dbPTM

RCOR_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RCOR_DROME
UniProt AC	Q59E36
Protein Name	REST corepressor
Gene Name	CoRest
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	590
Subcellular Localization	Nucleus .
Protein Description	Essential component of a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited by Ttk88 and probably acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. May serve as a molecular beacon for the recruitment of molecular machinery that imposes silencing across a chromosomal interval..
Protein Sequence	MVLAERNTTDVVRNGRRSRGPSPNTHTTGGVTNSASLVGSGNNSGHSGNANANEKTTTAVPGAGTPESSDDDNSTKRNGKSKAKQSEYEEKIRVGRDYQAVCPPLVPEAERRPEQMNERALLVWSPTKEIPDLKLEEYISVAKEKYGYNGEQALGMLFWHKHDLERAVMDLANFTPFPDEWTIEDKVLFEQAFQFHGKSFHRIRQMLPDKSIASLVKYYYSWKKTRHRSSAMDRQEKAIKAVVKDGSENGSEVGSNEESDNDDKIQKNRQVMEQLDKECETINVDDVLSKPAAANTESAQPRISARWLPDEIQVALLAIREYGKNFPTIAKVVATKTEAHVRTFYLNNRRRYNLDQIVKEYEAGKSEESGAEEQTEPAVDAAAAGAATASAPSAADSTSAASATADRKQSTENSNNGVETMQESLPKKEDPKKPELAAAVLKIGVAEAADAVATVASSTASGVIGAATSASKPSTSATITIIDESDTATNSSSDVVTTGLATSTGSSALSSTTSAPASKTQTSSEELSAQKSNPASGIAAIGAATGGGQTANSSGSKRDSSVLPVAEQPPAKKIALSTGGGSSVAEFLAN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	VVRNGRRSRGPSPNT HHHCCCCCCCCCCCC	39.98	19429919
22	Phosphorylation	GRRSRGPSPNTHTTG CCCCCCCCCCCCCCC	33.34	19429919
25	Phosphorylation	SRGPSPNTHTTGGVT CCCCCCCCCCCCCCC	24.80	19429919
27	Phosphorylation	GPSPNTHTTGGVTNS CCCCCCCCCCCCCCC	25.71	19429919
28	Phosphorylation	PSPNTHTTGGVTNSA CCCCCCCCCCCCCCC	25.08	19429919
32	Phosphorylation	THTTGGVTNSASLVG CCCCCCCCCCCEECC	27.08	19429919
34	Phosphorylation	TTGGVTNSASLVGSG CCCCCCCCCEECCCC	15.18	23607784
36	Phosphorylation	GGVTNSASLVGSGNN CCCCCCCEECCCCCC	24.33	23607784
65	Phosphorylation	TAVPGAGTPESSDDD CCCCCCCCCCCCCCC	24.29	19429919
68	Phosphorylation	PGAGTPESSDDDNST CCCCCCCCCCCCCCC	40.03	19429919
69	Phosphorylation	GAGTPESSDDDNSTK CCCCCCCCCCCCCCC	43.31	19429919
74	Phosphorylation	ESSDDDNSTKRNGKS CCCCCCCCCCCCCCH	42.15	19429919
75	Phosphorylation	SSDDDNSTKRNGKSK CCCCCCCCCCCCCHH	40.03	19429919
125	Phosphorylation	ERALLVWSPTKEIPD CCEEEEECCCCCCCC	18.40	21082442
255	Phosphorylation	ENGSEVGSNEESDND CCCCCCCCCCCCCCH	46.36	29892262
259	Phosphorylation	EVGSNEESDNDDKIQ CCCCCCCCCCHHHHH	35.22	29892262
375	Phosphorylation	ESGAEEQTEPAVDAA CCCCHHCCHHHHHHH	2.97	18327897
410	Phosphorylation	ATADRKQSTENSNNG HCCCHHHHCCCCCCH	18.62	19429919
411	Phosphorylation	TADRKQSTENSNNGV CCCHHHHCCCCCCHH	4.59	19429919
414	Phosphorylation	RKQSTENSNNGVETM HHHHCCCCCCHHHHH	28.69	19429919
442	Phosphorylation	ELAAAVLKIGVAEAA HHHHHHHHHHHHHHH	47.41	18327897
478	Phosphorylation	SKPSTSATITIIDES CCCCCCEEEEEECCC	36.37	18327897
481	Phosphorylation	STSATITIIDESDTA CCCEEEEEECCCCCC	25.99	18327897
560	Phosphorylation	SSGSKRDSSVLPVAE CCCCCCCCCCCCCCC	33.96	19429919
561	Phosphorylation	SGSKRDSSVLPVAEQ CCCCCCCCCCCCCCC	40.63	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RCOR_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RCOR_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RCOR_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RCOR_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18; SER-22; THR-25;THR-65; SER-68; SER-69; THR-442; THR-478 AND SER-481, AND MASSSPECTROMETRY.	18327897 [Abstract]
"An integrated chemical, mass spectrometric and computational strategyfor (quantitative) phosphoproteomics: application to Drosophilamelanogaster Kc167 cells."; Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D.,Juenger M.A., Eng J.K., Aebersold R., Tao W.A.; Mol. Biosyst. 3:275-286(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22; SER-34; SER-36 ANDSER-627, AND MASS SPECTROMETRY.	17372656 [Abstract]