dbPTM

KGP25_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	KGP25_DROME
UniProt AC	P32023
Protein Name	cGMP-dependent protein kinase, isozyme 2 forms cD5/T2
Gene Name	for
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	934
Subcellular Localization
Protein Description
Protein Sequence	MKIKHYPGKAVDASLSLEGSSAMGALYEANWLRAANQPAAPATTGTKLSRQSSSAGSSFLIEGISALSKYQMTLENIRQLELQSRDKRIASTIKELSGYRPSALQHHQQQQMHNVWVAEDQDQEHEELEDASEGKEKLASIQEPPAVNHYVLDPTERPRVPRPRQQFSVKPPSLRRSQTMSQPPSYATLRSPPKIKENLSKSSSAYSTFSSAAEDSQDQVVICQQPQRLMAPPPREPPPEPPKRVSKPLSRSQTSVQRYATVRMPNQTTSFSRSVVRSRDSTASQRRLSLEQAIEGLKLEGEKAVRQKSPQISPAASSNGSSKDLNGEGFCIPRPRLIVPVHTYARRRRTGNLKEQSSGGQEEEAEKGKGWKDFYVLSQDRHSSFYINRIGQNYDYDYPINFNIFSPDGRVEVSREGKYLSTLSGAKVLGELAILYNCQRTATITAITECNLWAIERQCFQTIMMRTGLIRQAEYSDFLKSVPIFKDLAEDTLIKISDVLEETHYQRGDYIVRQGARGDTFFIISKGKVRVTIKQQDTQEEKFIRMLGKGDFFGEKALQGDDLRTANIICESADGVSCLVIDRETFNQLISNLDEIKHRYDDEGAMERRKINEEFRDINLTDLRVIATLGVGGFGRVELVQTNGDSSRSFALKQMKKSQIVETRQQQHIMSEKEIMGEANCQFIVKLFKTFKDKKYLYMLMESCLGGELWTILRDKGNFDDSTTRFYTACVVEAFDYLHSRNIIYRDLKPENLLLNERGYVKLVDFGFAKKLQTGRKTWTFCGTPEYVAPEVILNRGHDISADYWSLGVLMFELLTGTPPFTGSDPMRTYNIILKGIDAIEFPRNITRNASNLIKKLCRDNPAERLGYQRGGISEIQKHKWFDGFYWWGLQNCTLEPPIKPAVKSVVDTTNFDDYPPDPEGPPPDDVTGWDKDF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
289	Phosphorylation	TASQRRLSLEQAIEG HHHHHHHCHHHHHHH	28.22	29892262
289 (in isoform 2)	Phosphorylation	-	28.22	29892262

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of KGP25_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of KGP25_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of KGP25_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LOLA1_DROME	lola	physical	14605208
LOLA2_DROME	lola	physical	14605208
LOLA3_DROME	lola	physical	14605208
LOLA4_DROME	lola	physical	14605208
LOLA6_DROME	lola	physical	14605208
LOLA5_DROME	lola	physical	14605208
MERH_DROME	Mer	physical	14605208
HSP6A_DROME	Hsp67Ba	physical	14605208
RS3_DROME	RpS3	physical	14605208
GBLP_DROME	Rack1	physical	14605208
FOXO_DROME	foxo	genetic	22393355
LOLA1_DROME	lola	genetic	27098704
LOLA2_DROME	lola	genetic	27098704
LOLA3_DROME	lola	genetic	27098704
LOLA4_DROME	lola	genetic	27098704
LOLA6_DROME	lola	genetic	27098704
LOLA5_DROME	lola	genetic	27098704
LOLA1_DROME	lola	physical	27098704
LOLA2_DROME	lola	physical	27098704
LOLA3_DROME	lola	physical	27098704
LOLA4_DROME	lola	physical	27098704
LOLA6_DROME	lola	physical	27098704
LOLA5_DROME	lola	physical	27098704

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of KGP25_DROME

Related Literatures of Post-Translational Modification