RT16_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RT16_HUMAN
• UniProt AC: Q9Y3D3
• Protein Name: 28S ribosomal protein S16, mitochondrial
• Gene Name: MRPS16
• Organism: Homo sapiens (Human).
• Sequence Length: 137
• Subcellular Localization: Mitochondrion .
• Protein Sequence: MVHLTTLLCKAYRGGHLTIRLALGGCTNRPFYRIVAAHNKCPRDGRFVEQLGSYDPLPNSHGEKLVALNLDRIRHWIGCGAHLSKPMEKLLGLAGFFPLHPMMITNAERLRRKRAREVLLASQKTDAEATDTEATET

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Methylation	TLLCKAYRGGHLTIR HHHHHHHCCCCEEEE	49.86	115483803
40	Ubiquitination	RIVAAHNKCPRDGRF HHHHCCCCCCCCCCH	35.43	24816145
64	Ubiquitination	LPNSHGEKLVALNLD CCCCCCCCEEEECHH	53.50	22817900
64	Ubiquitination	LPNSHGEKLVALNLD CCCCCCCCEEEECHH	53.50	21890473
64	Acetylation	LPNSHGEKLVALNLD CCCCCCCCEEEECHH	53.50	26051181
72	Methylation	LVALNLDRIRHWIGC EEEECHHHHHHHHCC	30.89	115483811
85	Malonylation	GCGAHLSKPMEKLLG CCCHHHCHHHHHHHH	55.53	26320211
85	Acetylation	GCGAHLSKPMEKLLG CCCHHHCHHHHHHHH	55.53	26051181
122	Phosphorylation	AREVLLASQKTDAEA HHHHHHHHCCCCCCC	31.98	22210691
125	Phosphorylation	VLLASQKTDAEATDT HHHHHCCCCCCCCCC	32.57	28176443
130	Phosphorylation	QKTDAEATDTEATET CCCCCCCCCCCCCCC	34.65	30278072
132	Phosphorylation	TDAEATDTEATET-- CCCCCCCCCCCCC--	24.14	30278072
135	Phosphorylation	EATDTEATET----- CCCCCCCCCC-----	33.65	28176443
137	Phosphorylation	TDTEATET------- CCCCCCCC-------	39.29	24732914

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RT16_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RT16_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RT16_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RT26_HUMAN	MRPS26	physical	22939629
RT25_HUMAN	MRPS25	physical	22939629
SSBP_HUMAN	SSBP1	physical	22939629

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 610498: Combined oxidative phosphorylation deficiency 2 (COXPD2)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-130, AND MASSSPECTROMETRY.
PubMed: 19690332

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-130, AND MASSSPECTROMETRY.
PubMed: 18669648

"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis.";
Wang B., Malik R., Nigg E.A., Korner R.;
Anal. Chem. 80:9526-9533(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-130, AND MASSSPECTROMETRY.
PubMed: 19007248