FOSLA_DROME - dbPTM
FOSLA_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FOSLA_DROME
UniProt AC P21525
Protein Name Transcription factor kayak, isoforms A/B/F
Gene Name kay
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 755
Subcellular Localization Nucleus .
Protein Description Developmentally regulated transcription factor AP-1 binds and recognizes the enhancer DNA sequence: 5'-TGA[CG]TCA-3'. May play a role in the function or determination of a particular subset of cells in the developing embryo. It is able to carry out its function either independently of or in conjunction with Jra..
Protein Sequence MKNLNGRTHNACYHPYYHQSLHFAQQQQQQQQHHLQQQQQHMQQQQQQQQAPQQQLRHQQRQLPTQPAYQQSQSVAHNAFPLRSSSNNYGHVASSAYAASSGSHNSNNAAAMAAVCQMQNFFNQQQQQQQQLEFNNNCMPINYYQQQQQQHYPSESQSSASGWNPETPGQAQLALTATTCNTTAAATCNTTAAATTSTTATSAAAGSDNNHSDNFAMDASEIATFLANELFLQQLGNFETGQSVLTLTTPTLTPTTTRNIEDTLGHLLSDTQTDRVAGCAGFAVPKVLPNAIDVLGMGIPTGVSSLPLQQTFDLSLGQGSESEDSNASYNDTQMNEEQDTTDTSSAHTDSTSYQAGHIMAGSVNGGGVNNFSNVLAAVSSSRGSASVGSSNANTSNTPARRGGGRRPNRSTNMTPEEEQKRAVRRERNKQAAARCRKRRVDQTNELTEEVEQLEKRGESMRKEIEVLTNSKNQLEYLLATHRATCQKIRSDMLSVVTCNGLIAPAGLLSAGSSGSGASSHHNHNSNDSSNGTITGMDATLNSTGRSNSPLDLKPAANIDSLLMHIKDEPLDGAIDSGSSLDQDGPPPSKRITLPPMSTMPHVHLSTILTPTGASSGSLQTPITSTAPGGFGSAFPVTSNGSSINNINSIGNNMNSPTLNAHNKVPKERPNTLAFQRPLGQMHLTMANNKAGGPTQIQGVPIQTPSTGTFNFDSLMDGGTGLTPVSGPLVPNSSSTNKHPLELPTPTAEPSKLVSL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
39 (in isoform 3)Phosphorylation-30.7019429919
40 (in isoform 3)Phosphorylation-29.6719429919
42 (in isoform 3)Phosphorylation-3.1519429919
44 (in isoform 3)Phosphorylation-35.1619429919
46 (in isoform 3)Phosphorylation-38.4219429919
47 (in isoform 3)Phosphorylation-38.4219429919
48 (in isoform 3)Phosphorylation-32.7719429919
269PhosphorylationDTLGHLLSDTQTDRV
HHHHHHCCCCCCHHH		45.0019429919
271PhosphorylationLGHLLSDTQTDRVAG
HHHHCCCCCCHHHCC		29.9619429919
515PhosphorylationLSAGSSGSGASSHHN
HCCCCCCCCCCCCCC		32.8918327897
546PhosphorylationTLNSTGRSNSPLDLK
EECCCCCCCCCCCCC		42.9019429919
548PhosphorylationNSTGRSNSPLDLKPA
CCCCCCCCCCCCCCC		28.252116361
576PhosphorylationPLDGAIDSGSSLDQD
CCCCCCCCCCCCCCC		34.1719429919
578PhosphorylationDGAIDSGSSLDQDGP
CCCCCCCCCCCCCCC		31.5119429919
579PhosphorylationGAIDSGSSLDQDGPP
CCCCCCCCCCCCCCC		39.2219429919
744PhosphorylationKHPLELPTPTAEPSK
CCCCCCCCCCCCHHH		45.9919429919
746PhosphorylationPLELPTPTAEPSKLV
CCCCCCCCCCHHHCC		46.2421082442
751AcetylationTPTAEPSKLVSL---
CCCCCHHHCCCC---		64.7221791702
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FOSLA_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FOSLA_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FOSLA_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
JRA_DROMEJraphysical
14605208
JRA_DROMEJraphysical
23661758
SGG_DROMEsgggenetic
18832361
PIGE_DROMEpigeongenetic
18832361
JING_DROMEjinggenetic
16648585
LBM_DROMElbmgenetic
18832361
JRA_DROMEJragenetic
9381174
JRA_DROMEJragenetic
18832361
SEM2A_DROMESema-2agenetic
18832361
SDC_DROMESdcgenetic
18832361
SPY_DROMEstygenetic
18832361
BICRD_DROMECG32137genetic
16648585
CPD1_DROMED1genetic
16648585
7UP1_DROMEsvpgenetic
12049770
7UP2_DROMEsvpgenetic
12049770
ATX2_DROMEAtx2genetic
16648585
ATRX_DROMEXNPgenetic
16648585
JNK_DROMEbskgenetic
9381174
HDAC1_DROMERpd3physical
16391236
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FOSLA_DROME

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-548, AND MASSSPECTROMETRY.

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