dbPTM

CT2NL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CT2NL_HUMAN
UniProt AC	Q9P2B4
Protein Name	CTTNBP2 N-terminal-like protein
Gene Name	CTTNBP2NL
Organism	Homo sapiens (Human).
Sequence Length	639
Subcellular Localization	Cytoplasm, cytoskeleton. Colocalizes with stress fibers..
Protein Description
Protein Sequence	MNLEKLSKPELLTLFSILEGELEARDLVIEALKAQHRDTFIEERYGKYNISDPLMALQRDFETLKEKNDGEKQPVCTNPLSILKVVMKQCKNMQERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKATNKAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNREENRTKTLKEEMESLKKIVKDLEASHQHSSPNEQLKKPVTVSKGTATEPLMLMSVFCQTESFPAERTHGSNIAKMTNTGLPGPATPAYSYAKTNGHCDPEIQTTRELTAGNNVENQVPPREKSVALAQEKPVENGGCPVGIETPVPMPSPLSSSGSSLSPSSTASSSLTSSPCSSPVLTKRLLGSSASSPGYQSSYQVGINQRFHAARHKFQSQADQDQQASGLQSPPSRDLSPTLIDNSAAKQLARNTVTQVLSRFTSQQGPIKPVSPNSSPFGTDYRNLANTANPRGDTSHSPTPGKVSSPLSPLSPGIKSPTIPRAERGNPPPIPPKKPGLTPSPSATTPLTKTHSQAASLTTAEDLASSCSSNTVVANGKDVELLLPTSS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
47	Ubiquitination	FIEERYGKYNISDPL HHHHHHCCCCCCHHH	26.62	23000965
48	Phosphorylation	IEERYGKYNISDPLM HHHHHCCCCCCHHHH	17.23	20068231
51	Phosphorylation	RYGKYNISDPLMALQ HHCCCCCCHHHHHHH	29.54	20068231
65	Ubiquitination	QRDFETLKEKNDGEK HHHHHHHHHCCCCCC	74.24	29967540
77	Phosphorylation	GEKQPVCTNPLSILK CCCCCCCCCHHHHHH	39.85	30387612
81	Phosphorylation	PVCTNPLSILKVVMK CCCCCHHHHHHHHHH	27.42	24719451
109	Dimethylation	AAAESRHRKVILDLE HHHHHHHHHEEECHH	33.55	-
110	Ubiquitination	AAESRHRKVILDLEE HHHHHHHHEEECHHH	27.74	29967540
138	Ubiquitination	DVTYMLEKERERLTQ CHHHHHHHHHHHHHH	59.10	29967540
165	Phosphorylation	EKEQKKLSSQLEEER HHHHHHHHHHHHHHH	25.56	20044836
176	Acetylation	EEERSRHKQLSSMLV HHHHHHHHHHHHHHH	52.39	7926823
187	Acetylation	SMLVLECKKATNKAA HHHHHHHHHHHHHHH	35.75	7926835
206	Ubiquitination	KAGELSLKLEKEKSR HHHHHHHHHHHHHHH	51.75	-
211	Ubiquitination	SLKLEKEKSRVSKLE HHHHHHHHHHHHHHH	55.41	-
264	Malonylation	ENRTKTLKEEMESLK HHHHHHHHHHHHHHH	57.78	26320211
271	Acetylation	KEEMESLKKIVKDLE HHHHHHHHHHHHHHH	50.13	7822465
280	Phosphorylation	IVKDLEASHQHSSPN HHHHHHHHHCCCCCC	17.82	30266825
284	Phosphorylation	LEASHQHSSPNEQLK HHHHHCCCCCCHHHC	40.70	30266825
285	Phosphorylation	EASHQHSSPNEQLKK HHHHCCCCCCHHHCC	29.62	30266825
312	Glutathionylation	LMLMSVFCQTESFPA EEEEEEHHCCCCCCC	4.60	22555962
329	Ubiquitination	THGSNIAKMTNTGLP CCCCCHHHHCCCCCC	42.32	23000965
340	Phosphorylation	TGLPGPATPAYSYAK CCCCCCCCCCCCHHH	16.16	21945579
343	Phosphorylation	PGPATPAYSYAKTNG CCCCCCCCCHHHHCC	11.92	21945579
344	Phosphorylation	GPATPAYSYAKTNGH CCCCCCCCHHHHCCC	22.26	21945579
345	Phosphorylation	PATPAYSYAKTNGHC CCCCCCCHHHHCCCC	10.23	21945579
429	Phosphorylation	SLTSSPCSSPVLTKR CCCCCCCCCCHHHHH	40.85	28348404
430	Phosphorylation	LTSSPCSSPVLTKRL CCCCCCCCCHHHHHH	26.24	28348404
440	Phosphorylation	LTKRLLGSSASSPGY HHHHHHCCCCCCCCC	23.77	21945579
441	Phosphorylation	TKRLLGSSASSPGYQ HHHHHCCCCCCCCCC	30.30	21945579
443	Phosphorylation	RLLGSSASSPGYQSS HHHCCCCCCCCCCCH	38.73	21945579
444	Phosphorylation	LLGSSASSPGYQSSY HHCCCCCCCCCCCHH	23.28	21945579
447	Phosphorylation	SSASSPGYQSSYQVG CCCCCCCCCCHHHHC	14.49	21945579
449	Phosphorylation	ASSPGYQSSYQVGIN CCCCCCCCHHHHCCH	23.64	21945579
450	Phosphorylation	SSPGYQSSYQVGINQ CCCCCCCHHHHCCHH	12.21	21945579
451	Phosphorylation	SPGYQSSYQVGINQR CCCCCCHHHHCCHHH	16.68	21945579
465	Methylation	RFHAARHKFQSQADQ HHHHHHHHHHHHCCH	39.27	-
468	Phosphorylation	AARHKFQSQADQDQQ HHHHHHHHHCCHHHH	30.39	25394399
477	Phosphorylation	ADQDQQASGLQSPPS CCHHHHHCCCCCCCC	35.38	22167270
481	Phosphorylation	QQASGLQSPPSRDLS HHHCCCCCCCCCCCC	43.77	19664994
484	Phosphorylation	SGLQSPPSRDLSPTL CCCCCCCCCCCCCHH	41.64	29255136
488	Phosphorylation	SPPSRDLSPTLIDNS CCCCCCCCCHHCCHH	21.81	19664994
490	Phosphorylation	PSRDLSPTLIDNSAA CCCCCCCHHCCHHHH	32.73	30266825
495	Phosphorylation	SPTLIDNSAAKQLAR CCHHCCHHHHHHHHH	26.34	30266825
498	Ubiquitination	LIDNSAAKQLARNTV HCCHHHHHHHHHHHH	45.63	23000965
504	Phosphorylation	AKQLARNTVTQVLSR HHHHHHHHHHHHHHH	21.27	28555341
510	Phosphorylation	NTVTQVLSRFTSQQG HHHHHHHHHHHCCCC	26.87	28555341
513	Phosphorylation	TQVLSRFTSQQGPIK HHHHHHHHCCCCCCC	25.23	23403867
514	Phosphorylation	QVLSRFTSQQGPIKP HHHHHHHCCCCCCCC	20.14	23403867
523	Phosphorylation	QGPIKPVSPNSSPFG CCCCCCCCCCCCCCC	27.22	25159151
526	Phosphorylation	IKPVSPNSSPFGTDY CCCCCCCCCCCCCCC	42.65	25159151
527	Phosphorylation	KPVSPNSSPFGTDYR CCCCCCCCCCCCCCH	30.78	25159151
531	Phosphorylation	PNSSPFGTDYRNLAN CCCCCCCCCCHHHCC	30.18	23663014
533	Phosphorylation	SSPFGTDYRNLANTA CCCCCCCCHHHCCCC	10.96	23403867
539	Phosphorylation	DYRNLANTANPRGDT CCHHHCCCCCCCCCC	23.39	23898821
546	Phosphorylation	TANPRGDTSHSPTPG CCCCCCCCCCCCCCC	31.03	30576142
547	Phosphorylation	ANPRGDTSHSPTPGK CCCCCCCCCCCCCCC	27.06	30242111
549	Phosphorylation	PRGDTSHSPTPGKVS CCCCCCCCCCCCCCC	30.18	26055452
551	Phosphorylation	GDTSHSPTPGKVSSP CCCCCCCCCCCCCCC	47.92	20068231
556	Phosphorylation	SPTPGKVSSPLSPLS CCCCCCCCCCCCCCC	29.71	30266825
557	Phosphorylation	PTPGKVSSPLSPLSP CCCCCCCCCCCCCCC	32.61	23927012
560	Phosphorylation	GKVSSPLSPLSPGIK CCCCCCCCCCCCCCC	27.46	29255136
563	Phosphorylation	SSPLSPLSPGIKSPT CCCCCCCCCCCCCCC	25.19	29255136
568	Phosphorylation	PLSPGIKSPTIPRAE CCCCCCCCCCCCHHH	25.92	29255136
570	Phosphorylation	SPGIKSPTIPRAERG CCCCCCCCCCHHHCC	51.18	29255136
590	Phosphorylation	PPKKPGLTPSPSATT CCCCCCCCCCCCCCC	27.86	25159151
592	Phosphorylation	KKPGLTPSPSATTPL CCCCCCCCCCCCCCC	26.67	25159151
594	Phosphorylation	PGLTPSPSATTPLTK CCCCCCCCCCCCCCC	42.45	21712546
596	Phosphorylation	LTPSPSATTPLTKTH CCCCCCCCCCCCCCH	33.03	25850435
597	Phosphorylation	TPSPSATTPLTKTHS CCCCCCCCCCCCCHH	18.93	25159151
600	Phosphorylation	PSATTPLTKTHSQAA CCCCCCCCCCHHHHC	34.79	22199227
602	Phosphorylation	ATTPLTKTHSQAASL CCCCCCCCHHHHCCC	22.86	28348404
604	Phosphorylation	TPLTKTHSQAASLTT CCCCCCHHHHCCCCC	27.09	28348404
608	Phosphorylation	KTHSQAASLTTAEDL CCHHHHCCCCCHHHH	29.30	29978859
610	Phosphorylation	HSQAASLTTAEDLAS HHHHCCCCCHHHHHH	22.82	29978859
611	Phosphorylation	SQAASLTTAEDLASS HHHCCCCCHHHHHHH	33.09	29978859
617	Phosphorylation	TTAEDLASSCSSNTV CCHHHHHHHCCCCEE	38.89	29978859
618	Phosphorylation	TAEDLASSCSSNTVV CHHHHHHHCCCCEEE	16.65	29978859
620	Phosphorylation	EDLASSCSSNTVVAN HHHHHHCCCCEEEEC	28.68	29978859
621	Phosphorylation	DLASSCSSNTVVANG HHHHHCCCCEEEECC	40.63	29978859
623	Phosphorylation	ASSCSSNTVVANGKD HHHCCCCEEEECCEE	20.50	29978859
637	Phosphorylation	DVELLLPTSS----- EEEEECCCCC-----	41.39	27251275
638	Phosphorylation	VELLLPTSS------ EEEECCCCC------	31.92	25627689
639	Phosphorylation	ELLLPTSS------- EEECCCCC-------	46.87	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
563	S	Phosphorylation	Kinase	CDK2	P24941	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CT2NL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CT2NL_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
2AAA_HUMAN	PPP2R1A	physical	18782753
PP2AA_HUMAN	PPP2CA	physical	18782753
STRN_HUMAN	STRN	physical	18782753
STRP1_HUMAN	STRIP1	physical	18782753
STRN3_HUMAN	STRN3	physical	18782753
2AAB_HUMAN	PPP2R1B	physical	18782753
STRN4_HUMAN	STRN4	physical	18782753
STK24_HUMAN	STK24	physical	18782753
PHOCN_HUMAN	MOB4	physical	18782753
PDC10_HUMAN	PDCD10	physical	18782753
STRP2_HUMAN	STRIP2	physical	18782753
STK26_HUMAN	STK26	physical	18782753
STK4_HUMAN	STK4	physical	24255178
STK3_HUMAN	STK3	physical	24255178
RUFY3_HUMAN	RUFY3	physical	24255178
CTTB2_HUMAN	CTTNBP2	physical	24255178
STRP1_HUMAN	STRIP1	physical	24255178
HDAC6_HUMAN	HDAC6	physical	24255178
PHOCN_HUMAN	MOB4	physical	24255178
NIPS1_HUMAN	NIPSNAP1	physical	24255178
OFD1_HUMAN	OFD1	physical	24255178
STRN_HUMAN	STRN	physical	24255178
STRN3_HUMAN	STRN3	physical	24255178
STRN4_HUMAN	STRN4	physical	24255178
ANR28_HUMAN	ANKRD28	physical	22863883
FLNC_HUMAN	FLNC	physical	22863883
USBP1_HUMAN	USHBP1	physical	25416956
STRN_HUMAN	STRN	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CT2NL_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-444; SER-481; SER-557;SER-560 AND SER-568, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-481; SER-484; SER-488;SER-523; SER-527; THR-590 AND SER-592, AND MASS SPECTROMETRY.	18669648 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-488, AND MASSSPECTROMETRY.	16964243 [Abstract]