| UniProt ID | 7LESS_DROME | |
|---|---|---|
| UniProt AC | P13368 | |
| Protein Name | Protein sevenless | |
| Gene Name | sev | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 2554 | |
| Subcellular Localization |
Cell membrane Single-pass membrane protein . |
|
| Protein Description | Receptor for an extracellular signal required to instruct a cell to differentiate into an R7 photoreceptor. The ligand for sev is the boss (bride of sevenless) protein on the surface of the neighboring R8 cell.. | |
| Protein Sequence | MTMFWQQNVDHQSDEQDKQAKGAAPTKRLNISFNVKIAVNVNTKMTTTHINQQAPGTSSSSSNSQNASPSKIVVRQQSSSFDLRQQLARLGRQLASGQDGHGGISTILIINLLLLILLSICCDVCRSHNYTVHQSPEPVSKDQMRLLRPKLDSDVVEKVAIWHKHAAAAPPSIVEGIAISSRPQSTMAHHPDDRDRDRDPSEEQHGVDERMVLERVTRDCVQRCIVEEDLFLDEFGIQCEKADNGEKCYKTRCTKGCAQWYRALKELESCQEACLSLQFYPYDMPCIGACEMAQRDYWHLQRLAISHLVERTQPQLERAPRADGQSTPLTIRWAMHFPEHYLASRPFNIQYQFVDHHGEELDLEQEDQDASGETGSSAWFNLADYDCDEYYVCEILEALIPYTQYRFRFELPFGENRDEVLYSPATPAYQTPPEGAPISAPVIEHLMGLDDSHLAVHWHPGRFTNGPIEGYRLRLSSSEGNATSEQLVPAGRGSYIFSQLQAGTNYTLALSMINKQGEGPVAKGFVQTHSARNEKPAKDLTESVLLVGRRAVMWQSLEPAGENSMIYQSQEELADIAWSKREQQLWLLNVHGELRSLKFESGQMVSPAQQLKLDLGNISSGRWVPRRLSFDWLHHRLYFAMESPERNQSSFQIISTDLLGESAQKVGESFDLPVEQLEVDALNGWIFWRNEESLWRQDLHGRMIHRLLRIRQPGWFLVQPQHFIIHLMLPQEGKFLEISYDGGFKHPLPLPPPSNGAGNGPASSHWQSFALLGRSLLLPDSGQLILVEQQGQAASPSASWPLKNLPDCWAVILLVPESQPLTSAGGKPHSLKALLGAQAAKISWKEPERNPYQSADAARSWSYELEVLDVASQSAFSIRNIRGPIFGLQRLQPDNLYQLRVRAINVDGEPGEWTEPLAARTWPLGPHRLRWASRQGSVIHTNELGEGLEVQQEQLERLPGPMTMVNESVGYYVTGDGLLHCINLVHSQWGCPISEPLQHVGSVTYDWRGGRVYWTDLARNCVVRMDPWSGSRELLPVFEANFLALDPRQGHLYYATSSQLSRHGSTPDEAVTYYRVNGLEGSIASFVLDTQQDQLFWLVKGSGALRLYRAPLTAGGDSLQMIQQIKGVFQAVPDSLQLLRPLGALLWLERSGRRARLVRLAAPLDVMELPTPDQASPASALQLLDPQPLPPRDEGVIPMTVLPDSVRLDDGHWDDFHVRWQPSTSGGNHSVSYRLLLEFGQRLQTLDLSTPFARLTQLPQAQLQLKISITPRTAWRSGDTTRVQLTTPPVAPSQPRRLRVFVERLATALQEANVSAVLRWDAPEQGQEAPMQALEYHISCWVGSELHEELRLNQSALEARVEHLQPDQTYHFQVEARVAATGAAAGAASHALHVAPEVQAVPRVLYANAEFIGELDLDTRNRRRLVHTASPVEHLVGIEGEQRLLWVNEHVELLTHVPGSAPAKLARMRAEVLALAVDWIQRIVYWAELDATAPQAAIIYRLDLCNFEGKILQGERVWSTPRGRLLKDLVALPQAQSLIWLEYEQGSPRNGSLRGRNLTDGSELEWATVQPLIRLHAGSLEPGSETLNLVDNQGKLCVYDVARQLCTASALRAQLNLLGEDSIAGQLAQDSGYLYAVKNWSIRAYGRRRQQLEYTVELEPEEVRLLQAHNYQAYPPKNCLLLPSSGGSLLKATDCEEQRCLLNLPMITASEDCPLPIPGVRYQLNLTLARGPGSEEHDHGVEPLGQWLLGAGESLNLTDLLPFTRYRVSGILSSFYQKKLALPTLVLAPLELLTASATPSPPRNFSVRVLSPRELEVSWLPPEQLRSESVYYTLHWQQELDGENVQDRREWEAHERRLETAGTHRLTGIKPGSGYSLWVQAHATPTKSNSSERLHVRSFAELPELQLLELGPYSLSLTWAGTPDPLGSLQLECRSSAEQLRRNVAGNHTKMVVEPLQPRTRYQCRLLLGYAATPGAPLYHGTAEVYETLGDAPSQPGKPQLEHIAEEVFRVTWTAARGNGAPIALYNLEALQARSDIRRRRRRRRRNSGGSLEQLPWAEEPVVVEDQWLDFCNTTELSCIVKSLHSSRLLLFRVRARSLEHGWGPYSEESERVAEPFVSPEKRGSLVLAIIAPAAIVSSCVLALVLVRKVQKRRLRAKKLLQQSRPSIWSNLSTLQTQQQLMAVRNRAFSTTLSDADIALLPQINWSQLKLLRFLGSGAFGEVYEGQLKTEDSEEPQRVAIKSLRKGASEFAELLQEAQLMSNFKHENIVCLVGICFDTESISLIMEHMEAGDLLSYLRAARATSTQEPQPTAGLSLSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDIYKSDYYRKEGEGLLPVRWMSPESLVDGLFTTQSDVWAFGVLCWEILTLGQQPYAARNNFEVLAHVKEGGRLQQPPMCTEKLYSLLLLCWRTDPWERPSFRRCYNTLHAISTDLRRTQMASATADTVVSCSRPEFKVRFDGQPLEEHREHNERPEDENLTLREVPLKDKQLYANEGVSRL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 30 | N-linked_Glycosylation | AAPTKRLNISFNVKI CCCCCEEEEEEEEEE | 31.71 | - | |
| 129 | N-linked_Glycosylation | CDVCRSHNYTVHQSP HHHHHHCCCCCCCCC | 35.10 | - | |
| 481 | N-linked_Glycosylation | RLSSSEGNATSEQLV EEECCCCCCCCCCEE | 35.67 | - | |
| 505 | N-linked_Glycosylation | SQLQAGTNYTLALSM EECCCCCCEEEEEHH | 27.20 | - | |
| 617 | N-linked_Glycosylation | QLKLDLGNISSGRWV HEEECCCCCCCCCCC | 37.96 | - | |
| 647 | N-linked_Glycosylation | AMESPERNQSSFQII HHCCCCCCCCCEEEE | 44.41 | - | |
| 966 | N-linked_Glycosylation | PGPMTMVNESVGYYV CCCCEECCCCCCEEE | 25.63 | - | |
| 1228 | N-linked_Glycosylation | QPSTSGGNHSVSYRL ECCCCCCCCCEEEEH | 27.99 | - | |
| 1313 | N-linked_Glycosylation | ATALQEANVSAVLRW HHHHHHCCCCEEEEC | 27.76 | - | |
| 1353 | N-linked_Glycosylation | LHEELRLNQSALEAR HHHHHHCCHHHHHHH | 27.59 | - | |
| 1550 | N-linked_Glycosylation | YEQGSPRNGSLRGRN ECCCCCCCCCCCCCC | 48.03 | - | |
| 1557 | N-linked_Glycosylation | NGSLRGRNLTDGSEL CCCCCCCCCCCCCCE | 50.55 | - | |
| 1639 | N-linked_Glycosylation | GYLYAVKNWSIRAYG CCEEEEEEEEEEEEC | 31.00 | - | |
| 1725 | N-linked_Glycosylation | PGVRYQLNLTLARGP CCCEEEEEEEEECCC | 18.56 | - | |
| 1756 | N-linked_Glycosylation | LGAGESLNLTDLLPF CCCCCCCCHHHHCCC | 50.61 | - | |
| 1804 | N-linked_Glycosylation | ATPSPPRNFSVRVLS CCCCCCCCEEEEEEC | 39.04 | - | |
| 1811 | Phosphorylation | NFSVRVLSPRELEVS CEEEEEECCCEEEEE | 21.03 | 22668510 | |
| 1889 | N-linked_Glycosylation | HATPTKSNSSERLHV EECCCCCCCCCCEEE | 51.62 | - | |
| 1947 | N-linked_Glycosylation | LRRNVAGNHTKMVVE HHHHHCCCCCEEEEC | 29.89 | - | |
| 2073 | N-linked_Glycosylation | DQWLDFCNTTELSCI CEEECCCCHHHHHHH | 50.45 | - | |
| 2380 | Phosphorylation | RDIYKSDYYRKEGEG HHHHHCCCCCCCCCC | 16.56 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of 7LESS_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of 7LESS_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of 7LESS_DROME !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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