SRR55_DROME - dbPTM
SRR55_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SRR55_DROME
UniProt AC P26686
Protein Name Serine-arginine protein 55
Gene Name B52
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 376
Subcellular Localization Nucleus . Associated with boundaries of transcriptionally active chromatin.
Protein Description Essential for development. May have a critical role in splicing or in controlling alternative splice site use of at least some pre-mRNA in vivo. Not required for all splicing. May play a general role in the condensation or decondensation of chromatin..
Protein Sequence MVGSRVYVGGLPYGVRERDLERFFKGYGRTRDILIKNGYGFVEFEDYRDADDAVYELNGKELLGERVVVEPARGTARGSNRDRYDDRYGGRRGGGGGRYNEKNKNSRSSSRYGPPLRTEYRLIVENLSSRVSWQDLKDYMRQAGEVTYADAHKQRRNEGVVEFASLSDMKTAIEKLDDTELNGRRIHLVEDRRGGRSGGGGGSGRGRSRSSSSRSRSRSRRRSRSRRSSHSRSKSRSRSKSRGGRSKSKSPVKSRSRSRSRSNKSRDVSKSKSKSHSRTRSRSPKRERDSRSRSRSVSKRESRSRSRSKSIHRDSRSRPPTVSFKSSFYKFTTMPFFCSDRSASAENKSRSRSRSRSASPKNGNASPDRNNESMDD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
25AcetylationRDLERFFKGYGRTRD
HHHHHHHHCCCCHHH		48.8121791702
103 (in isoform 6)Phosphorylation-42.4327626673
103 (in isoform 4)Phosphorylation-42.4327626673
103 (in isoform 2)Phosphorylation-42.4327626673
128PhosphorylationRLIVENLSSRVSWQD
HHHHHCHHHCCCHHH		27.9022668510
129PhosphorylationLIVENLSSRVSWQDL
HHHHCHHHCCCHHHH		39.6123607784
132PhosphorylationENLSSRVSWQDLKDY
HCHHHCCCHHHHHHH		20.2219429919
165PhosphorylationEGVVEFASLSDMKTA
CCCEEEECHHHHHHH		33.4512537569
178 (in isoform 7)Phosphorylation-53.1419429919
182 (in isoform 7)Phosphorylation-35.3819429919
184 (in isoform 7)Phosphorylation-33.0519429919
228PhosphorylationRRSRSRRSSHSRSKS
HHHHHHHHHHCHHHH		31.1519429919
229PhosphorylationRSRSRRSSHSRSKSR
HHHHHHHHHCHHHHH		24.5419429919
231PhosphorylationRSRRSSHSRSKSRSR
HHHHHHHCHHHHHHC		39.9519429919
233PhosphorylationRRSSHSRSKSRSRSK
HHHHHCHHHHHHCCC		37.6919429919
269PhosphorylationSNKSRDVSKSKSKSH
CCCCCCCHHHHCCCC		35.1919429919
290PhosphorylationSPKRERDSRSRSRSV
CCHHHHHHHHHHHCH		38.0719429919
292PhosphorylationKRERDSRSRSRSVSK
HHHHHHHHHHHCHHH		38.2619429919
294PhosphorylationERDSRSRSRSVSKRE
HHHHHHHHHCHHHHH		30.1019429919
296PhosphorylationDSRSRSRSVSKRESR
HHHHHHHCHHHHHHH		31.8019429919
298PhosphorylationRSRSRSVSKRESRSR
HHHHHCHHHHHHHHH		27.5219429919
302PhosphorylationRSVSKRESRSRSRSK
HCHHHHHHHHHHHHC		39.3219429919
308PhosphorylationESRSRSRSKSIHRDS
HHHHHHHHCCCCCCC		31.8119429919
310PhosphorylationRSRSRSKSIHRDSRS
HHHHHHCCCCCCCCC		25.5219429919
312 (in isoform 2)Phosphorylation-34.2919429919
315PhosphorylationSKSIHRDSRSRPPTV
HCCCCCCCCCCCCEE		31.9219429919
316 (in isoform 2)Phosphorylation-40.7619429919
317 (in isoform 5)Phosphorylation-53.7619429919
318 (in isoform 2)Phosphorylation-39.8619429919
321 (in isoform 5)Phosphorylation-31.3119429919
323 (in isoform 5)Phosphorylation-29.4519429919
342PhosphorylationPFFCSDRSASAENKS
CEECCCCCCCCCHHH		31.4019429919
344PhosphorylationFCSDRSASAENKSRS
ECCCCCCCCCHHHHH		37.0419429919
349PhosphorylationSASAENKSRSRSRSR
CCCCCHHHHHHHHCC		47.2519429919
355PhosphorylationKSRSRSRSRSASPKN
HHHHHHHCCCCCCCC		31.6522817900
366PhosphorylationSPKNGNASPDRNNES
CCCCCCCCCCCCCCC		31.1919429919
373PhosphorylationSPDRNNESMDD----
CCCCCCCCCCC----		29.6319429919
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SRR55_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SRR55_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SRR55_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TOP1_DROMETop1genetic
20862310
RX21_DROMERsf1genetic
10090730
ECR_DROMEEcRphysical
12655012
RX_DROMERxphysical
12655012
SDC_DROMESdcphysical
12655012
HTH_DROMEhthphysical
12655012
LOLA1_DROMElolaphysical
12655012
LOLA2_DROMElolaphysical
12655012
LOLA3_DROMElolaphysical
12655012
LOLA4_DROMElolaphysical
12655012
LOLA6_DROMElolaphysical
12655012
LOLA5_DROMElolaphysical
12655012
FRIZ_DROMEfzphysical
12655012
FUR11_DROMEFur1physical
12655012
FUR1C_DROMEFur1physical
12655012
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SRR55_DROME

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165, AND MASSSPECTROMETRY.

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