dbPTM

LOLA3_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	LOLA3_DROME
UniProt AC	Q7KQZ4
Protein Name	Longitudinals lacking protein, isoforms A/B/D/L
Gene Name	lola {ECO:0000312\|FlyBase:FBgn0283521}
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	787
Subcellular Localization	Nucleus .
Protein Description	Putative transcription factor required for axon growth and guidance in the central and peripheral nervous systems. Repels CNS axons away from the midline by promoting the expression of the midline repellent sli and its receptor robo..
Protein Sequence	MDDDQQFCLRWNNHQSTLISVFDTLLENETLVDCTLAAEGKFLKAHKVVLSACSPYFATLLQEQYDKHPIFILKDVKYQELRAMMDYMYRGEVNISQDQLAALLKAAESLQIKGLSDNRTGGGVAPKPESSGHHRGGKLSGAYTLEQTKRARLATGGAMDTSGDVSGSREGSSSPSRRRRKVRRRSMENDAHDNSNSSVLQAAASNQSILQQTGAGLAVSALVTTQLSSGPAAGTSSQASSTQQQQPLTSTNVTKKTESAKLTSSTAAPASGASASAAVQQAHLHQQQAQTTSDAINTENVQAQSQGGAQGVQGDDEDIDEGSAVGGPNSATGPNPASASASAVHAGVVVKQLASVVDKSSSNHKHKIKDNSVSSVGSEMVIEPKAEYDDDAHDENVEDLTLDEEDMTMEELDQTAGTSQGGEGSSQTYATWQHDRSQDELGLMAQDAQQRDPQDLSITRIAGLTWNEWNARLAMPLVTLREGVQPLVFPTDLSVDKQQGAAGLTAKDVNVSGRKTPTDGGGCKSEPRAASTPARTHSSSNHSSNGNGSGKPTKTSSGGKLNHLTEEEATALMLKAVAEKQAAAAAGTELSFGEDQASSGNGNSSDYPATLSGAVTFADVGGPAGLCHINILNSISAMNNLISGSTAAGVGITTGSGQSPSNSGHNNSAGGGSSVLGGADNGAGHPCPVCGRVYKLKSSLRNHQKWECGKEPQFQCPFCVYRAKQKMHIGRHMERMHKEKFKLEDVKNFAGSSGLDGDSSGATATAASVVAAAAALVSGVELHPHFS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
463 (in isoform 3)	Phosphorylation	-	22.67	18327897
467 (in isoform 3)	Phosphorylation	-	38.89	18327897
516	Phosphorylation	VNVSGRKTPTDGGGC EECCCCCCCCCCCCC	30.02	22668510
619 (in isoform 3)	Phosphorylation	-	35.09	18327897

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of LOLA3_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of LOLA3_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of LOLA3_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LOLA1_DROME	lola	physical	14605208
LOLA2_DROME	lola	physical	14605208
LOLA3_DROME	lola	physical	14605208
LOLA4_DROME	lola	physical	14605208
LOLA6_DROME	lola	physical	14605208
LOLA5_DROME	lola	physical	14605208
MILT_DROME	milt	physical	14605208
Y2199_DROME	CG2199	physical	14605208
MED9_DROME	MED9	physical	14605208
GIANT_DROME	gt	physical	14605208
SLIT_DROME	sli	genetic	11880341
KGP25_DROME	for	genetic	27098704
KGP24_DROME	for	genetic	27098704
JIL1_DROME	JIL-1	physical	12538650
LOLA1_DROME	lola	physical	12538650
LOLA2_DROME	lola	physical	12538650
LOLA3_DROME	lola	physical	12538650
LOLA4_DROME	lola	physical	12538650
LOLA6_DROME	lola	physical	12538650
LOLA5_DROME	lola	physical	12538650
LOLA1_DROME	lola	physical	23847101
LOLA2_DROME	lola	physical	23847101
LOLA3_DROME	lola	physical	23847101
LOLA4_DROME	lola	physical	23847101
LOLA6_DROME	lola	physical	23847101
LOLA5_DROME	lola	physical	23847101
LOLA1_DROME	lola	physical	27898696
LOLA2_DROME	lola	physical	27898696
LOLA3_DROME	lola	physical	27898696
LOLA4_DROME	lola	physical	27898696
LOLA6_DROME	lola	physical	27898696
LOLA5_DROME	lola	physical	27898696
KGP25_DROME	for	physical	27098704
KGP24_DROME	for	physical	27098704

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of LOLA3_DROME

Related Literatures of Post-Translational Modification