HDAC1_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HDAC1_DROME
• UniProt AC: Q94517
• Protein Name: Histone deacetylase Rpd3
• Gene Name: Rpd3
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 521
• Subcellular Localization: Nucleus .
• Protein Description: Catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). [PubMed: 11571273]
• Protein Sequence: MQSHSKKRVCYYYDSDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATADEMTKFHSDEYVRFLRSIRPDNMSEYNKQMQRFNVGEDCPVFDGLYEFCQLSAGGSVAAAVKLNKQASEICINWGGGLHHAKKSEASGFCYVNDIVLGILELLKYHQRVLYIDIDVHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNIPLRDGMDDDAYESIFVPIISKVMETFQPAAVVLQCGADSLTGDRLGCFNLTVKGHGKCVEFVKKYNLPFLMVGGGGYTIRNVSRCWTYETSVALAVEIANELPYNDYFEYFGPDFKLHISPSNMTNQNTSEYLEKIKNRLFENLRMLPHAPGVQIQAIPEDAINDESDDEDKVDKDDRLPQSDKDKRIVPENEYSDSEDEGEGGRRDNRSYKGQRKRPRLDKDTNSNKASSETSSEIKDEKEKGDGADGEESTASNTNSNNNSNNKSDNDAGATANAGSGSGSGSGAGAKGAKENNI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
87	Ubiquitination	DNMSEYNKQMQRFNV CCHHHHHHHHHHCCC	46.36	31113955
391	Phosphorylation	EDAINDESDDEDKVD HHHCCCCCCCCCCCC	53.90	21082442
406	Phosphorylation	KDDRLPQSDKDKRIV CCCCCCCCHHCCCCC	44.69	19429919
418	Phosphorylation	RIVPENEYSDSEDEG CCCCCCCCCCCCCCC	29.38	19429919
419	Phosphorylation	IVPENEYSDSEDEGE CCCCCCCCCCCCCCC	28.60	21082442
421	Phosphorylation	PENEYSDSEDEGEGG CCCCCCCCCCCCCCC	40.79	21082442
448	Phosphorylation	RPRLDKDTNSNKASS CCCCCCCCCCCCCCC	46.41	29892262
450	Phosphorylation	RLDKDTNSNKASSET CCCCCCCCCCCCCCC	41.63	29892262
454	Phosphorylation	DTNSNKASSETSSEI CCCCCCCCCCCHHHH	30.25	19429919
455	Phosphorylation	TNSNKASSETSSEIK CCCCCCCCCCHHHHH	50.15	19429919
457	Phosphorylation	SNKASSETSSEIKDE CCCCCCCCHHHHHHH	39.23	19429919
458	Phosphorylation	NKASSETSSEIKDEK CCCCCCCHHHHHHHH	23.17	29892262
462	Acetylation	SETSSEIKDEKEKGD CCCHHHHHHHHHCCC	56.64	21791702
491	Phosphorylation	NNNSNNKSDNDAGAT CCCCCCCCCCCCCCC	43.71	19429919
507	Phosphorylation	NAGSGSGSGSGAGAK CCCCCCCCCCCCCCC	31.33	27794539

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HDAC1_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HDAC1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HDAC1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PCL_DROME	Pcl	physical	12697833
EZ_DROME	E(z)	physical	12697833
EZ_DROME	E(z)	physical	11124122
ESC_DROME	esc	physical	11124122
PC_DROME	Pc	physical	11493709
CAF1_DROME	Caf1	physical	15516265
RBF_DROME	Rbf	physical	15456884
AN32A_DROME	Mapmodulin	physical	22036573
AGT2L_DROME	CG8745	physical	22036573
SIR2_DROME	Sir2	genetic	15520384
PROS_DROME	pros	genetic	20660276
RCOR_DROME	CoRest	physical	22036573
ESC_DROME	esc	physical	11581156
ESC_DROME	esc	physical	12697833
ESC_DROME	esc	physical	12408863
FOSLD_DROME	kay	physical	16391236
FOSLA_DROME	kay	physical	16391236
EZ_DROME	E(z)	physical	12408863
PC_DROME	Pc	physical	11581156
CAF1_DROME	Caf1	physical	11124122
CAF1_DROME	Caf1	physical	12697833
GROU_DROME	gro	physical	10485845
SUZ12_DROME	Su(z)12	physical	12408863

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-391; SER-419; SER-421;SER-455 AND THR-457, AND MASS SPECTROMETRY.
PubMed: 18327897