UQCC2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UQCC2_HUMAN
• UniProt AC: Q9BRT2
• Protein Name: Ubiquinol-cytochrome-c reductase complex assembly factor 2
• Gene Name: UQCC2
• Organism: Homo sapiens (Human).
• Sequence Length: 126
• Subcellular Localization: Mitochondrion matrix, mitochondrion nucleoid. Mitochondrion. Mitochondrion intermembrane space. Mitochondrion matrix. Mitochondrion inner membrane. Predominantly expressed in the mitochondrial inner membrane..
• Protein Description: Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex). Plays a role in the modulation of respiratory chain activities such as oxygen consumption and ATP production and via its modulation of the respiratory chain activity can regulate skeletal muscle differentiation and insulin secretion by pancreatic beta-cells. Involved in cytochrome b translation and/or stability..
• Protein Sequence: MAASRYRRFLKLCEEWPVDETKRGRDLGAYLRQRVAQAFREGENTQVAEPEACDQMYESLARLHSNYYKHKYPRPRDTSFSGLSLEEYKLILSTDTLEELKEIDKGMWKKLQEKFAPKGPEEDHKA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Acetylation	SRYRRFLKLCEEWPV HHHHHHHHHHHHCCC		26822725
45	Phosphorylation	AFREGENTQVAEPEA HHHHCCCCCCCCHHH		29978859
53	S-palmitoylation	QVAEPEACDQMYESL CCCCHHHHHHHHHHH		19801377
57	Phosphorylation	PEACDQMYESLARLH HHHHHHHHHHHHHHH		29978859
59	Phosphorylation	ACDQMYESLARLHSN HHHHHHHHHHHHHHC		29978859
67	Phosphorylation	LARLHSNYYKHKYPR HHHHHHCHHCCCCCC		-
72	Phosphorylation	SNYYKHKYPRPRDTS HCHHCCCCCCCCCCC		-
79	Phosphorylation	YPRPRDTSFSGLSLE CCCCCCCCCCCCCHH		23532336
84	Phosphorylation	DTSFSGLSLEEYKLI CCCCCCCCHHHHHHH		23532336
88	Phosphorylation	SGLSLEEYKLILSTD CCCCHHHHHHHHCCC		-
93	Phosphorylation	EEYKLILSTDTLEEL HHHHHHHCCCCHHHH		28348404
94	Phosphorylation	EYKLILSTDTLEELK HHHHHHCCCCHHHHH		28348404
96	Phosphorylation	KLILSTDTLEELKEI HHHHCCCCHHHHHHH		28348404
101	Ubiquitination	TDTLEELKEIDKGMW CCCHHHHHHHCHHHH		29967540
101	Acetylation	TDTLEELKEIDKGMW CCCHHHHHHHCHHHH		26822725
114	Acetylation	MWKKLQEKFAPKGPE HHHHHHHHHCCCCCH		27452117
118	Acetylation	LQEKFAPKGPEEDHK HHHHHCCCCCHHHCC		11789997

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UQCC2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UQCC2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UQCC2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CEAM5_HUMAN	CEACAM5	physical	21988832
UQCC1_HUMAN	UQCC1	physical	24385928
CDR2_HUMAN	CDR2	physical	27173435
URFB1_HUMAN	UHRF1BP1	physical	27173435

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.