dbPTM

KGP24_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	KGP24_DROME
UniProt AC	Q03043
Protein Name	cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B
Gene Name	for
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	1088
Subcellular Localization
Protein Description
Protein Sequence	MRFCFDRLCFATKRPAQNSNSNAPHSSTTVDAPPRPADVDVATVPVATPAPPPQQPVSNLFYADYQKLQPAIIDRDWERDRDTDTDTRSEAKPPDIVEHIEPVEEQRQIHTQIQSPAEIQIQIPPTPPAPSIQIQIQQRYRRHSSAEDRNLNTRRNDSNITEALRKAASMQQEPNANYQFPTDLGLVSIVNNNNNTNTHPSGSNSGSNNNSNINNNLVGGIVTLPAAGGLIGLEHTASGLRLIPAPPTHSDVLTHTLIYGTPPSGAQQLNQDPRSLLHQQELQLQQRYQQLQQLQAQTQGLYTSQGSPVLYHQPSPGSSQPVAIPGATCHSPTQLQPPNTLNLQQQMQSLRISGCTPSGTGGSATPSPVGLVDPNFIVSNYVAASPQEERFIQIIQAKELKIQEMQRALQFKDNEIAELKSHLDKFQSVFPFSRGSAAGCAGTGGASGSGAGGSGGSGPGTATGATRKSGQNFQRQRALGISAEPQSESSLLLEHVSFPKYDKDERSRELIKAAILDNDFMKNLDLTQIREIVDCMYPVKYPAKNLIIKEGDVGSIVYVMEDGRVEVSREGKYLSTLSGAKVLGELAILYNCQRTATITAITECNLWAIERQCFQTIMMRTGLIRQAEYSDFLKSVPIFKDLAEDTLIKISDVLEETHYQRGDYIVRQGARGDTFFIISKGKVRVTIKQQDTQEEKFIRMLGKGDFFGEKALQGDDLRTANIICESADGVSCLVIDRETFNQLISNLDEIKHRYDDEGAMERRKINEEFRDINLTDLRVIATLGVGGFGRVELVQTNGDSSRSFALKQMKKSQIVETRQQQHIMSEKEIMGEANCQFIVKLFKTFKDKKYLYMLMESCLGGELWTILRDKGNFDDSTTRFYTACVVEAFDYLHSRNIIYRDLKPENLLLNERGYVKLVDFGFAKKLQTGRKTWTFCGTPEYVAPEVILNRGHDISADYWSLGVLMFELLTGTPPFTGSDPMRTYNIILKGIDAIEFPRNITRNASNLIKKLCRDNPAERLGYQRGGISEIQKHKWFDGFYWWGLQNCTLEPPIKPAVKSVVDTTNFDDYPPDPEGPPPDDVTGWDKDF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
934	Phosphorylation	QTGRKTWTFCGTPEY CCCCCEEEECCCCHH	17.80	22817900
938	Phosphorylation	KTWTFCGTPEYVAPE CEEEECCCCHHCCCH	17.71	19060867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of KGP24_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of KGP24_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of KGP24_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LOLA1_DROME	lola	physical	14605208
LOLA2_DROME	lola	physical	14605208
LOLA3_DROME	lola	physical	14605208
LOLA4_DROME	lola	physical	14605208
LOLA6_DROME	lola	physical	14605208
LOLA5_DROME	lola	physical	14605208
MERH_DROME	Mer	physical	14605208
HSP6A_DROME	Hsp67Ba	physical	14605208
RS3_DROME	RpS3	physical	14605208
GBLP_DROME	Rack1	physical	14605208
FOXO_DROME	foxo	genetic	22393355
LOLA1_DROME	lola	genetic	27098704
LOLA2_DROME	lola	genetic	27098704
LOLA3_DROME	lola	genetic	27098704
LOLA4_DROME	lola	genetic	27098704
LOLA6_DROME	lola	genetic	27098704
LOLA5_DROME	lola	genetic	27098704
LOLA1_DROME	lola	physical	27098704
LOLA2_DROME	lola	physical	27098704
LOLA3_DROME	lola	physical	27098704
LOLA4_DROME	lola	physical	27098704
LOLA6_DROME	lola	physical	27098704
LOLA5_DROME	lola	physical	27098704

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of KGP24_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-934 AND THR-938, ANDMASS SPECTROMETRY.	18327897 [Abstract]