCCCCCC	9.84	22817900
282	Phosphorylation	NADAPDYTPKHLPLV CCCCCCCCCCCCCCC	32.99	30478224
794	Phosphorylation	TRAESVISSELNKSH HHHHHHHCHHCCHHH	18.66	25749252
800	Phosphorylation	ISSELNKSHILNSTS HCHHCCHHHHCCCCC	18.06	18327897
900	Phosphorylation	SYSSGMSSPRKGNRQ CCCCCCCCCCCCCCC	21.60	22817900
912	Phosphorylation	NRQQNGRTPIQSPRH CCCCCCCCCCCCCCC	26.58	27626673
916	Phosphorylation	NGRTPIQSPRHNEKQ CCCCCCCCCCCCHHH	25.31	25749252
934	Phosphorylation	KNARFSNSESPRRSR HHCCCCCCCCCCCCC	37.95	29892262
936	Phosphorylation	ARFSNSESPRRSRDG CCCCCCCCCCCCCCC	24.43	29892262
940	Phosphorylation	NSESPRRSRDGQQGN CCCCCCCCCCCCCCC	35.68	25749252
966	Phosphorylation	QKPQRQKSTLDGNIS CCCHHCCCCCCCCCC	26.34	19429919
967	Phosphorylation	KPQRQKSTLDGNISS CCHHCCCCCCCCCCC	35.58	19429919
978	Phosphorylation	NISSKRSSGVGSDIA CCCCCCCCCCCCCCC	41.34	21082442
1557	Phosphorylation	KPAEPARTVAPQPVA CCCCCCCCCCCCCCC	24.11	28490779
1567	Phosphorylation	PQPVALKTPSPVPAE CCCCCCCCCCCCCCC	29.83	28490779
1569	Phosphorylation	PVALKTPSPVPAEPA CCCCCCCCCCCCCCC	43.70	28490779
1583	Phosphorylation	APVPKPATPVPEVVE CCCCCCCCCCCCEEE	33.09	28490779
1895	Phosphorylation	MLSEEIASLPSLSKK HHCHHHHCCCHHCCC	46.61	27794539
1898	Phosphorylation	EEIASLPSLSKKCSL HHHHCCCHHCCCCCC	51.04	27794539
1900	Phosphorylation	IASLPSLSKKCSLQL HHCCCHHCCCCCCCC	34.11	27794539

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TUD_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TUD_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TUD_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NANOS_DROME	nos	genetic	1908748
AGO3_DROME	AGO3	physical	26212455

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-226; SER-235; SER-239AND SER-800, AND MASS SPECTROMETRY.
PubMed: 18327897