FUR1C_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FUR1C_DROME
• UniProt AC: P30430
• Protein Name: Furin-like protease 1, isoform 1-CRR
• Gene Name: Fur1
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1101
• Subcellular Localization: Golgi apparatus membrane ; Multi-pass membrane protein .
• Protein Description: Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif..
• Protein Sequence: MKNDVVRWSRQPTSNTTNSSSSSRSDSNSTHKHRSKSNKLNARQLGSNAARSCQQRSSVATTLEDEQQTIIECDIGNFNFDCNLFKTSFLTQHKQKRSGKSSSKSKSNRSRPLAKTKAVFLLALQFSAVVFLCNINVGFVAGSVATAASSAGGSSPAAPSSAPSSPPTVAVPPPPPPSSALKVDPNGQSPVLPPYVLDYETGGKAKLTPNNGKFGQSGSSGSNNNHIVGHYTHTWAVHIPNGDNGMADAVAKDHGFVNLGKIFDDHYHFAHHKVSKRSLSPATHHQTRLDDDDRVHWAKQQRAKSRSKRDFIRMRPSRTSSRAMSMVDAMSFNDSKWPQMWYLNRGGGLDMNVIPAWKMGITGKGVVVTILDDGLESDHPDIQDNYDPKASYDVNSHDDDPMPHYDMTDSNRHGTRCAGEVAATANNSFCAVGIAYGASVGGVRMLDGDVTDAVEARSLSLNPQHIDIYSASWGPDDDGKTVDGPGELASRAFIEGTTKGRGGKGSIFIWASGNGGREQDNCNCDGYTNSIWTLSISSATEEGHVPWYSEKCSSTLATTYSSGGQGEKQVVTTDLHHSCTVSHTGTSASAPLAAGIAALVLQSNQNLTWRDLQHIVVRTAKPANLKDPSWSRNGVGRRVSHSFGYGLMDAAEMVRVARNWKAVPEQQRCEINAPHVDKVIPPRTHITLQLTVNHCRSVNYLEHVQAKITLTSQRRGDIQLFLRSPANTSVTLLTPRIHDNSRSGFNQWPFMSVHTWGESPQGNWQLEIHNEGRYMAQITQWDMIFYGTETPAQPDDVANPSQSNQFNLYGNDMAHNDVEYDSTGQWRNMQQVGEVGMTRDHSNTAACLKWSDRKCLECNDSAYMFEDQCYDVCPVHTYPLDKFQAEEDEQDDEVTRGPVNPYSSSPMDHSLLMSNSLDDKQDPLQAEDRRRRSSLTQLVEVPSRVCAACDRSCLECYGALASQCSTCSPGSQLRKILNETFCYAYVVRSTGMASVVDISKMDDRDTQQYMTGTTVLLLVSVIFTLMGVAVAGGIVYHRRAMARSNELYSRVSLVPGDESDSDEDELFTAHFPARKSGVNIYRDEAPSEKIFEEDEISHLVP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	N-linked_Glycosylation	WSRQPTSNTTNSSSS ECCCCCCCCCCCCCC	54.09	-
18	N-linked_Glycosylation	QPTSNTTNSSSSSRS CCCCCCCCCCCCCCC	37.54	-
28	N-linked_Glycosylation	SSSRSDSNSTHKHRS CCCCCCCCCCCCHHH	56.79	-
108	N-linked_Glycosylation	SSSKSKSNRSRPLAK CCCCCCCCCCCHHHH	50.08	-
333	N-linked_Glycosylation	MVDAMSFNDSKWPQM HHHHHCCCCCCCCCE	45.39	-
426	N-linked_Glycosylation	GEVAATANNSFCAVG HHHHHCCCCCCEEEE	40.08	-
606	N-linked_Glycosylation	LVLQSNQNLTWRDLQ HHHHCCCCCCHHHHH	43.62	-
727	N-linked_Glycosylation	LFLRSPANTSVTLLT EEEECCCCCEEEEEC	35.95	-
859	N-linked_Glycosylation	DRKCLECNDSAYMFE CCCCEECCCCEEECC	36.58	-
978	N-linked_Glycosylation	SQLRKILNETFCYAY HHHHHHHHHHCCEEE	50.14	-
1048	Phosphorylation	MARSNELYSRVSLVP HHHCCCCHHCEEECC	6.56	25749252
1052	Phosphorylation	NELYSRVSLVPGDES CCCHHCEEECCCCCC	23.65	23607784
1059	Phosphorylation	SLVPGDESDSDEDEL EECCCCCCCCCHHHC	47.34	19429919
1061	Phosphorylation	VPGDESDSDEDELFT CCCCCCCCCHHHCCC	52.78	19429919
1068	Phosphorylation	SDEDELFTAHFPARK CCHHHCCCCCCCCHH	31.67	23607784

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FUR1C_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FUR1C_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FUR1C_DROME !!

Protein-Protein Interaction

Oops, there are no PPI records of FUR1C_DROME !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.