TCPA_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TCPA_DROME
• UniProt AC: P12613
• Protein Name: T-complex protein 1 subunit alpha
• Gene Name: CCT1 {ECO:0000312|FlyBase:FBgn0003676}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 557
• Subcellular Localization: Cytoplasm.
• Protein Description: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin..
• Protein Sequence: MSTLASPLSIAGTRQSGASVRTQNVMAALSISNIVKSSLGPVGLDKMLVDDIGDVTVTNDGATILRLLEVEHPAAKVLVELAQLQDEEVGDGTTSVVILAAELLKNADELVKQKIHPTSIISGYRIACKEACKYISEHLTAPVDELGRDSLINIAKTSMSSKIIGADAEFFSAMVVDAAQSVKITDPRGQAAYSIKAINVLKAHGKSARESVLIPGYALNCTIASQQMPKKIVNAKIACLDFSLQKTKMKMGVQVLINDPDKLEAIRARELDITKERINMILGTGVNVVLVSGGVDDLCMKYFVEAGAMAVRRVKKSDLKIIAKATGAAFITSLTNMDGEESFDASMVGEAAEVAQERICDDELILIKGTKARAAASIILRGPNDFYCDEMERSVHDALCVVKRVLESKKVVAGGGCVEAALSIYLENFATSLASREQLAIAEFAKSLLVIPKTLSVNAAKDATDLVAKLRSYHNSSQTKPERSDLKWTGLDLIEGVVRDNKKAGVLEPAMSKIKSLKFATEAAITILRIDDMIKLNPEDKSGKSYADACAAGELDG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MSTLASPLSIAGT --CCCCCCCCCCCCC	29.50	19429919
9	Phosphorylation	STLASPLSIAGTRQS CCCCCCCCCCCCCCC	17.49	19429919
30	Phosphorylation	QNVMAALSISNIVKS HHHHHHHHHHHHHHH	21.17	21082442
150	Phosphorylation	VDELGRDSLINIAKT HHHHCHHHHHHHHHH	29.77	21082442
196	Acetylation	GQAAYSIKAINVLKA CCHHHHHHHHHHHHH	36.95	21791702
320	Acetylation	RVKKSDLKIIAKATG HCCHHCCHHHHHHCC	36.74	21791702
403	Acetylation	HDALCVVKRVLESKK HHHHHHHHHHHHCCC	19.18	21791702
469	Acetylation	DATDLVAKLRSYHNS CHHHHHHHHHHHHCC	36.63	21791702
542	Phosphorylation	KLNPEDKSGKSYADA CCCCCCCCCCCHHHH	64.87	22817900
545	Phosphorylation	PEDKSGKSYADACAA CCCCCCCCHHHHHHH	29.13	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TCPA_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TCPA_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TCPA_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TCPG_DROME	Cctgamma	physical	22036573
MST_DROME	mst	physical	26096973

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.