URFB1_HUMAN - dbPTM
URFB1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID URFB1_HUMAN
UniProt AC Q6BDS2
Protein Name UHRF1-binding protein 1
Gene Name UHRF1BP1
Organism Homo sapiens (Human).
Sequence Length 1440
Subcellular Localization
Protein Description May act as a negative regulator of cell growth..
Protein Sequence MAGIIKKQILKHLSRFTKNLSPDKINLSTLKGEGQLTNLELDEEVLQNVLELPTWLAITRVYCNRASIRIQWTKLKTHPICLCLDKVEVEMKTCEDPRPPNGQSPIALASGQSEYGFAEKVVEGMFIIVNSITIKIHSKAFHASFELWQLQGYSVNPNWQQSDLRLTRITDPCRGEVLTFKEITWQTLRIEADATDNGDQDPVTTPLRLITNQGRIQIALKRRTKDCNVISSKLMFLLDDLLWVLTDSQLKAMMKYAESLSEAMEKSAHQRKSLAPEPVQITPPAPSAQQSWAQAFGGSQGNSNSSSSRLSQYFEKFDVKESSYHLLISRLDLHICDDSQSREPGVSANRLMGGAMQLTFRKMAFDYYPFHWAGDSCKHWVRHCEAMETRGQWAQKLVMEFQSKMEKWHEETGLKPPWHLGVDSLFRRKADSLSSPRKNPLERSPSQGRQPAFQPPAWNRLRSSCMVVRVDDLDIHQVSTAGQPSKKPSTLLSCSRKLHNLPTQVSAIHIEFTEYYFPDNQELPVPCPNLYIQLNGLTFTMDPVSLLWGNLFCLDLYRSLEQFKAIYKLEDSSQKDEHLDIRLDAFWLKVSFPLEKRERAELHRPQALVFSASGMIATNTRHAPHCSCSDLQSLFRGFAAAEFFHSNYDHFPKVPGGFSLLHMLFLHHAFQMDSCLPQPNTLPPQRPKASWDLWSVHFTQISLDFEGTENFKGHTLNFVAPFPLSIWACLPLRWQQAQARKLLLASEGRLKPSASFGSPVQSEALAPDSMSHPRSKTEHDLKSLSGLTEVMEILKEGSSGMDNKGPLTELEDVADVHMLVHSPAHVRVRLDHYQYLALLRLKEVLQRLQEQLTKDTESMTGSPLQNQTACIGVLFPSAEVALLMHPAPGAVDADSAGSDSTSLVDSELSPSEDRELKSDASSDQGPASPEKVLEESSIENQDVSQERPHSNGELQDSGPLAQQLAGKGHEAVESLQAKKLSRTQASSSPAALKPPAGRETAVNGQGELIPLKNIEGELSSAIHMTKDATKEALHATMDLTKEAVSLTKDAFSLGRDRMTSTMHKMLSLPPAKEPMAKTDEGVAAPVSGGAARLRFFSMKRTVSQQSFDGVSLDSSGPEDRISVDSDGSDSFVMLLESESGPESVPPGSLSNVSDNAGVQGSPLVNNYGQGSPAANSSVSPSGEDLIFHPVSVLVLKVNEVSFGIEVRGEDLTVALQAEELTLQQLGTVGLWQFLHGQCPGTCFQESSTLKTGHIRPAVGLRFEVGPGAAVHSPLASQNGFLHLLLHGCDLELLTSVLSGLGPFLEDEEIPVVVPMQIELLNSSITLKDDIPPIYPTSPGPIPITLAMEHVVLKRSDDGVFHIGAAAQDKPSAEVLKSEKRQPPKEQVFLVPTGEVFEQQVKELPILQKELIETKQALANANQDKEKLLQEIRKYNPFFEL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
6Acetylation--MAGIIKKQILKHL
--CCCHHHHHHHHHH		36.3830593237
14PhosphorylationKQILKHLSRFTKNLS
HHHHHHHHHHHCCCC		25.6822817900
21PhosphorylationSRFTKNLSPDKINLS
HHHHCCCCCCCEEHH		40.2120873877
24UbiquitinationTKNLSPDKINLSTLK
HCCCCCCCEEHHHCC		36.56-
104PhosphorylationPRPPNGQSPIALASG
CCCCCCCCCCEEECC		21.4822210691
133PhosphorylationFIIVNSITIKIHSKA
EEEEEEEEEEEECHH		18.9522210691
138PhosphorylationSITIKIHSKAFHASF
EEEEEEECHHHCEEE		29.2022210691
221UbiquitinationGRIQIALKRRTKDCN
CCEEEEECCCCCCCC		30.71-
224PhosphorylationQIALKRRTKDCNVIS
EEEECCCCCCCCCHH		34.9623898821
225UbiquitinationIALKRRTKDCNVISS
EEECCCCCCCCCHHH		59.4829967540
231PhosphorylationTKDCNVISSKLMFLL
CCCCCCHHHHHHHHH		19.6923898821
232PhosphorylationKDCNVISSKLMFLLD
CCCCCHHHHHHHHHH		20.7723898821
251UbiquitinationVLTDSQLKAMMKYAE
HHCHHHHHHHHHHHH		26.97-
272UbiquitinationEKSAHQRKSLAPEPV
HHHHHHCCCCCCCCC		43.1629967540
273PhosphorylationKSAHQRKSLAPEPVQ
HHHHHCCCCCCCCCC		31.7727251275
282PhosphorylationAPEPVQITPPAPSAQ
CCCCCCCCCCCCCHH		13.2128102081
287PhosphorylationQITPPAPSAQQSWAQ
CCCCCCCCHHHHHHH		40.5927251275
291PhosphorylationPAPSAQQSWAQAFGG
CCCCHHHHHHHHHCC		16.5827251275
299PhosphorylationWAQAFGGSQGNSNSS
HHHHHCCCCCCCCCC		34.9827251275
303PhosphorylationFGGSQGNSNSSSSRL
HCCCCCCCCCCHHHH		44.9327251275
305PhosphorylationGSQGNSNSSSSRLSQ
CCCCCCCCCHHHHHH		31.2727251275
306PhosphorylationSQGNSNSSSSRLSQY
CCCCCCCCHHHHHHH		36.2627251275
307PhosphorylationQGNSNSSSSRLSQYF
CCCCCCCHHHHHHHH		21.2127251275
308PhosphorylationGNSNSSSSRLSQYFE
CCCCCCHHHHHHHHH		38.9127251275
311PhosphorylationNSSSSRLSQYFEKFD
CCCHHHHHHHHHHCC		23.0223403867
313PhosphorylationSSSRLSQYFEKFDVK
CHHHHHHHHHHCCCC		15.4423403867
316UbiquitinationRLSQYFEKFDVKESS
HHHHHHHHCCCCHHH		36.6423000965
320UbiquitinationYFEKFDVKESSYHLL
HHHHCCCCHHHHEEE		54.4423000965
359PhosphorylationMGGAMQLTFRKMAFD
HHHHHHHHHHHHHHC		12.4222210691
368PhosphorylationRKMAFDYYPFHWAGD
HHHHHCCCCCCCCCC		10.9830576142
376PhosphorylationPFHWAGDSCKHWVRH
CCCCCCCCCHHHHHH		24.9330576142
432PhosphorylationLFRRKADSLSSPRKN
HHHHHHHCCCCCCCC		34.7020068231
434PhosphorylationRRKADSLSSPRKNPL
HHHHHCCCCCCCCCC		42.1027794612
435PhosphorylationRKADSLSSPRKNPLE
HHHHCCCCCCCCCCC		33.7325159151
444PhosphorylationRKNPLERSPSQGRQP
CCCCCCCCCCCCCCC		21.3725159151
446PhosphorylationNPLERSPSQGRQPAF
CCCCCCCCCCCCCCC		46.6528464451
479PhosphorylationDLDIHQVSTAGQPSK
CCEEEEECCCCCCCC		13.13-
480PhosphorylationLDIHQVSTAGQPSKK
CEEEEECCCCCCCCC		35.63-
485PhosphorylationVSTAGQPSKKPSTLL
ECCCCCCCCCHHHHH		45.48-
489PhosphorylationGQPSKKPSTLLSCSR
CCCCCCHHHHHHHCH		40.33-
490PhosphorylationQPSKKPSTLLSCSRK
CCCCCHHHHHHHCHH		40.0024114839
741UbiquitinationWQQAQARKLLLASEG
HHHHHHHHHHHHCCC		46.6429901268
751UbiquitinationLASEGRLKPSASFGS
HHCCCCCCCCCCCCC		35.2529967540
753PhosphorylationSEGRLKPSASFGSPV
CCCCCCCCCCCCCCC		34.6523401153
755PhosphorylationGRLKPSASFGSPVQS
CCCCCCCCCCCCCCC		34.1823401153
758PhosphorylationKPSASFGSPVQSEAL
CCCCCCCCCCCCCCC		21.6425159151
762PhosphorylationSFGSPVQSEALAPDS
CCCCCCCCCCCCCCC		25.6821712546
775PhosphorylationDSMSHPRSKTEHDLK
CCCCCCCCCCHHHHH		48.6728348404
777PhosphorylationMSHPRSKTEHDLKSL
CCCCCCCCHHHHHHC		39.5428348404
782UbiquitinationSKTEHDLKSLSGLTE
CCCHHHHHHCCCHHH		56.2429967540
783PhosphorylationKTEHDLKSLSGLTEV
CCHHHHHHCCCHHHH		34.7628348404
785PhosphorylationEHDLKSLSGLTEVME
HHHHHHCCCHHHHHH		38.5628348404
795UbiquitinationTEVMEILKEGSSGMD
HHHHHHHHHCCCCCC		66.7329967540
798PhosphorylationMEILKEGSSGMDNKG
HHHHHHCCCCCCCCC		25.4729449344
799PhosphorylationEILKEGSSGMDNKGP
HHHHHCCCCCCCCCC		49.3329449344
909PhosphorylationSLVDSELSPSEDREL
CCCCCCCCCCCCCHH		23.48-
911PhosphorylationVDSELSPSEDRELKS
CCCCCCCCCCCHHCC		49.07-
918PhosphorylationSEDRELKSDASSDQG
CCCCHHCCCCCCCCC		51.5423663014
921PhosphorylationRELKSDASSDQGPAS
CHHCCCCCCCCCCCC		39.1625159151
922PhosphorylationELKSDASSDQGPASP
HHCCCCCCCCCCCCH		35.3625159151
928PhosphorylationSSDQGPASPEKVLEE
CCCCCCCCHHHHHHH		36.4023663014
936PhosphorylationPEKVLEESSIENQDV
HHHHHHHHCCCCCCC		27.5227080861
937PhosphorylationEKVLEESSIENQDVS
HHHHHHHCCCCCCCC		36.8825850435
944PhosphorylationSIENQDVSQERPHSN
CCCCCCCCCCCCCCC		34.3126657352
950PhosphorylationVSQERPHSNGELQDS
CCCCCCCCCCCCCCC		49.5725159151
957PhosphorylationSNGELQDSGPLAQQL
CCCCCCCCCHHHHHH		29.3826657352
983PhosphorylationQAKKLSRTQASSSPA
HHHHCCCCCCCCCCC		25.7220068231
986PhosphorylationKLSRTQASSSPAALK
HCCCCCCCCCCCCCC		22.8720068231
987PhosphorylationLSRTQASSSPAALKP
CCCCCCCCCCCCCCC		43.2720068231
988PhosphorylationSRTQASSSPAALKPP
CCCCCCCCCCCCCCC		18.9625159151
993UbiquitinationSSSPAALKPPAGRET
CCCCCCCCCCCCCCC		44.2029967540
1019PhosphorylationKNIEGELSSAIHMTK
CCCCCCHHHHEECCH		17.2720068231
1020PhosphorylationNIEGELSSAIHMTKD
CCCCCHHHHEECCHH		43.8120068231
1025PhosphorylationLSSAIHMTKDATKEA
HHHHEECCHHHHHHH		16.1720068231
1047PhosphorylationTKEAVSLTKDAFSLG
HHHHHHHCHHHHHCC		21.2625599653
1048UbiquitinationKEAVSLTKDAFSLGR
HHHHHHCHHHHHCCH		52.9629967540
1052PhosphorylationSLTKDAFSLGRDRMT
HHCHHHHHCCHHHHH		31.4723879269
1059PhosphorylationSLGRDRMTSTMHKML
HCCHHHHHHHHHHHH		23.18-
1060PhosphorylationLGRDRMTSTMHKMLS
CCHHHHHHHHHHHHC		17.87-
1067PhosphorylationSTMHKMLSLPPAKEP
HHHHHHHCCCCCCCC		35.0228348404
1072"N6,N6-dimethyllysine"MLSLPPAKEPMAKTD
HHCCCCCCCCCCCCC		69.03-
1072MethylationMLSLPPAKEPMAKTD
HHCCCCCCCCCCCCC		69.03-
1078PhosphorylationAKEPMAKTDEGVAAP
CCCCCCCCCCCCCCC		29.7322617229
1087PhosphorylationEGVAAPVSGGAARLR
CCCCCCCCCHHHHHE		30.3725262027
1097PhosphorylationAARLRFFSMKRTVSQ
HHHHEEEEEEECCCC		22.2323186163
1101PhosphorylationRFFSMKRTVSQQSFD
EEEEEEECCCCCCCC		20.9930266825
1103PhosphorylationFSMKRTVSQQSFDGV
EEEEECCCCCCCCCC		23.1425159151
1106PhosphorylationKRTVSQQSFDGVSLD
EECCCCCCCCCCCCC		20.0525159151
1111PhosphorylationQQSFDGVSLDSSGPE
CCCCCCCCCCCCCCC		31.8030266825
1114PhosphorylationFDGVSLDSSGPEDRI
CCCCCCCCCCCCCCE		42.3530266825
1115PhosphorylationDGVSLDSSGPEDRIS
CCCCCCCCCCCCCEE		59.0230266825
1212PhosphorylationEVRGEDLTVALQAEE
EECCCEEEEEEEEEE		18.96-
1221PhosphorylationALQAEELTLQQLGTV
EEEEEEEHHHHHCHH		26.29-
1336PhosphorylationDIPPIYPTSPGPIPI
CCCCCCCCCCCCCCC		30.49-
1414UbiquitinationQKELIETKQALANAN
HHHHHHHHHHHHHCC		22.3029967540
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of URFB1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of URFB1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference
444Phosphorylation454 (10)Q ⇒ R;Lrs11755393
  • Systemic lupus erythematosus
19838195
446Phosphorylation454 (8)Q ⇒ R;Lrs11755393
  • Systemic lupus erythematosus
19838195
986Phosphorylation984 (2)Q ⇒ Hrs9469913
  • Body mass index
  • Body mass index in physically active individuals
  • Body mass index (joint analysis main effects and physical activity interaction)
28448500
987Phosphorylation984 (3)Q ⇒ Hrs9469913
  • Body mass index
  • Body mass index in physically active individuals
  • Body mass index (joint analysis main effects and physical activity interaction)
28448500
988Phosphorylation984 (4)Q ⇒ Hrs9469913
  • Body mass index
  • Body mass index in physically active individuals
  • Body mass index (joint analysis main effects and physical activity interaction)
28448500
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
UHRF1_HUMANUHRF1physical
15361834
CBY1_HUMANCBY1physical
27173435
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of URFB1_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1106, AND MASSSPECTROMETRY.
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1101; SER-1103 ANDSER-1106, AND MASS SPECTROMETRY.
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1103 AND SER-1106, ANDMASS SPECTROMETRY.

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