| UniProt ID | LOLA4_DROME | |
|---|---|---|
| UniProt AC | Q867Z4 | |
| Protein Name | Longitudinals lacking protein, isoforms F/I/K/T | |
| Gene Name | lola {ECO:0000312|FlyBase:FBgn0283521} | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 970 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Putative transcription factor required for axon growth and guidance in the central and peripheral nervous systems. Repels CNS axons away from the midline by promoting the expression of the midline repellent sli and its receptor robo.. | |
| Protein Sequence | MDDDQQFCLRWNNHQSTLISVFDTLLENETLVDCTLAAEGKFLKAHKVVLSACSPYFATLLQEQYDKHPIFILKDVKYQELRAMMDYMYRGEVNISQDQLAALLKAAESLQIKGLSDNRTGGGVAPKPESSGHHRGGKLSGAYTLEQTKRARLATGGAMDTSGDVSGSREGSSSPSRRRRKVRRRSMENDAHDNSNSSVLQAAASNQSILQQTGAGLAVSALVTTQLSSGPAAGTSSQASSTQQQQPLTSTNVTKKTESAKLTSSTAAPASGASASAAVQQAHLHQQQAQTTSDAINTENVQAQSQGGAQGVQGDDEDIDEGSAVGGPNSATGPNPASASASAVHAGVVVKQLASVVDKSSSNHKHKIKDNSVSSVGSEMVIEPKAEYDDDAHDENVEDLTLDEEDMTMEELDQTAGTSQGGEGSSQTYATWQHDRSQDELGLMAQDAQQRDPQASKQDKGEQTEGAQDEFELDDCLLESNDIVITQNKDGFVLHVKKLGNITAAKLEENQAVAQQQGQAAVTVTGPAGQPTPTITELLNAAAASHSEPKPTLTTLTSTPIKLPSSECELINIKKIIPATTTIATHHPHTSSTIIHPHHIIQHVSQEPHHQEHHQQHQTIHIEEVPQTSQQHHQQQHHHQLQTVQPTHTQVQSIITAHPGQTINLVGLRNVQLADSKPIASRIRYSRGKIIGPTVQNLQIVETHEPIQHQHHELSDGTKYEISEIDLNNPNASAAIISDLVKYAEIDDIELPDGTKIGIGFAPSEITEHMQTSGGETHITTIEHEPQELQTVHQHEQTQQTHHIHAGQLQTHHIQTVVQSSSGQQQHDQQQHHQHHSIELQDDDGVETITPEELGMHDSSKSYTILTTRPMKEESEHDPSGMTYELSLSDSSLGPCDDPESRYVCRHCGKKYRWKSTLRRHENVECGGKEPCHPCPYCSYKAKQRGNLGVHVRKHHPEKPQLESKRGRKV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 140 | Phosphorylation | HHRGGKLSGAYTLEQ CCCCCCCCCCEEHHH | 25.51 | 19429919 | |
| 161 | Phosphorylation | ATGGAMDTSGDVSGS HCCCCCCCCCCCCCC | 22.86 | 22817900 | |
| 162 | Phosphorylation | TGGAMDTSGDVSGSR CCCCCCCCCCCCCCC | 28.82 | 22817900 | |
| 166 | Phosphorylation | MDTSGDVSGSREGSS CCCCCCCCCCCCCCC | 35.47 | 29892262 | |
| 168 | Phosphorylation | TSGDVSGSREGSSSP CCCCCCCCCCCCCCH | 21.47 | 25749252 | |
| 172 | Phosphorylation | VSGSREGSSSPSRRR CCCCCCCCCCHHHHH | 23.92 | 22668510 | |
| 173 | Phosphorylation | SGSREGSSSPSRRRR CCCCCCCCCHHHHHH | 58.06 | 22668510 | |
| 174 | Phosphorylation | GSREGSSSPSRRRRK CCCCCCCCHHHHHHH | 28.70 | 22668510 | |
| 372 | Phosphorylation | KHKIKDNSVSSVGSE CCCCCCCCCCCCCCE | 33.25 | 19429919 | |
| 374 | Phosphorylation | KIKDNSVSSVGSEMV CCCCCCCCCCCCEEE | 21.08 | 19429919 | |
| 375 | Phosphorylation | IKDNSVSSVGSEMVI CCCCCCCCCCCEEEE | 28.48 | 19429919 | |
| 378 | Phosphorylation | NSVSSVGSEMVIEPK CCCCCCCCEEEECCC | 21.99 | 19429919 | |
| 437 | Phosphorylation | ATWQHDRSQDELGLM EEEECCCCHHHHHHH | 48.30 | 19429919 | |
| 677 | Acetylation | NVQLADSKPIASRIR CCCCCCCCCCHHHHH | 40.78 | 21791702 | |
| 889 | Phosphorylation | MTYELSLSDSSLGPC CEEEEEECCCCCCCC | 31.88 | 22817900 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of LOLA4_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of LOLA4_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of LOLA4_DROME !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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