dbPTM

EZ_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	EZ_DROME
UniProt AC	P42124
Protein Name	Histone-lysine N-methyltransferase E(z)
Gene Name	E(z)
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	760
Subcellular Localization	Nucleus .
Protein Description	Polycomb group (PcG) protein. Catalytic subunit of the Esc/E(z) complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. While PcG proteins are generally required to maintain the transcriptionally repressive state of homeotic genes throughout development, this protein is specifically required during the first 6 hours of embryogenesis to establish the repressed state. The Esc/E(z) complex is necessary but not sufficient for the repression of homeotic target genes, suggesting that the recruitment of the distinct PRC1 complex is also required..
Protein Sequence	MNSTKVPPEWKRRVKSEYIKIRQQKRYKRADEIKEAWIRNWDEHNHNVQDLYCESKVWQAKPYDPPHVDCVKRAEVTSYNGIPSGPQKVPICVINAVTPIPTMYTWAPTQQNFMVEDETVLHNIPYMGDEVLDKDGKFIEELIKNYDGKVHGDKDPSFMDDAIFVELVHALMRSYSKELEEAAPGTATAIKTETLAKSKQGEDDGVVDVDADGESPMKLEKTDSKGDLTEVEKKETEEPLETEDADVKPDVEEVKDKLPFPAPIIFQAISANFPDKGTAQELKEKYIELTEHQDPERPQECTPNIDGIKAESVSRERTMHSFHTLFCRRCFKYDCFLHRLQGHAGPNLQKRRYPELKPFAEPCSNSCYMLIDGMKEKLAADSKTPPIDSCNEASSEDSNDSNSQFSNKDFNHENSKDNGLTVNSAAVAEINSIMAGMMNITSTQCVWTGADQALYRVLHKVYLKNYCAIAHNMLTKTCRQVYEFAQKEDAEFSFEDLRQDFTPPRKKKKKQRLWSLHCRKIQLKKDSSSNHVYNYTPCDHPGHPCDMNCSCIQTQNFCEKFCNCSSDCQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCQACGADQFKLTKITCKNVCVQRGLHKHLLMAPSDIAGWGIFLKEGAQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSINPNCYAKVMMVTGDHRIGIFAKRAIQPGEELFFDYRYGPTEQLKFVGIEREMEIV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Acetylation	RVKSEYIKIRQQKRY HHHHHHHHHHHHHHH	30.82	21791702
493	Phosphorylation	QKEDAEFSFEDLRQD HHHCCCCCHHHHHHH	21.16	22817900
502	Phosphorylation	EDLRQDFTPPRKKKK HHHHHHCCCCCHHHH	40.44	12408864
515	Phosphorylation	KKKQRLWSLHCRKIQ HHHHHHHHHCCEEEE	16.90	22817900
727	Acetylation	HRIGIFAKRAIQPGE CEEEEEEECCCCCCC	31.45	21791702

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of EZ_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of EZ_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of EZ_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PCL_DROME	Pcl	physical	12697833
SUZ12_DROME	Su(z)12	physical	12697833
EZ_DROME	E(z)	physical	12697833
HDAC1_DROME	Rpd3	physical	12697833
ESC_DROME	esc	physical	12697833
ESC_DROME	esc	physical	11124122
HDAC1_DROME	Rpd3	physical	11124122
CAF1_DROME	Caf1	physical	11124122
PCL_DROME	Pcl	physical	11571280
ESC_DROME	esc	physical	9566901
MTMR5_HUMAN	SBF1	physical	9537414
HP1_DROME	Su(var)205	physical	12408863
SUZ12_DROME	Su(z)12	physical	12408864
EZ_DROME	E(z)	physical	12408864
SIR2_DROME	Sir2	genetic	15498488
DOM_DROME	dom	genetic	11262242
PIWI_DROME	piwi	physical	26780607
ESC_DROME	esc	physical	26063573
ESC_DROME	esc	physical	11571280
ESC_DROME	esc	physical	12408864
ESC_DROME	esc	physical	15175158
ESC_DROME	esc	physical	15776017
ESC_DROME	esc	physical	9693151
JING_DROME	jing	physical	26063573
PCL_DROME	Pcl	physical	26063573
HSP27_DROME	Hsp27	physical	26063573
CORTO_DROME	corto	physical	26780607
SCM_DROME	Scm	physical	26063573
CAF1_DROME	Caf1	physical	26063573
CAF1_DROME	Caf1	physical	15776017
RING1_DROME	Sce	physical	25415640
PHO_DROME	pho	physical	15175158
SUZ12_DROME	Su(z)12	physical	25242320
SUZ12_DROME	Su(z)12	physical	26063573
SUZ12_DROME	Su(z)12	physical	15776017
SUZ12_DROME	Su(z)12	physical	24100017
SUZ12_DROME	Su(z)12	physical	12408863
SUZ12_DROME	Su(z)12	physical	22923582

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of EZ_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-493 AND THR-502, ANDMASS SPECTROMETRY.	18327897 [Abstract]