| UniProt ID | SLIT_DROME | |
|---|---|---|
| UniProt AC | P24014 | |
| Protein Name | Protein slit | |
| Gene Name | sli | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 1504 | |
| Subcellular Localization | Secreted . | |
| Protein Description | A short-range repellent, controlling axon crossing of the midline and a long-range chemorepellent, controlling mesoderm migration and patterning away from the midline. May interact with extracellular matrix molecules. Repulsive ligand for the guidance receptor roundabout (robo) and prevents inappropriate midline crossing by Robo-expressing axons.. | |
| Protein Sequence | MAAPSRTTLMPPPFRLQLRLLILPILLLLRHDAVHAEPYSGGFGSSAVSSGGLGSVGIHIPGGGVGVITEARCPRVCSCTGLNVDCSHRGLTSVPRKISADVERLELQGNNLTVIYETDFQRLTKLRMLQLTDNQIHTIERNSFQDLVSLERLRLNNNRLKAIPENFVTSSASLLRLDISNNVITTVGRRVFKGAQSLRSLQLDNNQITCLDEHAFKGLVELEILTLNNNNLTSLPHNIFGGLGRLRALRLSDNPFACDCHLSWLSRFLRSATRLAPYTRCQSPSQLKGQNVADLHDQEFKCSGLTEHAPMECGAENSCPHPCRCADGIVDCREKSLTSVPVTLPDDTTELRLEQNFITELPPKSFSSFRRLRRIDLSNNNISRIAHDALSGLKQLTTLVLYGNKIKDLPSGVFKGLGSLQLLLLNANEISCIRKDAFRDLHSLSLLSLYDNNIQSLANGTFDAMKSIKTVHLAKNPFICDCNLRWLADYLHKNPIETSGARCESPKRMHRRRIESLREEKFKCSWDELRMKLSGECRMDSDCPAMCHCEGTTVDCTGRGLKEIPRDIPLHTTELLLNDNELGRISSDGLFGRLPHLVKLELKRNQLTGIEPNAFEGASHIQELQLGENKIKEISNKMFLGLHQLKTLNLYDNQISCVMPGSFEHLNSLTSLNLASNPFNCNCHLAWFAEWLRKKSLNGGAARCGAPSKVRDVQIKDLPHSEFKCSSENSEGCLGDGYCPPSCTCTGTVVRCSRNQLKEIPRGIPAETSELYLESNEIEQIHYERIRHLRSLTRLDLSNNQITILSNYTFANLTKLSTLIISYNKLQCLQRHALSGLNNLRVLSLHGNRISMLPEGSFEDLKSLTHIALGSNPLYCDCGLKWFSDWIKLDYVEPGIARCAEPEQMKDKLILSTPSSSFVCRGRVRNDILAKCNACFEQPCQNQAQCVALPQREYQCLCQPGYHGKHCEFMIDACYGNPCRNNATCTVLEEGRFSCQCAPGYTGARCETNIDDCLGEIKCQNNATCIDGVESYKCECQPGFSGEFCDTKIQFCSPEFNPCANGAKCMDHFTHYSCDCQAGFHGTNCTDNIDDCQNHMCQNGGTCVDGINDYQCRCPDDYTGKYCEGHNMISMMYPQTSPCQNHECKHGVCFQPNAQGSDYLCRCHPGYTGKWCEYLTSISFVHNNSFVELEPLRTRPEANVTIVFSSAEQNGILMYDGQDAHLAVELFNGRIRVSYDVGNHPVSTMYSFEMVADGKYHAVELLAIKKNFTLRVDRGLARSIINEGSNDYLKLTTPMFLGGLPVDPAQQAYKNWQIRNLTSFKGCMKEVWINHKLVDFGNAQRQQKITPGCALLEGEQQEEEDDEQDFMDETPHIKEEPVDPCLENKCRRGSRCVPNSNARDGYQCKCKHGQRGRYCDQGEGSTEPPTVTAASTCRKEQVREYYTENDCRSRQPLKYAKCVGGCGNQCCAAKIVRRRKVRMVCSNNRKYIKNLDIVRKCGCTKKCY | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 111 | N-linked_Glycosylation | RLELQGNNLTVIYET EEEECCCCEEEEEEC | 43.86 | - | |
| 231 | N-linked_Glycosylation | ILTLNNNNLTSLPHN EEEECCCCCCCCCCC | 46.98 | - | |
| 381 | N-linked_Glycosylation | RIDLSNNNISRIAHD EEECCCCCHHHHHHH | 37.55 | - | |
| 459 | N-linked_Glycosylation | NNIQSLANGTFDAMK CCHHHHHHCCHHHHH | 56.16 | - | |
| 807 | N-linked_Glycosylation | NQITILSNYTFANLT CEEEEEECCEECCHH | 36.10 | - | |
| 812 | N-linked_Glycosylation | LSNYTFANLTKLSTL EECCEECCHHHHHEH | 44.01 | - | |
| 982 | N-linked_Glycosylation | YGNPCRNNATCTVLE CCCCCCCCCEEEEEE | 19.78 | - | |
| 1022 | N-linked_Glycosylation | GEIKCQNNATCIDGV CCEEECCCCEEECCH | 15.67 | - | |
| 1084 | N-linked_Glycosylation | QAGFHGTNCTDNIDD CCCCCCCCCCCCHHH | 31.14 | - | |
| 1183 | N-linked_Glycosylation | TSISFVHNNSFVELE EEEEEECCCCCEEEE | 40.31 | - | |
| 1199 | N-linked_Glycosylation | LRTRPEANVTIVFSS CCCCCCCCEEEEECC | 29.78 | - | |
| 1267 | N-linked_Glycosylation | ELLAIKKNFTLRVDR EEEEECCCEEEEECH | 30.08 | - | |
| 1316 | N-linked_Glycosylation | YKNWQIRNLTSFKGC HHCCCCCCCCCCCCH | 49.66 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SLIT_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SLIT_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SLIT_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| JING_DROME | jing | genetic | 12015288 | |
| ELAV_DROME | elav | genetic | 17049509 | |
| ITA1_DROME | mew | genetic | 12040052 | |
| SCAL_DROME | sd | genetic | 20685961 | |
| ITA2_DROME | if | genetic | 12040052 | |
| SPTCB_DROME | beta-Spec | genetic | 17121810 | |
| SOS_DROME | Sos | genetic | 10751187 | |
| VG_DROME | vg | genetic | 20685961 | |
| ITA3_DROME | scb | genetic | 12040052 | |
| ITA3_DROME | scb | genetic | 16516189 | |
| SDC_DROME | Sdc | genetic | 14761655 | |
| EGFR_DROME | Egfr | genetic | 20685961 | |
| LAMA_DROME | LanA | genetic | 12040052 | |
| LAMA_DROME | LanA | genetic | 16516189 | |
| NRT_DROME | Nrt | genetic | 16516189 | |
| PKRA_DROME | kra | genetic | 17409115 | |
| RAS1_DROME | Ras85D | genetic | 16516189 | |
| ITBX_DROME | mys | genetic | 16516189 | |
| ABL_DROME | Abl | genetic | 12441051 | |
| ABL_DROME | Abl | genetic | 12973825 | |
| ABL_DROME | Abl | genetic | 23720041 | |
| DYN_DROME | shi | genetic | 15148300 | |
| SLIT_DROME | sli | physical | 15496984 | |
| SDC_DROME | Sdc | physical | 15043815 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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