SOS_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SOS_DROME
• UniProt AC: P26675
• Protein Name: Protein son of sevenless
• Gene Name: Sos
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1596
• Protein Description: Promotes the exchange of Ras-bound GDP by GTP. Functions in signaling pathways initiated by the sevenless and epidermal growth factor receptor tyrosine kinases; implies a role for the ras pathway in neuronal development..
• Protein Sequence: MFSGPSGHAHTISYGGGIGLGTGGGGGSGGSGSGSQGGGGGIGIGGGGVAGLQDCDGYDFTKCENAARWRGLFTPSLKKVLEQVHPRVTAKEDALLYVEKLCLRLLAMLCAKPLPHSVQDVEEKVNKSFPAPIDQWALNEAKEVINSKKRKSVLPTEKVHTLLQKDVLQYKIDSSVSAFLVAVLEYISADILKMAGDYVIKIAHCEITKEDIEVVMNADRVLMDMLNQSEAHILPSPLSLPAQRASATYEETVKELIHDEKQYQRDLHMIIRVFREELVKIVSDPRELEPIFSNIMDIYEVTVTLLGSLEDVIEMSQEQSAPCVGSCFEELAEAEEFDVYKKYAYDVTSQASRDALNNLLSKPGASSLTTAGHGFRDAVKYYLPKLLLVPICHAFVYFDYIKHLKDLSSSQDDIESFEQVQGLLHPLHCDLEKVMASLSKERQVPVSGRVRRQLAIERTRELQMKVEHWEDKDVGQNCNEFIREDSLSKLGSGKRIWSERKVFLFDGLMVLCKANTKKQTPSAGATAYDYRLKEKYFMRRVDINDRPDSDDLKNSFELAPRMQPPIVLTAKNAQHKHDWMADLLMVITKSMLDRHLDSILQDIERKHPLRMPSPEIYKFAVPDSGDNIVLEERESAGVPMIKGATLCKLIERLTYHIYADPTFVRTFLTTYRYFCSPQQLLQLLVERFNIPDPSLVYQDTGTAGAGGMGGVGGDKEHKNSHREDWKRYRKEYVQPVQFRVLNVLRHWVDHHFYDFEKDPMLLEKLLNFLEHVNGKSMRKWVDSVLKIVQRKNEQEKSNKKIVYAYGHDPPPIEHHLSVPNDEITLLTLHPLELARQLTLLEFEMYKNVKPSELVGSPWTKKDKEVKSPNLLKIMKHTTNVTRWIEKSITEAENYEERLAIMQRAIEVMMVMLELNNFNGILSIVAAMGTASVYRLRWTFQGLPERYRKFLEECRELSDDHLKKYQERLRSINPPCVPFFGRYLTNILHLEEGNPDLLANTELINFSKRRKVAEIIGEIQQYQNQPYCLNEESTIRQFFEQLDPFNGLSDKQMSDYLYNESLRIEPRGCKTVPKFPRKWPHIPLKSPGIKPRRQNQTNSSSKLSNSTSSVAAAAAASSTATSIATASAPSLHASSIMDAPTAAAANAGSGTLAGEQSPQHNPHAFSVFAPVIIPERNTSSWSGTPQHTRTDQNNGEVSVPAPHLPKKPGAHVWANNNSTLASASAMDVVFSPALPEHLPPQSLPDSNPFASDTEAPPSPLPKLVVSPRHETGNRSPFHGRMQNSPTHSTASTVTLTGMSTSGGEEFCAGGFYFNSAHQGQPGAVPISPHVNVPMATNMEYRAVPPPLPPRRKERTESCADMAQKRQAPDAPTLPPRDGELSPPPIPPRLNHSTGISYLRQSHGKSKEFVGNSSLLLPNTSSIMIRRNSAIEKRAAATSQPNQAAAGPISTTLVTVSQAVATDEPLPLPISPAASSSTTTSPLTPAMSPMSPNIPSHPVESTSSSYAHQLRMRQQQQQQTHPAIYSQHHQHHATHLPHHPHQHHSNPTQSRSSPKEFFPIATSLEGTPKLPPKPSLSANFYNNPDKGTMFLYPSTNEE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
236	Phosphorylation	SEAHILPSPLSLPAQ CCCCCCCCCCCCCCH	34.72	21082442
1265	Phosphorylation	PLPKLVVSPRHETGN CCCCEEECCCCCCCC	14.56	22668510
1270	Phosphorylation	VVSPRHETGNRSPFH EECCCCCCCCCCCCC	33.36	21082442
1274	Phosphorylation	RHETGNRSPFHGRMQ CCCCCCCCCCCCCCC	35.60	21082442
1380	Phosphorylation	PPRDGELSPPPIPPR CCCCCCCCCCCCCCC	30.93	29892262
1391	Phosphorylation	IPPRLNHSTGISYLR CCCCCCCCCCHHHHH	27.53	21082442
1550	Phosphorylation	SNPTQSRSSPKEFFP CCCCCCCCCCHHHHC	57.13	19060867
1551	Phosphorylation	NPTQSRSSPKEFFPI CCCCCCCCCHHHHCC	38.59	22817900
1565	Phosphorylation	IATSLEGTPKLPPKP CCCCCCCCCCCCCCC	14.10	21082442
1573	Phosphorylation	PKLPPKPSLSANFYN CCCCCCCCCEECCCC	40.87	21082442

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SOS_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SOS_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SOS_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FEM1B_DROME	Fem-1	physical	14605208
DRK_DROME	drk	physical	9671493
7LESS_DROME	sev	genetic	7924981
VAV_DROME	Vav	genetic	20147552
CDC42_DROME	Cdc42	genetic	12453459
SRC42_DROME	Src42A	genetic	10075855
RHO1_DROME	Rho1	genetic	12453459
RAC1_DROME	Rac1	genetic	12453459
RS28_DROME	RpS28b	physical	22028469
SRC42_DROME	Src42A	physical	22028469
DRK_DROME	drk	physical	8462098
TITIN_DROME	sls	physical	22028469

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1550 AND SER-1551, ANDMASS SPECTROMETRY.
PubMed: 18327897