| UniProt ID | EGFR_DROME | |
|---|---|---|
| UniProt AC | P04412 | |
| Protein Name | Epidermal growth factor receptor | |
| Gene Name | Egfr | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 1426 | |
| Subcellular Localization |
Membrane Single-pass type I membrane protein. |
|
| Protein Description | Binds to four ligands: Spitz, Gurken, Vein and Argos, which is an antagonist. Transduces the signal through the ras-raf-MAPK pathway. Involved in a myriad of developmental decisions. Critical for the proliferation of imaginal tissues, and for the determination of both the antero-posterior and dorso-ventral polarities of the oocyte. In the embryo, plays a role in the establishment of ventral cell fates, maintenance of amnioserosa and ventral neuroectodermal cells, germ band retraction, cell fate specification in the central nervous system and production of cuticle. Required for embryonic epithelial tissue repair.. | |
| Protein Sequence | MLLRRRNGPCPFPLLLLLLAHCICIWPASAARDRYARQNNRQRHQDIDRDRDRDRFLYRSSSAQNRQRGGANFALGLGANGVTIPTSLEDKNKNEFVKGKICIGTKSRLSVPSNKEHHYRNLRDRYTNCTYVDGNLKLTWLPNENLDLSFLDNIREVTGYILISHVDVKKVVFPKLQIIRGRTLFSLSVEEEKYALFVTYSKMYTLEIPDLRDVLNGQVGFHNNYNLCHMRTIQWSEIVSNGTDAYYNYDFTAPERECPKCHESCTHGCWGEGPKNCQKFSKLTCSPQCAGGRCYGPKPRECCHLFCAGGCTGPTQKDCIACKNFFDEAVSKEECPPMRKYNPTTYVLETNPEGKYAYGATCVKECPGHLLRDNGACVRSCPQDKMDKGGECVPCNGPCPKTCPGVTVLHAGNIDSFRNCTVIDGNIRILDQTFSGFQDVYANYTMGPRYIPLDPERREVFSTVKEITGYLNIEGTHPQFRNLSYFRNLETIHGRQLMESMFAALAIVKSSLYSLEMRNLKQISSGSVVIQHNRDLCYVSNIRWPAIQKEPEQKVWVNENLRADLCEKNGTICSDQCNEDGCWGAGTDQCLTCKNFNFNGTCIADCGYISNAYKFDNRTCKICHPECRTCNGAGADHCQECVHVRDGQHCVSECPKNKYNDRGVCRECHATCDGCTGPKDTIGIGACTTCNLAIINNDATVKRCLLKDDKCPDGYFWEYVHPQEQGSLKPLAGRAVCRKCHPLCELCTNYGYHEQVCSKCTHYKRREQCETECPADHYTDEEQRECFQRHPECNGCTGPGADDCKSCRNFKLFDANETGPYVNSTMFNCTSKCPLEMRHVNYQYTAIGPYCAASPPRSSKITANLDVNMIFIITGAVLVPTICILCVVTYICRQKQKAKKETVKMTMALSGCEDSEPLRPSNIGANLCKLRIVKDAELRKGGVLGMGAFGRVYKGVWVPEGENVKIPVAIKELLKSTGAESSEEFLREAYIMASEEHVNLLKLLAVCMSSQMMLITQLMPLGCLLDYVRNNRDKIGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAAGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARDPGRYLAIPGDKFTRLPAYTSQDEKDLIRKLAPTTDGSEAIAKPDDYLQPKAAPGPSHRTDCTDEMPKLNRYCKDPSNKNSSTGDDERDSSAREVGVGNLRLDLPVDEDDYLMPTCQPGPNNNNNMNNPNQNNMAAVGVAAGYMDLIGVPVSVDNPEYLLNAQTLGVGESPIPTQTIGIPVMGGPGTMEVKVPMPGSEPTSSDHEYYNDTQRELQPLHRNRNTETRV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 128 | N-linked_Glycosylation | NLRDRYTNCTYVDGN CHHHHCCCCEEECCC | 13.75 | - | |
| 241 | N-linked_Glycosylation | QWSEIVSNGTDAYYN EHHHHHCCCCEEECC | 46.63 | - | |
| 419 | N-linked_Glycosylation | GNIDSFRNCTVIDGN CCCCCCCCEEEEECC | 24.65 | - | |
| 443 | N-linked_Glycosylation | GFQDVYANYTMGPRY CCHHHHCCCCCCCCC | 18.34 | - | |
| 482 | N-linked_Glycosylation | GTHPQFRNLSYFRNL CCCHHHCCCHHHCCC | 34.33 | - | |
| 569 | N-linked_Glycosylation | RADLCEKNGTICSDQ HHHHHHHCCCCCCCC | 30.46 | - | |
| 599 | N-linked_Glycosylation | TCKNFNFNGTCIADC ECCCCCCCCEEEEEC | 46.07 | - | |
| 617 | N-linked_Glycosylation | SNAYKFDNRTCKICH CCEEECCCCCCCCCC | 44.27 | - | |
| 816 | N-linked_Glycosylation | NFKLFDANETGPYVN CCCCEECCCCCCCCC | 49.56 | - | |
| 823 | N-linked_Glycosylation | NETGPYVNSTMFNCT CCCCCCCCCCCEECC | 26.39 | - | |
| 828 | N-linked_Glycosylation | YVNSTMFNCTSKCPL CCCCCCEECCCCCCC | 19.82 | - | |
| 902 | Phosphorylation | KQKAKKETVKMTMAL HHHHCHHHHHHHHHH | 34.02 | - | |
| 1310 | Phosphorylation | LPVDEDDYLMPTCQP CCCCCCCCCCCCCCC | 19.74 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 902 | T | Phosphorylation | Kinase | PKC | - | Uniprot |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of EGFR_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of EGFR_DROME !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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