dbPTM

BRM_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	BRM_DROME
UniProt AC	P25439
Protein Name	ATP-dependent helicase brm
Gene Name	brm
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	1638
Subcellular Localization	Nucleus.
Protein Description	Transcriptional regulator. [PubMed: 1346755 Acts as a coactivator, assisting one or more dedicated transcriptional activators of ANTC and BXC homeotic gene clusters]
Protein Sequence	MASPSPANSPMPPPQAPSPMAPPSQSPAPSPHSPYPHQQPGPLQGPPPPGHPGAYGHPMQHGPPGQGPPGHHMPPHHQGMIFSKGPHMGMQMPPTGPNMSPYQTHGMPPNAPTQPCIVSPGGPPGGPPPPERSSQENLHALQRAIDSMEEKGLQEDPRYSQLLAMRATSKHQHLNGNQVNLLRTQITAYRLLARNKPISMQMQQALQAAQQQPPPGPPIGPPGAPGGPPPGSQHAGQPPVPPQQQQQPPPSAGTPPQCSTPPASNPYGPPVPGQKMQVAPPPPHMQQGQPLPPQPPQVGGPPPIQQQQPPQQQQQQSQPPPPEPHQHQLPNGGKPLSMGPSGGQPLIPSSPMQPQVRGTLPGMPPGSQVPQPGGGPQRQVPPAGMPMPKPNRITTVAKPVGLDPITLLQERENRIAARISLRMQELQRLPATMSEDLRLQAAIELRALRVLNFQRQLRMEFVQCTRRDTTLETALNIKLYKRTKRQGLREARATEKLEKQQKLEAERKRRQKHLEFLAAVLQHGKDLREFHRNNKAQLARMNKAVMNHHANAEREQKKEQERIEKERMRRLMAEDEEGYRKLIDQKKDKRLAFLLSQTDEYISNLTQMVKQHKDDQMKKKEEEGKRLIQFKKELLMSGEYIGIDEGSIVADMRVHVVEQCTGKKLTGDDAPMLKHLHRWLNMHPGWDWIDDEEDSCGSNDDHKPKVEEQPTATEDATDKAQATGNDEDAKDLITKAKVEDDEYRTEEQTYYSIAHTIHEKVVEQASIMVNGTLKEYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTISLVTYLMDRKKVMGPYLIIVPLSTLPNWVLEFEKWAPAVGVVSYKGSPQGRRLLQNQMRATKFNVLLTTYEYVIKDKAVLAKIQWKYMIIDEGHRMKNHHCKLTQVLNTHYIAPYRLLLTGTPLQNKLPELWALLNFLLPSIFKSCSTFEQWFNAPFATTGEKVELNEEETILIIRRLHKVLRPFLLRRLKKEVEHQLPDKVEYIIKCDMSALQRVLYKHMQSKGVLLTDGSEKGKHGKGGAKALMNTIVQLRKLCNHPFMFQHIEEKYCDHTGGHGVVSGPDLYRVSGKFELLDRILPKLKATNHRVLLFCQMTQCMTIIEDYLGWRQFGYLRLDGTTKAEDRGELLRKFNAKGSDVFVFLLSTRAGGLGLNLQTADTVVIFDSDWNPHQDLQAQDRAHRIGQRNEVRVLRLMTVNSVEERILAAARYKLNMDEKVIQAGMFDQKSTGSERQQFLQTILHQDDNEEEEENEVPDDEMINMMIARSEEEIEIFKRMDAERKKEDEEIHPGRERLIDESELPDWLTKDDDEVERFHYQYDEDTILGRGSRQRKEVDYTDSLTEKEWLKAIDDGAEFDEEEEEDDSKRKRRKRKNRKEESDDDSLILKRRRRQNLDKRSKKQMHKIMSAVIKHNQDGRTLSEPFMKLPSRQRLPDYYEIIKRPVDIKKILQRIEDCKYADLNELEKDFMQLCQNAQIYNEEASLIYLDSIALQKVFVGARQRITAAADAAAVAAGDNTGEAHGNGGSDNSDNDDDDGGDDGSDDEEIATTSAAAVKMKLKLNKSLASAPATPTQSSSNVSSGAATTSKKQTRRKRSQKKYTISDDDDDDMD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
695	Phosphorylation	WIDDEEDSCGSNDDH CCCCCCCCCCCCCCC	24.53	22817900
698	Phosphorylation	DEEDSCGSNDDHKPK CCCCCCCCCCCCCCC	41.22	22817900
1407	Phosphorylation	RKNRKEESDDDSLIL HHHHCCCCCCCHHHH	47.64	21082442
1411	Phosphorylation	KEESDDDSLILKRRR CCCCCCCHHHHHHHH	25.05	21082442
1591	Phosphorylation	MKLKLNKSLASAPAT HHHHCCHHHHCCCCC	28.26	22817900
1594	Phosphorylation	KLNKSLASAPATPTQ HCCHHHHCCCCCCCC	39.83	22817900
1598	Phosphorylation	SLASAPATPTQSSSN HHHCCCCCCCCCCCC	26.30	21082442
1627	Phosphorylation	RKRSQKKYTISDDDD HHHHCCCCCCCCCCC	19.15	22668510
1630	Phosphorylation	SQKKYTISDDDDDDM HCCCCCCCCCCCCCC	27.47	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of BRM_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of BRM_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of BRM_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BAP60_DROME	Bap60	physical	10809665
ZEST_DROME	z	physical	10809665
OSA_DROME	osa	physical	15060132
BRM_DROME	brm	physical	15060132
BAP60_DROME	Bap60	physical	15060132
ACT1_DROME	Act5C	physical	15060132
BAP60_DROME	Bap60	physical	22036573
MED17_DROME	MED17	physical	22036573
MED8_DROME	MED8	physical	22036573
EBI_DROME	ebi	physical	22036573
CPSF6_DROME	CG7185	physical	22036573
MED14_DROME	MED14	physical	22036573
DSH_DROME	dsh	physical	22036573
MED27_DROME	MED27	physical	22036573
Y1505_DROME	CG11505	physical	22036573
MED18_DROME	MED18	physical	22036573
MED23_DROME	MED23	physical	22036573
MED4_DROME	MED4	physical	22036573
MED15_DROME	MED15	physical	22036573
CDK8_DROME	Cdk8	physical	22036573
MED11_DROME	MED11	physical	22036573
MED30_DROME	MED30	physical	22036573
MED6_DROME	MED6	physical	22036573
ENC_DROME	enc	physical	22036573
MED24_DROME	MED24	physical	22036573
RBF_DROME	Rbf	physical	12093739
MYC_DROME	dm	genetic	17311883
NOTCH_DROME	N	genetic	15944353
RPB1_DROME	RpII215	genetic	15944353
BAP60_DROME	Bap60	genetic	16083904
YAP1_DROME	yki	genetic	24137538
VEIN_DROME	vn	genetic	15944353
RUVB2_DROME	rept	genetic	18259215
ASF1_DROME	asf1	genetic	12381660
ZEN1_DROME	zen	genetic	15944353
RPB2_DROME	RpII140	genetic	15944353
OSA_DROME	osa	genetic	10601025
OSA_DROME	osa	genetic	12466201
DL_DROME	Dl	genetic	15944353
DOM_DROME	dom	genetic	11262242
RUVB1_DROME	pont	genetic	18259215
GAGA_DROME	Trl	physical	23136390
ACT1_DROME	Act5C	physical	9735357
ACT1_DROME	Act5C	physical	10601025
ACT1_DROME	Act5C	physical	10809665
ACT1_DROME	Act5C	physical	27687497
RPB1_DROME	RpII215	physical	27687497
BAP60_DROME	Bap60	physical	9735357
BAP60_DROME	Bap60	physical	10601025
BAP60_DROME	Bap60	physical	23136390
SCAL_DROME	sd	physical	24137538
TIM_DROME	tim	physical	26132408
ACT2_DROME	Act42A	physical	15060132
ACT2_DROME	Act42A	physical	9735357
ACT2_DROME	Act42A	physical	10809665
YAP1_DROME	yki	physical	24137538
CLOCK_DROME	Clk	physical	26132408
TCTP_DROME	Tctp	physical	27687497
HSP7D_DROME	Hsc70-4	physical	9735357
OSA_DROME	osa	physical	10601025
OSA_DROME	osa	physical	22036573
OSA_DROME	osa	physical	10809665

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of BRM_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-695; SER-698; SER-1407;SER-1411; SER-1591 AND SER-1594, AND MASS SPECTROMETRY.	18327897 [Abstract]