DAB_DROME - dbPTM
DAB_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DAB_DROME
UniProt AC P98081
Protein Name Protein disabled
Gene Name Dab
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 2224
Subcellular Localization Cytoplasm .
Protein Description Together with Abl, involved in embryonic neural development. May have a role in eye development. Acts as an adapter protein for SH2-domain containing proteins during sevenless (sev) signaling..
Protein Sequence MVKSLVAKLSTASSNLSLASTFGGGSGAAEETNYAKHRNDPGRFFGDGVQFKAKLIGILEVGEARGDRMCQEALQDLKMAIRAAGEHKQRITIHVTIDGLRLRDEKTGDSLYHHPVHKISFIAQDMTDSRAFGYIFGSPDSGHRFFGIKTDKAASQVVLAMRDLFQVVFELKKKEIEMARQQIQGKSLHDHSSQLASLSSLKSSGLGGMGLGHSDLASGGISSGHALTLLGSSLSTTNGTSRLGVSLDVAKASGSAAKEVSPESVADLVDLEQELTSLQRGISQMERITPNEPTTSSTGGAGHPSLAKSASEDDPFGDSFIYVPSYSILPPPPDSGRNRHKPPNKTPDAVTSLDAMLSPPPGTSSSHGSASAGLQAADNDDDNWLQELDQQNDVFDTSKVVSSSGLGSVLAMAPLASSESTATPTQQLTEVAAGSGPLADLDIGLSTALGNEEQTSTILSLDAFTDLDPLGTGRTRPYVDKKYFFQELKNPPKKLLKELSSGSQAGLGLGLSLGQLDGLFPEDSTTISTTTTTATNITAGNPQQNSANTLTSTASTAASLGQLLSTVALNPDPLPAPISIPTSISHSITPSAELKLLLGHVTNPPNPTGHYYTTEPPTLNSLENPHPPADPVLLPRDTDPFSPTRKKSDPDPFQESDLFAKLDAFEFEAPPAVPAPSIPNLATETKANVFNGPLQVQLPPEKELQLQQPPSTVRNRPTASVSALPSGGALDVISSISNKKMPHLFGQARSFGKSGSDIGSSVNMRRLQESDSLSETEAAPEPPPRPDSTPYSEPPPLPPKKQFSDLVIRPSPANTTQPPTSGRYEYLNSNVTARRTASSVDAPPIPLPSRRVGRSDGCFPGPGRPRKPGHTEDDYLAPLGAPPPLLPPPSQGSSARARPQRQASLGRPQDIYENKAEILQAQAQAQAQAPEVAPSSNTLAPDITLTQLLTLGMDDLAIKLNVPASKLSTMTLVQLTAYLSEYLSSEKSQVHSQERRSSPANTAPAPASTAAVFKVNFDQQTSFVAKFDDTFGEDEPVMPSGSSDSTFVANFANFNDAPTPVPTVSPVVATVPSADRYAVFREIIDQELQQQQQETDLMGDLTPPPVDETQAKEISEGLEVNNVGAELPIDALDVKPAPKIDTKITEVVAQAKDRYAALRDIILVENLFDKPAIATDTQPEKEKDLLQDFPEFSDEFNEDHDLRQIMDHQNVQTHARDRHGLVDSRGFPTEPSSSALTVGDYDEDEDADAGGESSLDSNEKDAEPVSGQDQYEKLSTSTQQLDAAAPALEDVQQLQQQSLPPKQDQKFLSILTAPGGGTKDDIEIDELMHRAISNLSLDSRDRVSPATSSAAPSRGAPGLHTPSQFNDVSTSPIPLQKPGMGPSPVPSQLSAVSQLIDTATKQMMGDKDREKQSWATFDSPKAKGKARLTLPPPPPPASNTSQPDTVESPCSSDPRDDGWSKQQRRWAKKERQQTSSSSRDLSPWDDETPEYLKRRQLAAAQMAHPHQPPMQAPPQHTDRHGYYMRHARRMNSCDEDYDYDGEFVARRDQPQHQQQQRKFKHGLSRSRDNFELESPSWYHHPAHHTWSPQEIEQVRVRSFDRTAYERSSYGPPPPIYDKRGQLRGKYRGDHRDRERERDRDREYRDYARPSYDFDYENVYEERGGRSPLAYKPGRGGGDYLYDRERDRDRERDRKSFDRESLESYESATRRRRSFGSGNDVYGSLDSRDDYRGDRERDRERDREQMKTRSLRKPTTTSGKLRISGDIDYEQDSEQDFQQRSGVRSLQRPNQLGGDVVLPSNAVVGPQRLRKSSGSSPWDGEEPALPGQKSWKRPASAAETERRLAESRRAVALGQTPSDGEKERRFRKKTRARSAKDLATVGAPSASTSAPSRSSYGRGIRDNYDYICPGQRNDDDDDDDEDYVDDEPPTDEDKFERLNRRRHEMHQRMLESERRQMERHQPPSLAKLPGQNRTRGVVANSDYGFVDSYEQTPTPTPRSNASSTGPGGLMMSGGESSAGVTSSKFNFDDGFESDFNQSSPPPAPAGTASSCNSTPAGPVSANANNGGSKSLFRFSNDFSDREKREQFEMDTPPTSTPPITQKLRFDDNVKVSQFDDAAFEDDFAKASFDFEKEQAGSATAGAGGSGAMSRKQNMRTSKLQQRQELIKKSESVNIFAKKQEDPFEDDEFFKSPDQEQAMDQHNDDTEGGKFQWSEDANFAKFDENM
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
112PhosphorylationEKTGDSLYHHPVHKI
CCCCCCCCCCCCHHE		11.319671493
483PhosphorylationRPYVDKKYFFQELKN
CCCCCHHHHHHHHCC		18.509671493
648PhosphorylationFSPTRKKSDPDPFQE
CCCCCCCCCCCCCCC		58.3619429919
836PhosphorylationSNVTARRTASSVDAP
CCCCEECCCCCCCCC		25.9021082442
839PhosphorylationTARRTASSVDAPPIP
CEECCCCCCCCCCCC		22.8821082442
904PhosphorylationARPQRQASLGRPQDI
CCHHHHHHCCCCHHH		24.0221082442
997PhosphorylationVHSQERRSSPANTAP
HCCCCCCCCCCCCCC		47.0623607784
998PhosphorylationHSQERRSSPANTAPA
CCCCCCCCCCCCCCC		33.9723607784
1102PhosphorylationTDLMGDLTPPPVDET
CCCCCCCCCCCCCHH		38.1922668510
1193PhosphorylationLQDFPEFSDEFNEDH
HHHCHHHHHHCCCCC		34.2719429919
1224PhosphorylationDRHGLVDSRGFPTEP
HCCCCCCCCCCCCCC		27.1619429919
1266PhosphorylationEKDAEPVSGQDQYEK
CCCCCCCCCHHHHHH		41.2627794539
1333PhosphorylationELMHRAISNLSLDSR
HHHHHHHHCCCCCCC		30.6319429919
1336PhosphorylationHRAISNLSLDSRDRV
HHHHHCCCCCCCCCC		34.0919429919
1339PhosphorylationISNLSLDSRDRVSPA
HHCCCCCCCCCCCCC		41.1819429919
1344PhosphorylationLDSRDRVSPATSSAA
CCCCCCCCCCCCCCC		15.0919429919
1348PhosphorylationDRVSPATSSAAPSRG
CCCCCCCCCCCCCCC		21.7822817900
1349PhosphorylationRVSPATSSAAPSRGA
CCCCCCCCCCCCCCC		24.8922817900
1419PhosphorylationQSWATFDSPKAKGKA
CCCCCCCCCCCCCCC		24.9027626673
1482PhosphorylationSSSSRDLSPWDDETP
CCCCCCCCCCCCCCH		28.3819429919
1604PhosphorylationRSFDRTAYERSSYGP
ECCCCCCHHHHCCCC		15.979671493
1609PhosphorylationTAYERSSYGPPPPIY
CCHHHHCCCCCCCCC		34.599671493
1643PhosphorylationERDRDREYRDYARPS
HHHHCHHHHHHCCCC		15.079671493
1646PhosphorylationRDREYRDYARPSYDF
HCHHHHHHCCCCCCC		8.779671493
1655PhosphorylationRPSYDFDYENVYEER
CCCCCCCHHHCCHHC		14.929671493
1666PhosphorylationYEERGGRSPLAYKPG
CHHCCCCCCCCCCCC		27.7819429919
1681PhosphorylationRGGGDYLYDRERDRD
CCCCCCCCCCCHHCC		13.519671493
1700PhosphorylationRKSFDRESLESYESA
HHHCCHHHHHHHHHH		38.0322817900
1713PhosphorylationSATRRRRSFGSGNDV
HHHHHHHCCCCCCCC		31.9519429919
1716PhosphorylationRRRRSFGSGNDVYGS
HHHHCCCCCCCCCCC		32.2019429919
1768PhosphorylationRISGDIDYEQDSEQD
EEECCCCCCCCCHHH		18.809671493
1784PhosphorylationQQRSGVRSLQRPNQL
HHHHCCHHCCCCCCC		26.8421082442
1811PhosphorylationGPQRLRKSSGSSPWD
CHHHHHCCCCCCCCC		33.2319429919
1812PhosphorylationPQRLRKSSGSSPWDG
HHHHHCCCCCCCCCC		45.8119429919
1814PhosphorylationRLRKSSGSSPWDGEE
HHHCCCCCCCCCCCC		34.8619429919
1815PhosphorylationLRKSSGSSPWDGEEP
HHCCCCCCCCCCCCC		33.2719429919
1835PhosphorylationKSWKRPASAAETERR
CCCCCCCCHHHHHHH		30.6021082442
1857PhosphorylationVALGQTPSDGEKERR
HHCCCCCCCHHHHHH		62.7319429919
1903PhosphorylationGRGIRDNYDYICPGQ
CCCCCCCCCEECCCC		17.8927626673
1905PhosphorylationGIRDNYDYICPGQRN
CCCCCCCEECCCCCC		8.289671493
2074PhosphorylationSKSLFRFSNDFSDRE
CCHHEEECCCCCHHH		31.1019429919
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
112YPhosphorylationKinaseABLP00522
Uniprot
483YPhosphorylationKinaseABLP00522
Uniprot
1604YPhosphorylationKinaseABLP00522
Uniprot
1609YPhosphorylationKinaseABLP00522
Uniprot
1643YPhosphorylationKinaseABLP00522
Uniprot
1646YPhosphorylationKinaseABLP00522
Uniprot
1655YPhosphorylationKinaseABLP00522
Uniprot
1681YPhosphorylationKinaseABLP00522
Uniprot
1768YPhosphorylationKinaseABLP00522
Uniprot
1905YPhosphorylationKinaseABLP00522
Uniprot
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DAB_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DAB_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DRK_DROMEdrkphysical
9671493
7LESS_DROMEsevphysical
9671493
ENA_DROMEenagenetic
20940230
ABL_DROMEAblgenetic
20940230
NOTCH_DROMENphysical
15123610
NOTCH_DROMENphysical
18062953
NOTCH_DROMENphysical
9581760
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DAB_DROME

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-998; SER-1336; SER-1339;SER-1344; SER-1348; SER-1700; SER-1713; SER-1716; SER-1811; SER-1812;SER-1814; SER-1815 AND SER-2074, AND MASS SPECTROMETRY.

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