ZW10_HUMAN - dbPTM
ZW10_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ZW10_HUMAN
UniProt AC O43264
Protein Name Centromere/kinetochore protein zw10 homolog
Gene Name ZW10
Organism Homo sapiens (Human).
Sequence Length 779
Subcellular Localization Cytoplasm . Endoplasmic reticulum membrane
Peripheral membrane protein . Chromosome, centromere, kinetochore . Cytoplasm, cytoskeleton, spindle . Dynamic pattern of localization during the cell cycle. In most cells at interphase, present diffusely
Protein Description Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex. [PubMed: 11590237]
Protein Sequence MASFVTEVLAHSGRLEKEDLGTRISRLTRRVEEIKGEVCNMISKKYSEFLPSMQSAQGLITQVDKLSEDIDLLKSRIESEVRRDLHVSTGEFTDLKQQLERDSVVLSLLKQLQEFSTAIEEYNCALTEKKYVTGAQRLEEAQKCLKLLKSRKCFDLKILKSLSMELTIQKQNILYHLGEEWQKLIVWKFPPSKDTSSLESYLQTELHLYTEQSHKEEKTPMPPISSVLLAFSVLGELHSKLKSFGQMLLKYILRPLASCPSLHAVIESQPNIVIIRFESIMTNLEYPSPSEVFTKIRLVLEVLQKQLLDLPLDTDLENEKTSTVPLAEMLGDMIWEDLSECLIKNCLVYSIPTNSSKLQQYEEIIQSTEEFENALKEMRFLKGDTTDLLKYARNINSHFANKKCQDVIVAARNLMTSEIHNTVKIIPDSKINVPELPTPDEDNKLEVQKVSNTQYHEVMNLEPENTLDQHSFSLPTCRISESVKKLMELAYQTLLEATTSSDQCAVQLFYSVRNIFHLFHDVVPTYHKENLQKLPQLAAIHHNNCMYIAHHLLTLGHQFRLRLAPILCDGTATFVDLVPGFRRLGTECFLAQMRAQKGELLERLSSARNFSNMDDEENYSAASKAVRQVLHQLKRLGIVWQDVLPVNIYCKAMGTLLNTAISEVIGKITALEDISTEDGDRLYSLCKTVMDEGPQVFAPLSEESKNKKYQEEVPVYVPKWMPFKELMMMLQASLQEIGDRWADGKGPLAAAFSSSEVKALIRALFQNTERRAAALAKIK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MASFVTEVL
------CCHHHHHHH		16.2125944712
3Phosphorylation-----MASFVTEVLA
-----CCHHHHHHHH		20.9625159151
6Phosphorylation--MASFVTEVLAHSG
--CCHHHHHHHHHCC		20.5429255136
12PhosphorylationVTEVLAHSGRLEKED
HHHHHHHCCCCCHHH		21.7229255136
17UbiquitinationAHSGRLEKEDLGTRI
HHCCCCCHHHHHHHH		62.21-
17UbiquitinationAHSGRLEKEDLGTRI
HHCCCCCHHHHHHHH		62.21-
22PhosphorylationLEKEDLGTRISRLTR
CCHHHHHHHHHHHHH		31.9321406692
35AcetylationTRRVEEIKGEVCNMI
HHHHHHHHHHHHHHH		52.9125953088
43PhosphorylationGEVCNMISKKYSEFL
HHHHHHHHHHHHHHH		16.6023401153
74UbiquitinationSEDIDLLKSRIESEV
HHHHHHHHHHHHHHH		45.0121906983
74UbiquitinationSEDIDLLKSRIESEV
HHHHHHHHHHHHHHH		45.01-
88PhosphorylationVRRDLHVSTGEFTDL
HHHHCCCCCCCCCCH		21.6822199227
89PhosphorylationRRDLHVSTGEFTDLK
HHHCCCCCCCCCCHH		39.3722199227
96AcetylationTGEFTDLKQQLERDS
CCCCCCHHHHHHHHH		38.5226822725
96UbiquitinationTGEFTDLKQQLERDS
CCCCCCHHHHHHHHH		38.52-
96UbiquitinationTGEFTDLKQQLERDS
CCCCCCHHHHHHHHH		38.5221906983
103PhosphorylationKQQLERDSVVLSLLK
HHHHHHHHHHHHHHH		21.9821712546
107PhosphorylationERDSVVLSLLKQLQE
HHHHHHHHHHHHHHH		21.7524719451
129UbiquitinationYNCALTEKKYVTGAQ
HHCHHHCCHHCCHHH		44.1429967540
130UbiquitinationNCALTEKKYVTGAQR
HCHHHCCHHCCHHHH		38.43-
130UbiquitinationNCALTEKKYVTGAQR
HCHHHCCHHCCHHHH		38.4329967540
131PhosphorylationCALTEKKYVTGAQRL
CHHHCCHHCCHHHHH		17.8220068231
133PhosphorylationLTEKKYVTGAQRLEE
HHCCHHCCHHHHHHH		24.5720068231
143UbiquitinationQRLEEAQKCLKLLKS
HHHHHHHHHHHHHHH		48.89-
143UbiquitinationQRLEEAQKCLKLLKS
HHHHHHHHHHHHHHH		48.8924816145
162UbiquitinationDLKILKSLSMELTIQ
CHHHHHHHCCEEEEH		5.5924816145
170UbiquitinationSMELTIQKQNILYHL
CCEEEEHHHHHHHHC		41.2727667366
195PhosphorylationKFPPSKDTSSLESYL
ECCCCCCCCHHHHHH		24.7724043423
196PhosphorylationFPPSKDTSSLESYLQ
CCCCCCCCHHHHHHH		42.9624043423
197PhosphorylationPPSKDTSSLESYLQT
CCCCCCCHHHHHHHH		37.9424043423
200PhosphorylationKDTSSLESYLQTELH
CCCCHHHHHHHHHHH		36.1124043423
201PhosphorylationDTSSLESYLQTELHL
CCCHHHHHHHHHHHH		8.0824043423
204PhosphorylationSLESYLQTELHLYTE
HHHHHHHHHHHHHCC		37.6124043423
209PhosphorylationLQTELHLYTEQSHKE
HHHHHHHHCCCCCCC		9.4824043423
210PhosphorylationQTELHLYTEQSHKEE
HHHHHHHCCCCCCCC		33.6324043423
213PhosphorylationLHLYTEQSHKEEKTP
HHHHCCCCCCCCCCC		30.2324043423
264UbiquitinationASCPSLHAVIESQPN
HCCCCHHHHHHCCCC		14.8527667366
314O-linked_GlycosylationLLDLPLDTDLENEKT
HCCCCCCCCCCCCCC		50.6028411811
318UbiquitinationPLDTDLENEKTSTVP
CCCCCCCCCCCCCCC		64.4624816145
326UbiquitinationEKTSTVPLAEMLGDM
CCCCCCCHHHHHHHH		5.6827667366
349PhosphorylationLIKNCLVYSIPTNSS
HHHCCEEEECCCCHH		6.4722817900
353PhosphorylationCLVYSIPTNSSKLQQ
CEEEECCCCHHHHHH		46.1725627689
355PhosphorylationVYSIPTNSSKLQQYE
EEECCCCHHHHHHHH		31.1825627689
356PhosphorylationYSIPTNSSKLQQYEE
EECCCCHHHHHHHHH		39.1825627689
357UbiquitinationSIPTNSSKLQQYEEI
ECCCCHHHHHHHHHH		50.5729967540
361PhosphorylationNSSKLQQYEEIIQST
CHHHHHHHHHHHHCH		11.5427642862
376UbiquitinationEEFENALKEMRFLKG
HHHHHHHHHCHHHCC		47.2429967540
382UbiquitinationLKEMRFLKGDTTDLL
HHHCHHHCCCHHHHH		52.62-
382UbiquitinationLKEMRFLKGDTTDLL
HHHCHHHCCCHHHHH		52.6224816145
386PhosphorylationRFLKGDTTDLLKYAR
HHHCCCHHHHHHHHH		29.4119664994
390UbiquitinationGDTTDLLKYARNINS
CCHHHHHHHHHHCCH		44.13-
390UbiquitinationGDTTDLLKYARNINS
CCHHHHHHHHHHCCH		44.1327667366
402UbiquitinationINSHFANKKCQDVIV
CCHHHCCCCHHHHHH		52.0429967540
403UbiquitinationNSHFANKKCQDVIVA
CHHHCCCCHHHHHHH		36.6129967540
403UbiquitinationNSHFANKKCQDVIVA
CHHHCCCCHHHHHHH		36.61-
404UbiquitinationSHFANKKCQDVIVAA
HHHCCCCHHHHHHHH		4.4522817900
420UbiquitinationNLMTSEIHNTVKIIP
HCCCHHCCCCEEECC		21.6227667366
424UbiquitinationSEIHNTVKIIPDSKI
HHCCCCEEECCCCCC		32.6429967540
430UbiquitinationVKIIPDSKINVPELP
EEECCCCCCCCCCCC		45.7629967540
438PhosphorylationINVPELPTPDEDNKL
CCCCCCCCCCCCCCE		56.8730266825
444UbiquitinationPTPDEDNKLEVQKVS
CCCCCCCCEEEEEEC		59.3429967540
455PhosphorylationQKVSNTQYHEVMNLE
EEECCCCCEEECCCC		9.6322817900
484UbiquitinationCRISESVKKLMELAY
CCCCHHHHHHHHHHH		49.8527667366
560UbiquitinationLTLGHQFRLRLAPIL
HHHCCHHHHHCHHEE		16.6022817900
568GlutathionylationLRLAPILCDGTATFV
HHCHHEECCCCCCHH		4.7322555962
571PhosphorylationAPILCDGTATFVDLV
HHEECCCCCCHHHCC		14.8520071362
597UbiquitinationLAQMRAQKGELLERL
HHHHHHHHHHHHHHH		54.06-
597UbiquitinationLAQMRAQKGELLERL
HHHHHHHHHHHHHHH		54.06-
611PhosphorylationLSSARNFSNMDDEEN
HHHCCCCCCCCCHHH		34.4920860994
619PhosphorylationNMDDEENYSAASKAV
CCCCHHHHHHHHHHH		11.7220860994
624UbiquitinationENYSAASKAVRQVLH
HHHHHHHHHHHHHHH		46.2921906983
624UbiquitinationENYSAASKAVRQVLH
HHHHHHHHHHHHHHH		46.29-
6342-HydroxyisobutyrylationRQVLHQLKRLGIVWQ
HHHHHHHHHCCCEEE		38.72-
634AcetylationRQVLHQLKRLGIVWQ
HHHHHHHHHCCCEEE		38.7225953088
655PhosphorylationIYCKAMGTLLNTAIS
HHHHHHHHHHHHHHH		18.2620071362
659PhosphorylationAMGTLLNTAISEVIG
HHHHHHHHHHHHHHH		25.9020068231
662PhosphorylationTLLNTAISEVIGKIT
HHHHHHHHHHHHHHH		24.2820068231
684PhosphorylationEDGDRLYSLCKTVMD
CCCHHHHHHHHHHHC		31.7028348404
687UbiquitinationDRLYSLCKTVMDEGP
HHHHHHHHHHHCCCC		49.8229967540
688PhosphorylationRLYSLCKTVMDEGPQ
HHHHHHHHHHCCCCC		21.7728348404
690SulfoxidationYSLCKTVMDEGPQVF
HHHHHHHHCCCCCCC		4.7421406390
708UbiquitinationSEESKNKKYQEEVPV
CHHHCCCCCCCCCCC		62.6529967540
708AcetylationSEESKNKKYQEEVPV
CHHHCCCCCCCCCCC		62.6525953088
719AcetylationEVPVYVPKWMPFKEL
CCCCCCCCCCCHHHH		46.1925953088
777AcetylationRRAAALAKIK-----
HHHHHHHHCC-----		52.4519608861
777UbiquitinationRRAAALAKIK-----
HHHHHHHHCC-----		52.4519608861
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ZW10_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ZW10_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ZW10_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RINT1_HUMANRINT1physical
15029241
STX18_HUMANSTX18physical
15029241
A4_HUMANAPPphysical
21832049
KNTC1_HUMANKNTC1physical
15824131
ZWILC_HUMANZWILCHphysical
15824131
RINT1_HUMANRINT1physical
15824131
CS025_HUMANC19orf25physical
15824131
MD1L1_HUMANMAD1L1physical
15824131
MD2L1_HUMANMAD2L1physical
15824131
WASC5_HUMANKIAA0196physical
22863883
LMNA_HUMANLMNAphysical
22863883
PSD10_HUMANPSMD10physical
22863883
ROCK2_HUMANROCK2physical
22863883
ACTZ_HUMANACTR1Aphysical
26344197
ACTY_HUMANACTR1Bphysical
26344197
HSP74_HUMANHSPA4physical
26344197
KNTC1_HUMANKNTC1physical
26344197
MSH2_HUMANMSH2physical
26344197
STOM_HUMANSTOMphysical
27173435
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ZW10_HUMAN

loading...

Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-777, AND MASS SPECTROMETRY.
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of the human mitotic spindle.";
Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.;
Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-438, AND MASSSPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory