dbPTM

E2F1_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	E2F1_DROME
UniProt AC	Q27368
Protein Name	Transcription factor E2f1
Gene Name	E2f1 {ECO:0000312\|FlyBase:FBgn0011766}
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	805
Subcellular Localization	Nucleus.
Protein Description	Transcriptional activator that binds to E2f sites. Required for wild-type growth in mitotic and polytene tissues, Contributes to the expression of replication genes at the G1-S transition and Cyclin E. Activates cell proliferation in wing imaginal disk, which requires expression of vg..
Protein Sequence	MSKFFVNVAPINNSNSSSSHTTTSSNTQRHQQHQQHYGGSGTTGHTMVARRLNYDLHGGTTSINNNNNIVIKNESVDLDYDHVLSSSDSNSNGGVAAHLRDHVYISLDKGHNTGAVATAAAAATAGHTQQQLQQQHHHQNQQQRKATGKSNDITNYYKVKRRPHAVSDEIHPKKQAKQSAHHQTVYQKHTASSAPQQLRHSHHQLRHDADAELDEDVVERVAKPASHHPFSLSTPQQQLAASVASSSSSGDRNRADTSLGILTKKFVDLLQESPDGVVDLNEASNRLHVQKRRIYDITNVLEGINILEKKSKNNIQWRCGQSMVSQERSRHIEADSLRLEQQENELNKAIDLMRENLAEISQEVENSGGMAYVTQNDLLNVDLFKDQIVIVIKAPPEAKLVLPNTKLPREIYVKAENSGEINVFLCHDTSPENSPIAPGAGYVGAPGAGCVRTATSTRLHPLTNQRLNDPLFNNIDAMSTKGLFQTPYRSARNLSKSIEEAAKQSQPEYNNICDIAMGQHHNLNQQQQQQQQQLLQQPEEDDVDVELNQLVPTLTNPVVRTHQFQQHQQPSIQELFSSLTESSPPTPTKRRREAAAAAIAAGSSTTATTTLNSHNNRNHSNHSNHSNHSSSNNSKSQPPTIGYGSSQRRSDVPMYNCAMEGATTTSATADTTAATSRSAAASSLQMQFAAVAESNNGSSSGGGGGGGGYGSIAGAGANADPHQPYSHDRNSLPPGVADCDANSNSSSVTLQGLDALFNDIGSDYFSNDIAFVSINPPDDNDYPYALNANEGIDRLFDFGSDAYGP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	Reference
430	Phosphorylation	VFLCHDTSPENSPIA EEEEECCCCCCCCCC	22817900
434	Phosphorylation	HDTSPENSPIAPGAG ECCCCCCCCCCCCCC	22817900
463	Phosphorylation	STRLHPLTNQRLNDP CCCCCCCCCCCCCCC	22817900
620	Phosphorylation	SHNNRNHSNHSNHSN CCCCCCCCCCCCCCC	22668510
643	Phosphorylation	SQPPTIGYGSSQRRS CCCCCCCCCCCCCCC	22668510
646	Phosphorylation	PTIGYGSSQRRSDVP CCCCCCCCCCCCCCC	22668510

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	l(2)dtl	Q24371	PMID:22199232
-	K	Ubiquitination	E3 ubiquitin ligase	moi	B7Z0L8	PMID:19081076

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of E2F1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of E2F1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RBF_DROME	Rbf	genetic	10603353
RBF_DROME	Rbf	genetic	12651890
RBF_DROME	Rbf	genetic	17112319
RBF_DROME	Rbf	genetic	18688282
ARM_DROME	arm	genetic	18794899
SGG_DROME	sgg	genetic	18794899
SMO_DROME	smo	genetic	17923695
PIWI_DROME	piwi	genetic	19902126
ESC_DROME	esc	genetic	23275887
CCNE_DROME	CycE	genetic	10197983
CCNE_DROME	CycE	genetic	23275887
API5_DROME	Aac11	genetic	17112319
E2F2_DROME	E2f2	genetic	11511545
E2F2_DROME	E2f2	genetic	12651890
E2F2_DROME	E2f2	genetic	17923695
SUZ2_DROME	Su(z)2	genetic	23275887
TFDP_DROME	Dp	genetic	9657151
TFDP_DROME	Dp	genetic	17112319
TFDP_DROME	Dp	genetic	11511545
ASX_DROME	Asx	genetic	23275887
CDK8_DROME	Cdk8	genetic	18794899
CCNA_DROME	CycA	genetic	23275887
BRM_DROME	brm	genetic	23275887
DIAP1_DROME	th	genetic	17112319
HID_DROME	W	genetic	22916021
CHDM_DROME	Mi-2	genetic	23275887
PC_DROME	Pc	genetic	23275887
SCM_DROME	Scm	genetic	23275887
SRR55_DROME	B52	genetic	19546319
TRX_DROME	trx	genetic	23275887
UBCD1_DROME	eff	genetic	23275887
H2AV_DROME	His2Av	genetic	23275887
DOA_DROME	Doa	genetic	19546319
PANG1_DROME	pan	genetic	18794899
PANG2_DROME	pan	genetic	18794899
PHO_DROME	pho	genetic	23275887
DDX3_DROME	bel	genetic	17923695
DDX3_DROME	bel	genetic	19546319
SUZ12_DROME	Su(z)12	genetic	23275887
GAGA_DROME	Trl	physical	23070566
RBF_DROME	Rbf	physical	18665226
RBF_DROME	Rbf	physical	8675008
TFDP_DROME	Dp	physical	8022787
TFDP_DROME	Dp	physical	8675008
CDK8_DROME	Cdk8	physical	18794899
ORC2_DROME	Orc2	physical	11231579

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of E2F1_DROME

Related Literatures of Post-Translational Modification