MTMR5_HUMAN - dbPTM
MTMR5_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MTMR5_HUMAN
UniProt AC O95248
Protein Name Myotubularin-related protein 5
Gene Name SBF1
Organism Homo sapiens (Human).
Sequence Length 1868
Subcellular Localization Nucleus .
Protein Description Probable pseudophosphatase. Lacks several amino acids in the catalytic pocket which renders it catalytically inactive as a phosphatase. The pocket is however sufficiently preserved to bind phosphorylated substrates, and maybe protect them from phosphatases. Inhibits myoblast differentiation in vitro and induces oncogenic transformation in fibroblasts. According to PubMed:20937701, may function as a guanine nucleotide exchange factor (GEF) activating RAB28. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form..
Protein Sequence MARLADYFVLVAFGPHPRGSGEGQGQILQRFPEKDWEDNPFPQGIELFCQPSGWQLCPERNPPTFFVAVLTDINSERHYCACLTFWEPAEPSQQETTRVEDATEREEEGDEGGQTHLSPTAPAPSAQLFAPKTLVLVSRLDHTEVFRNSLGLIYAIHVEGLNVCLENVIGNLLTCTVPLAGGSQRTISLGAGDRQVIQTPLADSLPVSRCSVALLFRQLGITNVLSLFCAALTEHKVLFLSRSYQRLADACRGLLALLFPLRYSFTYVPILPAQLLEVLSTPTPFIIGVNAAFQAETQELLDVIVADLDGGTVTIPECVHIPPLPEPLQSQTHSVLSMVLDPELELADLAFPPPTTSTSSLKMQDKELRAVFLRLFAQLLQGYRWCLHVVRIHPEPVIRFHKAAFLGQRGLVEDDFLMKVLEGMAFAGFVSERGVPYRPTDLFDELVAHEVARMRADENHPQRVLRHVQELAEQLYKNENPYPAVAMHKVQRPGESSHLRRVPRPFPRLDEGTVQWIVDQAAAKMQGAPPAVKAERRTTVPSGPPMTAILERCSGLHVNSARRLEVVRNCISYVFEGKMLEAKKLLPAVLRALKGRAARRCLAQELHLHVQQNRAVLDHQQFDFVVRMMNCCLQDCTSLDEHGIAAALLPLVTAFCRKLSPGVTQFAYSCVQEHVVWSTPQFWEAMFYGDVQTHIRALYLEPTEDLAPAQEVGEAPSQEDERSALDVASEQRRLWPTLSREKQQELVQKEESTVFSQAIHYANRMSYLLLPLDSSKSRLLRERAGLGDLESASNSLVTNSMAGSVAESYDTESGFEDAETCDVAGAVVRFINRFVDKVCTESGVTSDHLKGLHVMVPDIVQMHIETLEAVQRESRRLPPIQKPKLLRPRLLPGEECVLDGLRVYLLPDGREEGAGGSAGGPALLPAEGAVFLTTYRVIFTGMPTDPLVGEQVVVRSFPVAALTKEKRISVQTPVDQLLQDGLQLRSCTFQLLKMAFDEEVGSDSAELFRKQLHKLRYPPDIRATFAFTLGSAHTPGRPPRVTKDKGPSLRTLSRNLVKNAKKTIGRQHVTRKKYNPPSWEHRGQPPPEDQEDEISVSEELEPSTLTPSSALKPSDRMTMSSLVERACCRDYQRLGLGTLSSSLSRAKSEPFRISPVNRMYAICRSYPGLLIVPQSVQDNALQRVSRCYRQNRFPVVCWRSGRSKAVLLRSGGLHGKGVVGLFKAQNAPSPGQSQADSSSLEQEKYLQAVVSSMPRYADASGRNTLSGFSSAHMGSHGKWGSVRTSGRSSGLGTDVGSRLAGRDALAPPQANGGPPDPGFLRPQRAALYILGDKAQLKGVRSDPLQQWELVPIEVFEARQVKASFKKLLKACVPGCPAAEPSPASFLRSLEDSEWLIQIHKLLQVSVLVVELLDSGSSVLVGLEDGWDITTQVVSLVQLLSDPFYRTLEGFRLLVEKEWLSFGHRFSHRGAHTLAGQSSGFTPVFLQFLDCVHQVHLQFPMEFEFSQFYLKFLGYHHVSRRFRTFLLDSDYERIELGLLYEEKGERRGQVPCRSVWEYVDRLSKRTPVFHNYMYAPEDAEVLRPYSNVSNLKVWDFYTEETLAEGPPYDWELAQGPPEPPEEERSDGGAPQSRRRVVWPCYDSCPRAQPDAISRLLEELQRLETELGQPAERWKDTWDRVKAAQRLEGRPDGRGTPSSLLVSTAPHHRRSLGVYLQEGPVGSTLSLSLDSDQSSGSTTSGSRQAARRSTSTLYSQFQTAESENRSYEGTLYKKGAFMKPWKARWFVLDKTKHQLRYYDHRVDTECKGVIDLAEVEAVAPGTPTMGAPKTVDEKAFFDVKTTRRVYNFCAQDVPSAQQWVDRIQSCLSDA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
20PhosphorylationFGPHPRGSGEGQGQI
ECCCCCCCCCCCCCH		34.6427251275
20 (in isoform 4)Phosphorylation-34.6427251275
102PhosphorylationETTRVEDATEREEEG
CCCCCCCHHHCHHCC		48.1530108239
114PhosphorylationEEGDEGGQTHLSPTA
HCCCCCCCCCCCCCC		28.2326657352
117PhosphorylationDEGGQTHLSPTAPAP
CCCCCCCCCCCCCCC		16.7628387310
119PhosphorylationGGQTHLSPTAPAPSA
CCCCCCCCCCCCCHH		41.7330108239
187PhosphorylationAGGSQRTISLGAGDR
CCCCCEEEECCCCCC		21.82-
198PhosphorylationAGDRQVIQTPLADSL
CCCCEEEECCCCCCC		14.7825101063
203PhosphorylationVIQTPLADSLPVSRC
EEECCCCCCCCCCHH		29.0325101063
207PhosphorylationPLADSLPVSRCSVAL
CCCCCCCCCHHHHHH		26.1525101063
296PhosphorylationVNAAFQAETQELLDV
CCHHHHHHHHHHHHE		30.2924275569
355PhosphorylationDLAFPPPTTSTSSLK
HCCCCCCCCCCCHHC		35.46-
356PhosphorylationLAFPPPTTSTSSLKM
CCCCCCCCCCCHHCC		28.86-
357PhosphorylationAFPPPTTSTSSLKMQ
CCCCCCCCCCHHCCC		21.90-
401 (in isoform 4)Ubiquitination-38.40-
402UbiquitinationEPVIRFHKAAFLGQR
CCCHHHHHHHHHCCC		8.55-
475PhosphorylationVQELAEQLYKNENPY
HHHHHHHHHHCCCCC		16.09-
475 (in isoform 4)Phosphorylation-16.0925147952
495PhosphorylationHKVQRPGESSHLRRV
EECCCCCCCCCCCCC		29.0423312004
496PhosphorylationKVQRPGESSHLRRVP
ECCCCCCCCCCCCCC		23.4124275569
512PhosphorylationPFPRLDEGTVQWIVD
CCCCCCCCCHHHHHH		13.8928674419
523 (in isoform 4)Ubiquitination-27.34-
524UbiquitinationIVDQAAAKMQGAPPA
HHHHHHHHHCCCCCC		3.68-
532 (in isoform 4)Ubiquitination-46.79-
533UbiquitinationQGAPPAVKAERRTTV
CCCCCCCCCCCCCCC		14.66-
541PhosphorylationAERRTTVPSGPPMTA
CCCCCCCCCCCCHHH		60.6422210691
546PhosphorylationTVPSGPPMTAILERC
CCCCCCCHHHHHHHH		19.1320044836
553PhosphorylationMTAILERCSGLHVNS
HHHHHHHHCCCCCCH		51.0823312004
553 (in isoform 4)Phosphorylation-51.0827251275
559PhosphorylationRCSGLHVNSARRLEV
HHCCCCCCHHHHHHH		23.2829978859
559 (in isoform 4)Phosphorylation-23.2827251275
728PhosphorylationERSALDVASEQRRLW
HHHHHHHHHHHHHHH		33.8330576142
736PhosphorylationSEQRRLWPTLSREKQ
HHHHHHHHHCCHHHH		26.2824719451
736 (in isoform 4)Phosphorylation-26.2824719451
738PhosphorylationQRRLWPTLSREKQQE
HHHHHHHCCHHHHHH		40.6524719451
738 (in isoform 4)Phosphorylation-40.6524719451
765PhosphorylationAIHYANRMSYLLLPL
HHHHHHHHHEEEEEC		14.9128796482
766PhosphorylationIHYANRMSYLLLPLD
HHHHHHHHEEEEECC		7.6328796482
773PhosphorylationSYLLLPLDSSKSRLL
HEEEEECCCHHHHHH		47.5528796482
774PhosphorylationYLLLPLDSSKSRLLR
EEEEECCCHHHHHHH		34.0328796482
775UbiquitinationLLLPLDSSKSRLLRE
EEEECCCHHHHHHHH		43.4722505724
775 (in isoform 4)Ubiquitination-43.47-
776UbiquitinationLLPLDSSKSRLLRER
EEECCCHHHHHHHHH		30.06-
776PhosphorylationLLPLDSSKSRLLRER
EEECCCHHHHHHHHH		30.0629083192
784UbiquitinationSRLLRERAGLGDLES
HHHHHHHCCCCCHHH		36.0922505724
785UbiquitinationRLLRERAGLGDLESA
HHHHHHCCCCCHHHH		4.7522505724
790PhosphorylationRAGLGDLESASNSLV
HCCCCCHHHHHHHHC		44.2722210691
794PhosphorylationGDLESASNSLVTNSM
CCHHHHHHHHCCCCC		23.01-
797PhosphorylationESASNSLVTNSMAGS
HHHHHHHCCCCCCCH		27.20-
799PhosphorylationASNSLVTNSMAGSVA
HHHHHCCCCCCCHHH		10.72-
812PhosphorylationVAESYDTESGFEDAE
HHHHCCCCCCCCCHH		51.3722210691
819PhosphorylationESGFEDAETCDVAGA
CCCCCCHHHCCHHHH		18.7422210691
836 (in isoform 4)Ubiquitination-33.63-
837UbiquitinationFINRFVDKVCTESGV
HHHHHHHHHHHCCCC		4.17-
968PhosphorylationALTKEKRISVQTPVD
HCCCCCCCCCCCCHH		16.5322199227
971PhosphorylationKEKRISVQTPVDQLL
CCCCCCCCCCHHHHH		24.1122199227
1023PhosphorylationRYPPDIRATFAFTLG
CCCCCHHHEEEEECC		12.9727080861
1027PhosphorylationDIRATFAFTLGSAHT
CHHHEEEEECCCCCC		27.1228152594
1027 (in isoform 4)Phosphorylation-27.1224719451
1029PhosphorylationRATFAFTLGSAHTPG
HHEEEEECCCCCCCC		21.5232142685
1030PhosphorylationATFAFTLGSAHTPGR
HEEEEECCCCCCCCC		21.7129255136
1030 (in isoform 4)Phosphorylation-21.7127251275
1033PhosphorylationAFTLGSAHTPGRPPR
EEECCCCCCCCCCCC		27.4429255136
1073PhosphorylationRQHVTRKKYNPPSWE
CHHCCCCCCCCCCCC		35.6223927012
1077PhosphorylationTRKKYNPPSWEHRGQ
CCCCCCCCCCCCCCC		46.4825159151
1077 (in isoform 4)Phosphorylation-46.4824719451
1094PhosphorylationPEDQEDEISVSEELE
CCCCCCCCCCCCCCC		19.9726657352
1094 (in isoform 4)Phosphorylation-19.9727251275
1096PhosphorylationDQEDEISVSEELEPS
CCCCCCCCCCCCCCC		20.6827251275
1117PhosphorylationALKPSDRMTMSSLVE
CCCCCCCCCHHHHHH		18.1320068231
1119PhosphorylationKPSDRMTMSSLVERA
CCCCCCCHHHHHHHH		16.0225850435
1119 (in isoform 4)Phosphorylation-16.0224719451
1120PhosphorylationPSDRMTMSSLVERAC
CCCCCCHHHHHHHHH		26.1328348404
1120 (in isoform 4)Phosphorylation-26.1327251275
1121PhosphorylationSDRMTMSSLVERACC
CCCCCHHHHHHHHHC		3.4823186163
1130PhosphorylationVERACCRDYQRLGLG
HHHHHCCCHHHHCHH		4.0030301811
1136PhosphorylationRDYQRLGLGTLSSSL
CCHHHHCHHHHCHHH		23.8632142685
1137PhosphorylationDYQRLGLGTLSSSLS
CHHHHCHHHHCHHHH		28.6329255136
1137 (in isoform 4)Phosphorylation-28.6324719451
1138PhosphorylationYQRLGLGTLSSSLSR
HHHHCHHHHCHHHHH		4.4223186163
1139PhosphorylationQRLGLGTLSSSLSRA
HHHCHHHHCHHHHHH		20.0930266825
1139 (in isoform 4)Phosphorylation-20.0927251275
1140PhosphorylationRLGLGTLSSSLSRAK
HHCHHHHCHHHHHHC		38.1130266825
1141PhosphorylationLGLGTLSSSLSRAKS
HCHHHHCHHHHHHCC		27.3028355574
1141 (in isoform 4)Phosphorylation-27.3024719451
1143PhosphorylationLGTLSSSLSRAKSEP
HHHHCHHHHHHCCCC		31.9428122231
1222MethylationGKGVVGLFKAQNAPS
CCCEEEEEECCCCCC		54.8524129315
1222UbiquitinationGKGVVGLFKAQNAPS
CCCEEEEEECCCCCC		54.8529967540
1223MethylationKGVVGLFKAQNAPSP
CCEEEEEECCCCCCC		10.6724129315
1228PhosphorylationLFKAQNAPSPGQSQA
EEECCCCCCCCCCCC		38.9729255136
1228 (in isoform 4)Phosphorylation-38.9727251275
1232PhosphorylationQNAPSPGQSQADSSS
CCCCCCCCCCCCCCH		33.0029255136
1236PhosphorylationSPGQSQADSSSLEQE
CCCCCCCCCCHHHHH		25.4929396449
1244PhosphorylationSSSLEQEKYLQAVVS
CCHHHHHHHHHHHHH		11.8624732914
1250PhosphorylationEKYLQAVVSSMPRYA
HHHHHHHHHCCCCCC		17.8324732914
1251PhosphorylationKYLQAVVSSMPRYAD
HHHHHHHHCCCCCCC		22.6124732914
1255PhosphorylationAVVSSMPRYADASGR
HHHHCCCCCCCCCCC		11.71-
1259PhosphorylationSMPRYADASGRNTLS
CCCCCCCCCCCCCCC		38.54-
1259 (in isoform 4)Phosphorylation-38.54-
1263PhosphorylationYADASGRNTLSGFSS
CCCCCCCCCCCCCCC		22.42-
1263 (in isoform 4)Phosphorylation-22.4225850435
1265 (in isoform 4)Phosphorylation-35.4425850435
1269 (in isoform 4)Phosphorylation-21.6722210691
1274PhosphorylationGFSSAHMGSHGKWGS
CCCCCCCCCCCCCCC		22.8428555341
1274 (in isoform 4)Phosphorylation-22.8422210691
1278 (in isoform 4)Phosphorylation-14.6421712546
1280PhosphorylationMGSHGKWGSVRTSGR
CCCCCCCCCCCCCCC		13.8126074081
1280 (in isoform 4)Methylation-13.81-
1283PhosphorylationHGKWGSVRTSGRSSG
CCCCCCCCCCCCCCC		33.1226074081
1284PhosphorylationGKWGSVRTSGRSSGL
CCCCCCCCCCCCCCC		22.9626074081
1284 (in isoform 4)Phosphorylation-22.9628634298
1285 (in isoform 4)Phosphorylation-32.6428634298
1287PhosphorylationGSVRTSGRSSGLGTD
CCCCCCCCCCCCCCC		32.0826074081
1287 (in isoform 4)Phosphorylation-32.0827251275
1288PhosphorylationSVRTSGRSSGLGTDV
CCCCCCCCCCCCCCH		36.3524719451
1292PhosphorylationSGRSSGLGTDVGSRL
CCCCCCCCCCHHHHH		32.33-
1293 (in isoform 4)Phosphorylation-40.7727251275
1296PhosphorylationSGLGTDVGSRLAGRD
CCCCCCHHHHHCCCC		24.7828857561
1306 (in isoform 4)Phosphorylation-23.5324719451
1314 (in isoform 4)Phosphorylation-64.8024719451
1362PhosphorylationFEARQVKASFKKLLK
HHHHHHHHHHHHHHH		31.7024719451
1383PhosphorylationPAAEPSPASFLRSLE
CCCCCCHHHHHHHCC		28.3524719451
1388 (in isoform 4)Phosphorylation-7.3824719451
1517PhosphorylationKFLGYHHVSRRFRTF
HHHCHHHHHHHHHHH		17.24-
1527PhosphorylationRFRTFLLDSDYERIE
HHHHHHCCCCHHHHH		41.9028152594
1529PhosphorylationRTFLLDSDYERIELG
HHHHCCCCHHHHHHH		15.8528152594
1538PhosphorylationERIELGLLYEEKGER
HHHHHHEEECCCCCC		27.38-
1564 (in isoform 4)Phosphorylation-27.7825147952
1623PhosphorylationPEPPEEERSDGGAPQ
CCCCHHHCCCCCCCC		43.8424275569
1639PhosphorylationRRRVVWPCYDSCPRA
CCEEEEECCCCCCCC		13.5520068231
1641PhosphorylationRVVWPCYDSCPRAQP
EEEEECCCCCCCCCH		10.2720068231
1674PhosphorylationQPAERWKDTWDRVKA
CCHHHHHHHHHHHHH		26.0726657352
1693PhosphorylationEGRPDGRGTPSSLLV
CCCCCCCCCCHHEEE		20.7329255136
1695PhosphorylationRPDGRGTPSSLLVST
CCCCCCCCHHEEEEC		33.1929255136
1696PhosphorylationPDGRGTPSSLLVSTA
CCCCCCCHHEEEECC		27.2529255136
1700PhosphorylationGTPSSLLVSTAPHHR
CCCHHEEEECCCCCC		20.8723312004
1701PhosphorylationTPSSLLVSTAPHHRR
CCHHEEEECCCCCCC		36.4123312004
1721 (in isoform 4)Phosphorylation-17.9027251275
1725PhosphorylationPVGSTLSLSLDSDQS
CCCCEEEEEECCCCC		27.1022210691
1732PhosphorylationLSLDSDQSSGSTTSG
EEECCCCCCCCCCCC		31.0022210691
1734PhosphorylationLDSDQSSGSTTSGSR
ECCCCCCCCCCCCHH		30.3822210691
1746PhosphorylationGSRQAARRSTSTLYS
CHHHHHHHHHHHHHH		22.5823401153
1747PhosphorylationSRQAARRSTSTLYSQ
HHHHHHHHHHHHHHH		24.7421945579
1748PhosphorylationRQAARRSTSTLYSQF
HHHHHHHHHHHHHHH		20.0523401153
1749PhosphorylationQAARRSTSTLYSQFQ
HHHHHHHHHHHHHHH		29.7821945579
1751PhosphorylationARRSTSTLYSQFQTA
HHHHHHHHHHHHHCC		10.6621945579
1752PhosphorylationRRSTSTLYSQFQTAE
HHHHHHHHHHHHCCC		27.8621945579
1756PhosphorylationSTLYSQFQTAESENR
HHHHHHHHCCCCCCC		33.4121945579
1763PhosphorylationQTAESENRSYEGTLY
HCCCCCCCCEEEEEE		38.8325954137
1767PhosphorylationSENRSYEGTLYKKGA
CCCCCEEEEEEECCC		18.2525954137
1769PhosphorylationNRSYEGTLYKKGAFM
CCCEEEEEEECCCCC		15.5325954137
1770AcetylationRSYEGTLYKKGAFMK
CCEEEEEEECCCCCC		48.0925953088
1770MalonylationRSYEGTLYKKGAFMK
CCEEEEEEECCCCCC		48.0926320211
1772PhosphorylationYEGTLYKKGAFMKPW
EEEEEEECCCCCCCE		21.6420068231
1772 (in isoform 4)Phosphorylation-21.6424719451
1773 (in isoform 4)Phosphorylation-15.3927642862
1774PhosphorylationGTLYKKGAFMKPWKA
EEEEECCCCCCCEEE		9.8518669648
1774 (in isoform 4)Phosphorylation-9.8527642862
1775 (in isoform 4)Phosphorylation-5.1627642862
1777 (in isoform 4)Phosphorylation-26.4727642862
1819PhosphorylationEVEAVAPGTPTMGAP
HEEEECCCCCCCCCC		17.9625850435
1821PhosphorylationEAVAPGTPTMGAPKT
EEECCCCCCCCCCCC		28.2422199227
1832UbiquitinationAPKTVDEKAFFDVKT
CCCCCCCCCCCCCCC		14.3230230243
1845 (in isoform 4)Phosphorylation-1.6827251275
1857UbiquitinationDVPSAQQWVDRIQSC
CCCCHHHHHHHHHHH		2.8530230243
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MTMR5_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MTMR5_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MTMR5_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MTMR2_HUMANMTMR2physical
12668758
SUV91_HUMANSUV39H1physical
10848615
CO1A2_HUMANCOL1A2physical
27880917
MTMR1_HUMANMTMR1physical
27880917
MTMR2_HUMANMTMR2physical
27880917
KAPCA_HUMANPRKACAphysical
27880917
RPAP3_HUMANRPAP3physical
27880917
SP16H_HUMANSUPT16Hphysical
27880917
WDR55_HUMANWDR55physical
27880917
MTMR5_HUMANSBF1physical
27432908
MTMR1_HUMANMTMR1physical
27432908
MTMR2_HUMANMTMR2physical
27432908
UQCC1_HUMANUQCC1physical
27432908
UQCC2_HUMANUQCC2physical
27432908
RAB35_HUMANRAB35physical
27432908
IFT27_HUMANIFT27physical
27432908
CT2NL_HUMANCTTNBP2NLphysical
27432908
STIP1_HUMANSTIP1physical
27432908
IFT52_HUMANIFT52physical
27432908
RT16_HUMANMRPS16physical
27432908
PTG3L_HUMANPTGES3Lphysical
27432908
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
615284Charcot-Marie-Tooth disease 4B3 (CMT4B3)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MTMR5_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1137, AND MASSSPECTROMETRY.

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