NIPS1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NIPS1_HUMAN
• UniProt AC: Q9BPW8
• Protein Name: Protein NipSnap homolog 1
• Gene Name: NIPSNAP1
• Organism: Homo sapiens (Human).
• Sequence Length: 284
• Protein Sequence: MAPRLCSISVTARRLLGGPGPRAGDVASAAAARFYSKDNEGSWFRSLFVHKVDPRKDAHSTLLSKKETSNLYKIQFHNVKPEYLDAYNSLTEAVLPKLHLDEDYPCSLVGNWNTWYGEQDQAVHLWRFSGGYPALMDCMNKLKNNKEYLEFRRERSQMLLSRRNQLLLEFSFWNEPQPRMGPNIYELRTYKLKPGTMIEWGNNWARAIKYRQENQEAVGGFFSQIGELYVVHHLWAYKDLQSREETRNAAWRKRGWDENVYYTVPLVRHMESRIMIPLKISPLQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
37	Ubiquitination	AAARFYSKDNEGSWF HHHHHHCCCCCCCCE	53.87	-
51	Acetylation	FRSLFVHKVDPRKDA EEEEEEEECCCCCCH	42.93	19608861
51	Ubiquitination	FRSLFVHKVDPRKDA EEEEEEEECCCCCCH	42.93	21890473
56	Ubiquitination	VHKVDPRKDAHSTLL EEECCCCCCHHHHHC	65.73	-
60	Phosphorylation	DPRKDAHSTLLSKKE CCCCCHHHHHCCCHH	23.59	-
64	Phosphorylation	DAHSTLLSKKETSNL CHHHHHCCCHHCCCC	44.81	24719451
65	Acetylation	AHSTLLSKKETSNLY HHHHHCCCHHCCCCE	55.38	-
65	Ubiquitination	AHSTLLSKKETSNLY HHHHHCCCHHCCCCE	55.38	21890473
66	Acetylation	HSTLLSKKETSNLYK HHHHCCCHHCCCCEE	63.95	-
66	Ubiquitination	HSTLLSKKETSNLYK HHHHCCCHHCCCCEE	63.95	21890473
73	Acetylation	KETSNLYKIQFHNVK HHCCCCEEEEEECCC	32.95	-
80	Ubiquitination	KIQFHNVKPEYLDAY EEEEECCCHHHHHHH	37.13	-
80	Acetylation	KIQFHNVKPEYLDAY EEEEECCCHHHHHHH	37.13	-
83	Phosphorylation	FHNVKPEYLDAYNSL EECCCHHHHHHHHHH	20.57	-
87	Phosphorylation	KPEYLDAYNSLTEAV CHHHHHHHHHHHHHH	12.64	-
89	Phosphorylation	EYLDAYNSLTEAVLP HHHHHHHHHHHHHHH	24.80	20166139
91	Phosphorylation	LDAYNSLTEAVLPKL HHHHHHHHHHHHHHC	23.01	28348404
107	Phosphorylation	LDEDYPCSLVGNWNT CCCCCCCCEECCCCC	22.91	-
129	Phosphorylation	AVHLWRFSGGYPALM HEEEEEECCCHHHHH	23.80	28857561
141	Acetylation	ALMDCMNKLKNNKEY HHHHHHHHHHCCHHH	33.67	25953088
143	Malonylation	MDCMNKLKNNKEYLE HHHHHHHHCCHHHHH	61.15	26320211
143	Acetylation	MDCMNKLKNNKEYLE HHHHHHHHCCHHHHH	61.15	25953088
146	Succinylation	MNKLKNNKEYLEFRR HHHHHCCHHHHHHHH	58.07	23954790
146	Succinylation	MNKLKNNKEYLEFRR HHHHHCCHHHHHHHH	58.07	-
146	Acetylation	MNKLKNNKEYLEFRR HHHHHCCHHHHHHHH	58.07	19608861
146	Malonylation	MNKLKNNKEYLEFRR HHHHHCCHHHHHHHH	58.07	26320211
148	Phosphorylation	KLKNNKEYLEFRRER HHHCCHHHHHHHHHH	17.09	25839225
156	Phosphorylation	LEFRRERSQMLLSRR HHHHHHHHHHHHHHH	18.39	29978859
161	Phosphorylation	ERSQMLLSRRNQLLL HHHHHHHHHHHCHHH	25.82	29978859
180	Sulfoxidation	WNEPQPRMGPNIYEL CCCCCCCCCCCEEEE	15.48	21406390
185	Phosphorylation	PRMGPNIYELRTYKL CCCCCCEEEEEEEEC	18.62	20068231
188	Methylation	GPNIYELRTYKLKPG CCCEEEEEEEECCCC	24.86	115485041
191	Acetylation	IYELRTYKLKPGTMI EEEEEEEECCCCCEE	49.80	25953088
193	Succinylation	ELRTYKLKPGTMIEW EEEEEECCCCCEEEE	36.93	-
193	Succinylation	ELRTYKLKPGTMIEW EEEEEECCCCCEEEE	36.93	21890473
193	Acetylation	ELRTYKLKPGTMIEW EEEEEECCCCCEEEE	36.93	-
193	Ubiquitination	ELRTYKLKPGTMIEW EEEEEECCCCCEEEE	36.93	21890473
253	Ubiquitination	TRNAAWRKRGWDENV HHHHHHHHCCCCCCC	44.56	21890473
254	Methylation	RNAAWRKRGWDENVY HHHHHHHCCCCCCCE	42.75	115485049
261	Phosphorylation	RGWDENVYYTVPLVR CCCCCCCEEEHHHEE	12.66	28152594
262	Phosphorylation	GWDENVYYTVPLVRH CCCCCCEEEHHHEEE	9.29	28152594
263	Phosphorylation	WDENVYYTVPLVRHM CCCCCEEEHHHEEEC	9.65	28152594
279	Succinylation	SRIMIPLKISPLQ-- CEEEEEEEECCCC--	35.46	23954790
279	Acetylation	SRIMIPLKISPLQ-- CEEEEEEEECCCC--	35.46	25953088
279	Ubiquitination	SRIMIPLKISPLQ-- CEEEEEEEECCCC--	35.46	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NIPS1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NIPS1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NIPS1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ACBP_HUMAN	DBI	physical	21900206
TCPZ_HUMAN	CCT6A	physical	26496610
FAT1_HUMAN	FAT1	physical	26496610
CH60_HUMAN	HSPD1	physical	26496610
PLEC_HUMAN	PLEC	physical	26496610
AAPK2_HUMAN	PRKAA2	physical	26496610
TCF20_HUMAN	TCF20	physical	26496610
TCPA_HUMAN	TCP1	physical	26496610
TCPG_HUMAN	CCT3	physical	26496610
BCL7B_HUMAN	BCL7B	physical	26496610
TF3C5_HUMAN	GTF3C5	physical	26496610
KNTC1_HUMAN	KNTC1	physical	26496610
TCPH_HUMAN	CCT7	physical	26496610
TCPD_HUMAN	CCT4	physical	26496610
TCPB_HUMAN	CCT2	physical	26496610
NS1BP_HUMAN	IVNS1ABP	physical	26496610
TCPQ_HUMAN	CCT8	physical	26496610
HPSE_HUMAN	HPSE	physical	26496610
POP1_HUMAN	POP1	physical	26496610
FND3A_HUMAN	FNDC3A	physical	26496610
TCPE_HUMAN	CCT5	physical	26496610
GANAB_HUMAN	GANAB	physical	26496610
ARHGC_HUMAN	ARHGEF12	physical	26496610
ZN281_HUMAN	ZNF281	physical	26496610
LCOR_HUMAN	C10orf12	physical	26496610
HP1B3_HUMAN	HP1BP3	physical	26496610
HAUS6_HUMAN	HAUS6	physical	26496610
RT18A_HUMAN	MRPS18A	physical	26496610
ASCC2_HUMAN	ASCC2	physical	26496610
TNC18_HUMAN	TNRC18	physical	26496610
DJC21_HUMAN	DNAJC21	physical	26496610
NSE2_HUMAN	NSMCE2	physical	26496610
IF140_HUMAN	IFT140	physical	27173435
WDR19_HUMAN	WDR19	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-51 AND LYS-146, AND MASSSPECTROMETRY.
PubMed: 19608861