RBF_DROME - dbPTM
RBF_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RBF_DROME
UniProt AC Q24472
Protein Name Retinoblastoma family protein
Gene Name Rbf
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 845
Subcellular Localization Nucleus .
Protein Description Functions in cell cycle regulation. Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. In follicle cells, the complex plays a central role in the site-specific DNA replication at the chorion loci. During development, the complex represses transcription of developmentally controlled E2F target genes..
Protein Sequence MSEPDPQELGAEVVSGLVATSDDRLEMINAEYTNLCRDLNMDRQTELQGYETYLEVSQRCSMEGTASHWMCCAIYTACRRTSTPTVTGQNAVVKGNCVSLNNLLRCCKMSIYEFKTKIKQWCDMANLPQEFVNEIEDLDRKFSITFMLHKRFRIIMDMIFSCPPNEKKHSKYISLHGNHAHGKCSYIKLDDICWRLFLCAKNQKPSNTVDLVTSYNLMICCIDLIYNNVLAEKRTDLINPKFEGLPSNWTELDFRHNPHCILSNFCDMTEEAKAMKATTFRQIMSSFFQASTIYGNKDTMLGLLANENFERNLKSLNISYEQYVLSVGEFDERILSAYDAGEHTALNDQSLRPPVTPLTRKQDLPAQPAMAGDKFEPVRNATNNVKQLSAFGRITEPTDFVKQAGEEVIAKLLSIIEEIEQKFLAKYPSTEAKSRFQLAKSFFFYLLDQILQAEIRNKPDIDLKRLLVQKVSLVIFNITLMACCVELVLEAYKTELKFPWVLDCFSISAFEFQKIIEIVVRHGSHEGCLNRSLIKHLNSIEETCLERLAWARNSTVWEMIASAQLPLPTWLMVNLDRAAGPLQIFLRKVYLLGWLRIQKLCSELSLCEKTPESIWHIFEHSITHETELMKDRHLDQNIMCAIYIYIRVKRMEDPKFSDIMRAYRNQPQAVNSVYREVFIDINEDGEPKVKDIIHFYNHTYVPLMRQFVIDYLNVTPDVSGRASDLQLSPHPKERAAQPKKVTQSHSLFVSQMSKNEIQQSPNQMVYSFCRSPAKDLQAMNEKVRGGKRMLSFGDEPGLGTMAETKRSKISQVKAVMDDPELQSAEQQTAVTTEGCVGGEGGEHET
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSEPDPQEL
------CCCCCHHHH		58.8119429919
15PhosphorylationELGAEVVSGLVATSD
HHCHHHHHHHEECCC		31.4219429919
356PhosphorylationQSLRPPVTPLTRKQD
CCCCCCCCCCCCCCC		20.5318327897
359PhosphorylationRPPVTPLTRKQDLPA
CCCCCCCCCCCCCCC		36.7022817900
728PhosphorylationRASDLQLSPHPKERA
CCCCCCCCCCHHHCC		14.2719429919
760PhosphorylationSKNEIQQSPNQMVYS
CHHHHHCCCCHHHHH		14.9419429919
767PhosphorylationSPNQMVYSFCRSPAK
CCCHHHHHHHCCHHH		13.3722817900
771PhosphorylationMVYSFCRSPAKDLQA
HHHHHHCCHHHHHHH		30.3222817900
791PhosphorylationRGGKRMLSFGDEPGL
HCCCCCCCCCCCCCC		20.1719429919
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RBF_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RBF_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RBF_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TFDP_DROMEDpphysical
15479636
CAF1_DROMECaf1physical
15479636
E2F2_DROMEE2f2physical
15479636
LIN54_DROMEmip120physical
15479636
HDAC1_DROMERpd3physical
15456884
CAF1_DROMECaf1physical
15456884
TFDP_DROMEDpphysical
15456884
E2F1_DROMEE2fphysical
15456884
E2F2_DROMEE2f2physical
15456884
BRM_DROMEbrmphysical
12093739
ARM_DROMEarmgenetic
24809668
SGG_DROMEsgggenetic
24809668
NOTCH_DROMENgenetic
23550128
HEP_DROMEhepgenetic
25089524
HRS_DROMEHrsgenetic
27056762
AFF4_DROMElilligenetic
23550128
NOS_DROMENosgenetic
15256486
CCNE_DROMECycEgenetic
23550128
ECR_DROMEEcRgenetic
23550128
PABP2_DROMEPabp2genetic
23550128
PTC_DROMEptcgenetic
12015606
TFDP_DROMEDpgenetic
18688282
MAM_DROMEmamgenetic
23550128
RHOM_DROMErhogenetic
27056762
HID_DROMEWgenetic
19100727
RPR_DROMErprgenetic
18688282
PUM_DROMEpumgenetic
23550128
SQD_DROMEsqdgenetic
19364495
E2F1_DROMEE2fgenetic
10603353
E2F1_DROMEE2fgenetic
12881421
E2F1_DROMEE2fgenetic
23550128
AXN_DROMEAxngenetic
24809668
LOLA1_DROMElolagenetic
23550128
LOLA2_DROMElolagenetic
23550128
LOLA3_DROMElolagenetic
23550128
LOLA4_DROMElolagenetic
23550128
LOLA6_DROMElolagenetic
23550128
LOLA5_DROMElolagenetic
23550128
JNK_DROMEbskgenetic
25089524
DOM_DROMEdomgenetic
23550128
RHEB_DROMERhebgenetic
20808898
GAGA_DROMETrlphysical
23070566
MYB_DROMEMybphysical
15479636
EBI_DROMEebiphysical
23919509
E2F2_DROMEE2f2physical
20861300
E2F2_DROMEE2f2physical
21325133
TFDP_DROMEDpphysical
25242320
TFDP_DROMEDpphysical
17185321
UBIQP_DROMEUbi-p63Ephysical
23086928
ORC2_DROMEOrc2physical
18665226
E2F1_DROMEE2fphysical
25242320
E2F1_DROMEE2fphysical
17185321
E2F1_DROMEE2fphysical
17517653
E2F1_DROMEE2fphysical
20861300
E2F1_DROMEE2fphysical
24027329
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RBF_DROME

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-356; THR-359; SER-760AND SER-771, AND MASS SPECTROMETRY.

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