KNTC1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KNTC1_HUMAN
• UniProt AC: P50748
• Protein Name: Kinetochore-associated protein 1
• Gene Name: KNTC1
• Organism: Homo sapiens (Human).
• Sequence Length: 2209
• Subcellular Localization: Cytoplasm. Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Dynamic pattern of localization during the cell cycle. At interphase, uniformly distributed throughout the cytoplasm and nucleus. By prophase and until late st
• Protein Description: Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. [PubMed: 11146660]
• Protein Sequence: MWNDIELLTNDDTGSGYLSVGSRKEHGTALYQVDLLVKISSEKASLNPKIQACSLSDGFIIVADQSVILLDSICRSLQLHLVFDTEVDVVGLCQEGKFLLVGERSGNLHLIHVTSKQTLLTNAFVQKANDENRRTYQNLVIEKDGSNEGTYYMLLLTYSGFFCITNLQLLKIQQAIENVDFSTAKKLQGQIKSSFISTENYHTLGCLSLVAGDLASEVPVIIGGTGNCAFSKWEPDSSKKGMTVKNLIDAEIIKGAKKFQLIDNLLFVLDTDNVLSLWDIYTLTPVWNWPSLHVEEFLLTTEADSPSSVTWQGITNLKLIALTASANKKMKNLMVYSLPTMEILYSLEVSSVSSLVQTGISTDTIYLLEGVCKNDPKLSEDSVSVLVLRCLTEALPENRLSRLLHKHRFAEAESFAIQFGLDVELVYKVKSNHILEKLALSSVDASEQTEWQQLVDDAKENLHKIQDDEFVVNYCLKAQWITYETTQEMLNYAKTRLLKKEDKTALIYSDGLKEVLRAHAKLTTFYGAFGPEKFSGSSWIEFLNNEDDLKDIFLQLKEGNLVCAQYLWLRHRANFESRFDVKMLESLLNSMSASVSLQKLCPWFKNDVIPFVRRTVPEGQIILAKWLEQAARNLELTDKANWPENGLQLAEIFFTAEKTDELGLASSWHWISLKDYQNTEEVCQLRTLVNNLRELITLHRKYNCKLALSDFEKENTTTIVFRMFDKVLAPELIPSILEKFIRVYMREHDLQEEELLLLYIEDLLNRCSSKSTSLFETAWEAKAMAVIACLSDTDLIFDAVLKIMYAAVVPWSAAVEQLVKQHLEMDHPKVKLLQESYKLMEMKKLLRGYGIREVNLLNKEIMRVVRYILKQDVPSSLEDALKVAQAFMLSDDEIYSLRIIDLIDREQGEDCLLLLKSLPPAEAEKTAERVIIWARLALQEEPDHSKEGKAWRMSVAKTSVDILKILCDIQKDNLQKKDECEEMLKLFKEVASLQENFEVFLSFEDYSNSSLVADLREQHIKAHEVAQAKHKPGSTPEPIAAEVRSPSMESKLHRQALALQMSKQELEAELTLRALKDGNIKTALKKCSDLFKYHCNADTGKLLFLTCQKLCQMLADNVPVTVPVGLNLPSMIHDLASQAATICSPDFLLDALELCKHTLMAVELSRQCQMDDCGILMKASFGTHKDPYEEWSYSDFFSEDGIVLESQMVLPVIYELISSLVPLAESKRYPLESTSLPYCSLNEGDGLVLPVINSISALLQNLQESSQWELALRFVVGSFGTCLQHSVSNFMNATLSEKLFGETTLVKSRHVVMELKEKAVIFIRENATTLLHKVFNCRLVDLDLALGYCTLLPQKDVFENLWKLIDKAWQNYDKILAISLVGSELASLYQEIEMGLKFRELSTDAQWGIRLGKLGISFQPVFRQHFLTKKDLIKALVENIDMDTSLILEYCSTFQLDCDAVLQLFIETLLHNTNAGQGQGDASMDSAKRRHPKLLAKALEMVPLLTSTKDLVISLSGILHKLDPYDYEMIEVVLKVIERADEKITNININQALSILKHLKSYRRISPPVDLEYQYMLEHVITLPSAAQTRLPFHLIFFGTAQNFWKILSTELSEESFPTLLLISKLMKFSLDTLYVSTAKHVFEKKLKPKLLKLTQAKSSTLINKEITKITQTIESCLLSIVNPEWAVAIAISLAQDIPEGSFKISALKFCLYLAERWLQNIPSQDEKREKAEALLKKLHIQYRRSGTEAVLIAHKLNTEEYLRVIGKPAHLIVSLYEHPSINQRIQNSSGTDYPDIHAAAKEIAEVNEINLEKVWDMLLEKWLCPSTKPGEKPSELFELQEDEALRRVQYLLLSRPIDYSSRMLFVFATSTTTTLGMHQLTFAHRTRALQCLFYLADKETIESLFKKPIEEVKSYLRCITFLASFETLNIPITYELFCSSPKEGMIKGLWKNHSHESMAVRLVTELCLEYKIYDLQLWNGLLQKLLGFNMIPYLRKVLKAISSIHSLWQVPYFSKAWQRVIQIPLLSASCPLSPDQLSDCSESLIAVLECPVSGDLDLIGVARQYIQLELPAFALACLMLMPHSEKRHQQIKNFLGSCDPQVILKQLEEHMNTGQLAGFSHQIRSLILNNIINKKEFGILAKTKYFQMLKMHAMNTNNITELVNYLANDLSLDEASVLITEYSKHCGKPVPPDTAPCEILKMFLSGLS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	WNDIELLTNDDTGSG CCCEEEECCCCCCCC	49.58	23401153
13	Phosphorylation	ELLTNDDTGSGYLSV EEECCCCCCCCEEEC	35.79	23401153
15	Phosphorylation	LTNDDTGSGYLSVGS ECCCCCCCCEEECCC	26.76	25159151
17	Phosphorylation	NDDTGSGYLSVGSRK CCCCCCCEEECCCCC	9.48	27642862
19	Phosphorylation	DTGSGYLSVGSRKEH CCCCCEEECCCCCCC	18.89	23401153
23	Ubiquitination	GYLSVGSRKEHGTAL CEEECCCCCCCCEEE	42.31	21963094
28	Phosphorylation	GSRKEHGTALYQVDL CCCCCCCEEEEEEEE	18.52	20860994
33	Ubiquitination	HGTALYQVDLLVKIS CCEEEEEEEEEEEEC	3.37	22817900
34	Ubiquitination	GTALYQVDLLVKISS CEEEEEEEEEEEECC	20.82	22817900
38	Ubiquitination	YQVDLLVKISSEKAS EEEEEEEEECCCCCC	36.52	22817900
43	Ubiquitination	LVKISSEKASLNPKI EEEECCCCCCCCCCC	45.27	21906983
49	Ubiquitination	EKASLNPKIQACSLS CCCCCCCCCCEEECC	46.51	23503661
78	Ubiquitination	DSICRSLQLHLVFDT HHHHHHCCCHHHCCC	28.25	-
83	Ubiquitination	SLQLHLVFDTEVDVV HCCCHHHCCCCCCEE	13.98	21906983
87	Ubiquitination	HLVFDTEVDVVGLCQ HHHCCCCCCEEEEEC	8.00	27667366
90	Ubiquitination	FDTEVDVVGLCQEGK CCCCCCEEEEECCCC	4.13	21906983
127	Ubiquitination	LTNAFVQKANDENRR HHHHHHHHCCCCCCC	43.80	29967540
131	Ubiquitination	FVQKANDENRRTYQN HHHHCCCCCCCEEEE	53.06	22817900
144	Ubiquitination	QNLVIEKDGSNEGTY EEEEEEECCCCCCEE	53.62	22817900
156	Ubiquitination	GTYYMLLLTYSGFFC CEEEEEEEEECCEEE	3.58	21906983
157	Ubiquitination	TYYMLLLTYSGFFCI EEEEEEEEECCEEEE	18.66	23503661
176	Ubiquitination	LLKIQQAIENVDFST HHHHHHHHHCCCHHH	3.26	27667366
185	Ubiquitination	NVDFSTAKKLQGQIK CCCHHHHHHHHHHHH	54.85	21906983
186	Ubiquitination	VDFSTAKKLQGQIKS CCHHHHHHHHHHHHH	43.51	22817900
203	Phosphorylation	ISTENYHTLGCLSLV ECCCCCCHHHHHHHH	17.93	24719451
227	Ubiquitination	VIIGGTGNCAFSKWE EEECCCCCCCCCCCC	17.49	21906983
239	Ubiquitination	KWEPDSSKKGMTVKN CCCCCCCCCCCCHHH	58.25	27667366
254	Ubiquitination	LIDAEIIKGAKKFQL HHCHHHHCCCCHHCE	59.48	-
285	Ubiquitination	WDIYTLTPVWNWPSL HHHHCCCCCCCCCCC	32.04	22817900
288	Ubiquitination	YTLTPVWNWPSLHVE HCCCCCCCCCCCCEE	40.80	22817900
307	Ubiquitination	TTEADSPSSVTWQGI CCCCCCCCCCCEECC	41.20	22817900
312	Ubiquitination	SPSSVTWQGITNLKL CCCCCCEECCCCHHH	24.84	22817900
323	Phosphorylation	NLKLIALTASANKKM CHHHEEEECCCCHHH	15.00	24114839
325	Phosphorylation	KLIALTASANKKMKN HHEEEECCCCHHHCC	27.43	-
328	Ubiquitination	ALTASANKKMKNLMV EEECCCCHHHCCEEE	54.70	27667366
342	Ubiquitination	VYSLPTMEILYSLEV EEECCCHHHHHEEEC	32.11	22817900
347	Ubiquitination	TMEILYSLEVSSVSS CHHHHHEEECCCHHH	4.81	22817900
348	Ubiquitination	MEILYSLEVSSVSSL HHHHHEEECCCHHHH	34.12	23503661
361	Ubiquitination	SLVQTGISTDTIYLL HHHHCCCCCCHHHEE	22.90	22817900
364	Ubiquitination	QTGISTDTIYLLEGV HCCCCCCHHHEEEHH	16.17	27667366
377	Ubiquitination	GVCKNDPKLSEDSVS HHHCCCCCCCHHHHH	68.46	29967540
430	Ubiquitination	VELVYKVKSNHILEK EEEEEEECCCHHHHH	41.19	29967540
437	Ubiquitination	KSNHILEKLALSSVD CCCHHHHHHHHHCCC	35.30	21906983
441	Phosphorylation	ILEKLALSSVDASEQ HHHHHHHHCCCCCHH	23.78	22817900
442	Phosphorylation	LEKLALSSVDASEQT HHHHHHHCCCCCHHH	25.51	22817900
446	Phosphorylation	ALSSVDASEQTEWQQ HHHCCCCCHHHHHHH	26.27	22817900
447	Ubiquitination	LSSVDASEQTEWQQL HHCCCCCHHHHHHHH	64.34	21963094
449	Ubiquitination	SVDASEQTEWQQLVD CCCCCHHHHHHHHHH	34.83	22817900
453	Ubiquitination	SEQTEWQQLVDDAKE CHHHHHHHHHHHHHH	44.52	21963094
459	Ubiquitination	QQLVDDAKENLHKIQ HHHHHHHHHHHHHCC	54.88	21906983
464	Ubiquitination	DAKENLHKIQDDEFV HHHHHHHHCCCCHHH	45.27	22817900
473	Ubiquitination	QDDEFVVNYCLKAQW CCCHHHHHHHHHEEE	19.25	21890473
494	Ubiquitination	QEMLNYAKTRLLKKE HHHHHHHHHHHCCCC	24.66	21906983
495	Phosphorylation	EMLNYAKTRLLKKED HHHHHHHHHHCCCCC	20.55	21406692
499	Ubiquitination	YAKTRLLKKEDKTAL HHHHHHCCCCCCEEE	59.72	22817900
500	Ubiquitination	AKTRLLKKEDKTALI HHHHHCCCCCCEEEE	71.73	23503661
503	Ubiquitination	RLLKKEDKTALIYSD HHCCCCCCEEEEECC	36.47	29967540
513	Ubiquitination	LIYSDGLKEVLRAHA EEECCCHHHHHHHHH	51.83	21906983
521	Ubiquitination	EVLRAHAKLTTFYGA HHHHHHHHHHHCCCC	36.18	29967540
535	Phosphorylation	AFGPEKFSGSSWIEF CCCCCCCCCCCHHHH	49.16	18452278
561	Ubiquitination	LQLKEGNLVCAQYLW HHHHHCCEEEEEHHH	5.01	22817900
574	Ubiquitination	LWLRHRANFESRFDV HHHHHHCCCCCCCCH	40.97	22817900
587	Ubiquitination	DVKMLESLLNSMSAS CHHHHHHHHHHCCCC	3.71	23503661
590	Phosphorylation	MLESLLNSMSASVSL HHHHHHHHCCCCHHH	17.68	23401153
605	Ubiquitination	QKLCPWFKNDVIPFV HHHCHHHHCCCHHHH	48.66	21963094
625	Ubiquitination	EGQIILAKWLEQAAR CHHHHHHHHHHHHHH	49.19	21906983
705	Ubiquitination	LHRKYNCKLALSDFE HHHHHCCEEEHHHCC	32.91	29967540
709	Phosphorylation	YNCKLALSDFEKENT HCCEEEHHHCCCCCC	34.35	-
713	Ubiquitination	LALSDFEKENTTTIV EEHHHCCCCCCEEEE	57.15	21906983
717	Phosphorylation	DFEKENTTTIVFRMF HCCCCCCEEEEEEEC	26.55	28509920
718	Phosphorylation	FEKENTTTIVFRMFD CCCCCCEEEEEEECC	17.07	28509920
718	Ubiquitination	FEKENTTTIVFRMFD CCCCCCEEEEEEECC	17.07	22817900
725	Ubiquitination	TIVFRMFDKVLAPEL EEEEEECCHHHCHHH	30.70	22817900
726	Acetylation	IVFRMFDKVLAPELI EEEEECCHHHCHHHH	28.08	23236377
726	Ubiquitination	IVFRMFDKVLAPELI EEEEECCHHHCHHHH	28.08	22817900
735	Phosphorylation	LAPELIPSILEKFIR HCHHHHHHHHHHHHH	32.58	24719451
739	Ubiquitination	LIPSILEKFIRVYMR HHHHHHHHHHHHHHH	42.52	33845483
769	Phosphorylation	DLLNRCSSKSTSLFE HHHHHCCCCCCCHHH	33.96	-
785	Ubiquitination	AWEAKAMAVIACLSD HHHHHHHHHHHHCCC	8.40	27667366
794	Ubiquitination	IACLSDTDLIFDAVL HHHCCCHHHHHHHHH	42.64	27667366
829	Ubiquitination	HLEMDHPKVKLLQES HHCCCCHHHHHHHHH	48.89	29967540
831	Ubiquitination	EMDHPKVKLLQESYK CCCCHHHHHHHHHHH	50.00	21963094
838	Ubiquitination	KLLQESYKLMEMKKL HHHHHHHHHHHHHHH	51.11	32015554
849	Phosphorylation	MKKLLRGYGIREVNL HHHHHHCCCCHHHHC	11.71	-
859	Acetylation	REVNLLNKEIMRVVR HHHHCCCHHHHHHHH	48.89	23236377
859	Ubiquitination	REVNLLNKEIMRVVR HHHHCCCHHHHHHHH	48.89	-
867	Phosphorylation	EIMRVVRYILKQDVP HHHHHHHHHHHCCCC	10.05	-
870	Ubiquitination	RVVRYILKQDVPSSL HHHHHHHHCCCCCCH	34.59	21906983
877	Ubiquitination	KQDVPSSLEDALKVA HCCCCCCHHHHHHHH	8.95	21963094
879	Ubiquitination	DVPSSLEDALKVAQA CCCCCHHHHHHHHHH	63.59	22817900
896	Phosphorylation	LSDDEIYSLRIIDLI CCCCCEEEEEEEECC	19.48	24719451
911	Ubiquitination	DREQGEDCLLLLKSL CHHCCCCEEEHHHCC	2.22	22817900
915	Ubiquitination	GEDCLLLLKSLPPAE CCCEEEHHHCCCHHH	3.41	22817900
916	Ubiquitination	EDCLLLLKSLPPAEA CCEEEHHHCCCHHHH	50.33	29967540
929	Ubiquitination	EAEKTAERVIIWARL HHHHHHHHHHHHHHH	23.59	27667366
946	Ubiquitination	QEEPDHSKEGKAWRM HCCCCCCCCCHHHHH	68.04	27667366
957	Ubiquitination	AWRMSVAKTSVDILK HHHHHHHHHHHHHHH	38.89	-
971	Ubiquitination	KILCDIQKDNLQKKD HHHHHHHHHCCCCHH	49.25	29967540
975	Ubiquitination	DIQKDNLQKKDECEE HHHHHCCCCHHHHHH	57.94	22817900
976	Ubiquitination	IQKDNLQKKDECEEM HHHHCCCCHHHHHHH	66.41	-
978	Ubiquitination	KDNLQKKDECEEMLK HHCCCCHHHHHHHHH	73.20	22817900
985	Ubiquitination	DECEEMLKLFKEVAS HHHHHHHHHHHHHHH	51.04	29967540
1021	Ubiquitination	DLREQHIKAHEVAQA HHHHHHHHHHHHHHH	41.38	29967540
1029	Ubiquitination	AHEVAQAKHKPGSTP HHHHHHHCCCCCCCC	39.83	21963094
1031	Ubiquitination	EVAQAKHKPGSTPEP HHHHHCCCCCCCCCC	50.82	21906983
1034	Phosphorylation	QAKHKPGSTPEPIAA HHCCCCCCCCCCHHH	49.68	23927012
1035	Phosphorylation	AKHKPGSTPEPIAAE HCCCCCCCCCCHHHH	37.27	25159151
1045	Phosphorylation	PIAAEVRSPSMESKL CHHHHCCCCCHHHHH	26.88	25159151
1047	Phosphorylation	AAEVRSPSMESKLHR HHHCCCCCHHHHHHH	36.11	29116813
1050	Phosphorylation	VRSPSMESKLHRQAL CCCCCHHHHHHHHHH	31.69	23927012
1051	Ubiquitination	RSPSMESKLHRQALA CCCCHHHHHHHHHHH	34.70	29967540
1071	Phosphorylation	QELEAELTLRALKDG HHHHHHHHHHHHHCC	13.00	20860994
1071	Ubiquitination	QELEAELTLRALKDG HHHHHHHHHHHHHCC	13.00	22817900
1076	Acetylation	ELTLRALKDGNIKTA HHHHHHHHCCCHHHH	63.71	7380667
1076	Ubiquitination	ELTLRALKDGNIKTA HHHHHHHHCCCHHHH	63.71	22817900
1081	Acetylation	ALKDGNIKTALKKCS HHHCCCHHHHHHHHH	31.57	7380677
1081	Ubiquitination	ALKDGNIKTALKKCS HHHCCCHHHHHHHHH	31.57	27667366
1083	Ubiquitination	KDGNIKTALKKCSDL HCCCHHHHHHHHHHH	16.63	22817900
1085	Acetylation	GNIKTALKKCSDLFK CCHHHHHHHHHHHHH	49.63	7380687
1086	Ubiquitination	NIKTALKKCSDLFKY CHHHHHHHHHHHHHH	39.56	29967540
1087	Ubiquitination	IKTALKKCSDLFKYH HHHHHHHHHHHHHHH	3.51	22817900
1092	Acetylation	KKCSDLFKYHCNADT HHHHHHHHHHCCCCC	41.19	25953088
1146	Ubiquitination	AATICSPDFLLDALE HHHHCCHHHHHHHHH	30.45	22817900
1149	Ubiquitination	ICSPDFLLDALELCK HCCHHHHHHHHHHHH	3.50	22817900
1155	Ubiquitination	LLDALELCKHTLMAV HHHHHHHHHHHHHHH	1.90	22817900
1215	Ubiquitination	MVLPVIYELISSLVP CHHHHHHHHHHHHHH	28.62	27667366
1220	Ubiquitination	IYELISSLVPLAESK HHHHHHHHHHHHHCC	3.52	22817900
1261	Ubiquitination	SISALLQNLQESSQW HHHHHHHHHHHHCCH	43.60	21963094
1307	Ubiquitination	FGETTLVKSRHVVME HCCCEEEECCCEEEE	44.90	21906983
1316	Acetylation	RHVVMELKEKAVIFI CCEEEEEHHCEEEEE	43.81	19608861
1341	Ubiquitination	VFNCRLVDLDLALGY HHCCCCCCHHHHCCH	38.77	22817900
1345	Ubiquitination	RLVDLDLALGYCTLL CCCCHHHHCCHHCCC	9.90	22817900
1367	Ubiquitination	NLWKLIDKAWQNYDK HHHHHHHHHHHCHHH	44.52	27667366
1379	Phosphorylation	YDKILAISLVGSELA HHHHHHHHHHHHHHH	16.05	-
1389	Phosphorylation	GSELASLYQEIEMGL HHHHHHHHHHHHHCC	11.12	-
1405	Ubiquitination	FRELSTDAQWGIRLG HHHCCCCCCHHHHHH	13.71	22817900
1408	Ubiquitination	LSTDAQWGIRLGKLG CCCCCCHHHHHHCCC	5.31	22817900
1413	Ubiquitination	QWGIRLGKLGISFQP CHHHHHHCCCCCCCH	48.40	21906983
1428	Phosphorylation	VFRQHFLTKKDLIKA HHHHHCCCHHHHHHH	34.79	-
1493	Ubiquitination	SAKRRHPKLLAKALE HHHHHCHHHHHHHHH	50.43	22817900
1497	Ubiquitination	RHPKLLAKALEMVPL HCHHHHHHHHHHHHH	54.17	21906983
1501	Ubiquitination	LLAKALEMVPLLTST HHHHHHHHHHHCCCC	3.80	22817900
1506	Ubiquitination	LEMVPLLTSTKDLVI HHHHHHCCCCHHHHH	41.87	22817900
1513	Ubiquitination	TSTKDLVISLSGILH CCCHHHHHHHHHHHH	4.45	22817900
1517	Ubiquitination	DLVISLSGILHKLDP HHHHHHHHHHHHCCC	31.60	22817900
1527	Ubiquitination	HKLDPYDYEMIEVVL HHCCCCCHHHHHHHH	11.10	22817900
1530	Ubiquitination	DPYDYEMIEVVLKVI CCCCHHHHHHHHHHH	2.13	22817900
1543	Ubiquitination	VIERADEKITNININ HHHHCCHHHCCCCHH	56.21	29967540
1545	Phosphorylation	ERADEKITNININQA HHCCHHHCCCCHHHH	40.91	20068231
1553	Ubiquitination	NININQALSILKHLK CCCHHHHHHHHHHHH	2.05	27667366
1554	Phosphorylation	ININQALSILKHLKS CCHHHHHHHHHHHHH	28.96	24719451
1557	Ubiquitination	NQALSILKHLKSYRR HHHHHHHHHHHHHCC	45.26	21906983
1560	Ubiquitination	LSILKHLKSYRRISP HHHHHHHHHHCCCCC	45.20	22817900
1563	Ubiquitination	LKHLKSYRRISPPVD HHHHHHHCCCCCCCC	36.23	27667366
1576	Ubiquitination	VDLEYQYMLEHVITL CCHHHHHHHHHHCCC	1.77	22817900
1579	Ubiquitination	EYQYMLEHVITLPSA HHHHHHHHHCCCCCH	16.59	22817900
1609	Phosphorylation	QNFWKILSTELSEES HHHHHHHCHHCCCCC	24.25	30576142
1610	Phosphorylation	NFWKILSTELSEESF HHHHHHCHHCCCCCH	37.18	30576142
1613	Phosphorylation	KILSTELSEESFPTL HHHCHHCCCCCHHHH	32.84	30576142
1623	Ubiquitination	SFPTLLLISKLMKFS CHHHHHHHHHHHCCC	3.26	22817900
1628	Ubiquitination	LLISKLMKFSLDTLY HHHHHHHCCCCCHHC	42.09	22817900
1630	Phosphorylation	ISKLMKFSLDTLYVS HHHHHCCCCCHHCHH	21.59	-
1633	Phosphorylation	LMKFSLDTLYVSTAK HHCCCCCHHCHHCHH	25.86	-
1635	Phosphorylation	KFSLDTLYVSTAKHV CCCCCHHCHHCHHHH	8.41	-
1635	Ubiquitination	KFSLDTLYVSTAKHV CCCCCHHCHHCHHHH	8.41	22817900
1639	Ubiquitination	DTLYVSTAKHVFEKK CHHCHHCHHHHHHHC	7.76	22817900
1650	Ubiquitination	FEKKLKPKLLKLTQA HHHCCCHHHHHHHHC	65.94	22817900
1653	Ubiquitination	KLKPKLLKLTQAKSS CCCHHHHHHHHCCHH	60.98	22817900
1655	Phosphorylation	KPKLLKLTQAKSSTL CHHHHHHHHCCHHHH	25.54	-
1658	Ubiquitination	LLKLTQAKSSTLINK HHHHHHCCHHHHCCH	34.81	21906983
1660	Phosphorylation	KLTQAKSSTLINKEI HHHHCCHHHHCCHHH	26.90	-
1661	Phosphorylation	LTQAKSSTLINKEIT HHHCCHHHHCCHHHH	38.45	-
1665	Ubiquitination	KSSTLINKEITKITQ CHHHHCCHHHHHHHH	43.42	21906983
1669	Ubiquitination	LINKEITKITQTIES HCCHHHHHHHHHHHH	49.79	22817900
1698	Ubiquitination	AISLAQDIPEGSFKI HHHHHCCCCCCCHHH	1.91	22817900
1701	Ubiquitination	LAQDIPEGSFKISAL HHCCCCCCCHHHHHH	32.78	22817900
1728	Ubiquitination	NIPSQDEKREKAEAL CCCCCHHHHHHHHHH	74.31	22817900
1731	Ubiquitination	SQDEKREKAEALLKK CCHHHHHHHHHHHHH	56.40	21906983
1738	Ubiquitination	KAEALLKKLHIQYRR HHHHHHHHHCHHHHC	45.31	29967540
1746	Phosphorylation	LHIQYRRSGTEAVLI HCHHHHCCCCCEEEE	40.86	20860994
1748	Phosphorylation	IQYRRSGTEAVLIAH HHHHCCCCCEEEEEE	23.24	20860994
1762	Phosphorylation	HKLNTEEYLRVIGKP EECCHHHHHHHHCCC	8.12	25587033
1772	Ubiquitination	VIGKPAHLIVSLYEH HHCCCHHEEEEHHCC	4.49	22817900
1775	Phosphorylation	KPAHLIVSLYEHPSI CCHHEEEEHHCCCCH	20.45	20068231
1777	Phosphorylation	AHLIVSLYEHPSINQ HHEEEEHHCCCCHHH	12.51	20068231
1781	Phosphorylation	VSLYEHPSINQRIQN EEHHCCCCHHHHHHC	35.76	20068231
1802	Ubiquitination	PDIHAAAKEIAEVNE HHHHHHHHHHHHHHC	44.95	22817900
1904	Phosphorylation	ADKETIESLFKKPIE CCHHHHHHHHCCCHH	34.94	24719451
1955	Phosphorylation	KGLWKNHSHESMAVR CCHHHCCCCHHHHHH	38.04	-
1974	Phosphorylation	LCLEYKIYDLQLWNG HHHHCHHHCHHHHHH	13.37	-
1983	Ubiquitination	LQLWNGLLQKLLGFN HHHHHHHHHHHHCCC	4.47	27667366
1993	Ubiquitination	LLGFNMIPYLRKVLK HHCCCHHHHHHHHHH	16.01	27667366
1994	Phosphorylation	LGFNMIPYLRKVLKA HCCCHHHHHHHHHHH	14.28	20068231
2066	Phosphorylation	LIGVARQYIQLELPA HHHHHHHHHHCHHHH	5.77	24043423
2085	Phosphorylation	CLMLMPHSEKRHQQI HHHHCCCCHHHHHHH	38.65	24043423
2093	Ubiquitination	EKRHQQIKNFLGSCD HHHHHHHHHHHHCCC	36.99	29967540
2098	Phosphorylation	QIKNFLGSCDPQVIL HHHHHHHCCCHHHHH	19.93	17924679
2105	Ubiquitination	SCDPQVILKQLEEHM CCCHHHHHHHHHHHC	2.80	27667366
2109	Ubiquitination	QVILKQLEEHMNTGQ HHHHHHHHHHCCCCH	43.28	27667366
2115	Ubiquitination	LEEHMNTGQLAGFSH HHHHCCCCHHCCHHH	18.59	27667366
2119	Ubiquitination	MNTGQLAGFSHQIRS CCCCHHCCHHHHHHH	32.93	27667366
2135	Ubiquitination	ILNNIINKKEFGILA HHHHCCCHHHCCHHC	43.18	27667366
2136	Ubiquitination	LNNIINKKEFGILAK HHHCCCHHHCCHHCH	54.51	29967540
2145	Ubiquitination	FGILAKTKYFQMLKM CCHHCHHHHHHHHHH	43.28	27667366
2157	Phosphorylation	LKMHAMNTNNITELV HHHHHCCCCCHHHHH	19.29	25002506
2161	Phosphorylation	AMNTNNITELVNYLA HCCCCCHHHHHHHHH	25.95	25002506
2166	Phosphorylation	NITELVNYLANDLSL CHHHHHHHHHHCCCC	10.34	25002506
2172	Phosphorylation	NYLANDLSLDEASVL HHHHHCCCCCHHHHH	36.32	25002506
2177	Phosphorylation	DLSLDEASVLITEYS CCCCCHHHHHHHHHH	18.53	25002506
2181	Phosphorylation	DEASVLITEYSKHCG CHHHHHHHHHHHHCC	25.39	25002506
2183	Phosphorylation	ASVLITEYSKHCGKP HHHHHHHHHHHCCCC	17.86	25002506
2184	Phosphorylation	SVLITEYSKHCGKPV HHHHHHHHHHCCCCC	15.08	25002506
2202	Ubiquitination	TAPCEILKMFLSGLS CCCHHHHHHHHHCCC	33.01	32015554

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KNTC1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KNTC1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KNTC1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ZW10_HUMAN	ZW10	physical	11146660
PIAS4_HUMAN	PIAS4	physical	20696768
ZW10_HUMAN	ZW10	physical	20696768
ZW10_HUMAN	ZW10	physical	22939629

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-441; SER-442 ANDSER-446, AND MASS SPECTROMETRY.
PubMed: 19690332

"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
J. Proteome Res. 6:4150-4162(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2098, AND MASSSPECTROMETRY.
PubMed: 17924679