| UniProt ID | WASC5_HUMAN | |
|---|---|---|
| UniProt AC | Q12768 | |
| Protein Name | WASH complex subunit 5 {ECO:0000312|HGNC:HGNC:28984} | |
| Gene Name | WASHC5 {ECO:0000312|HGNC:HGNC:28984} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 1159 | |
| Subcellular Localization | Cytoplasm, cytosol . Endoplasmic reticulum . Early endosome . Colocalizes with SYP/synaptophysin in the external molecular layer of the dentate gyrus and in motoneurons of the ventral horn of spinal cord. | |
| Protein Description | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization, and which is involved in regulation of the fission of tubules that serve as transport intermediates during endosome sorting. [PubMed: 19922875] | |
| Protein Sequence | MLDFLAENNLCGQAILRIVSCGNAIIAELLRLSEFIPAVFRLKDRADQQKYGDIIFDFSYFKGPELWESKLDAKPELQDLDEEFRENNIEIVTRFYLAFQSVHKYIVDLNRYLDDLNEGVYIQQTLETVLLNEDGKQLLCEALYLYGVMLLVIDQKIEGEVRERMLVSYYRYSAARSSADSNMDDICKLLRSTGYSSQPGAKRPSNYPESYFQRVPINESFISMVIGRLRSDDIYNQVSAYPLPEHRSTALANQAAMLYVILYFEPSILHTHQAKMREIVDKYFPDNWVISIYMGITVNLVDAWEPYKAAKTALNNTLDLSNVREQASRYATVSERVHAQVQQFLKEGYLREEMVLDNIPKLLNCLRDCNVAIRWLMLHTADSACDPNNKRLRQIKDQILTDSRYNPRILFQLLLDTAQFEFILKEMFKQMLSEKQTKWEHYKKEGSERMTELADVFSGVKPLTRVEKNENLQAWFREISKQILSLNYDDSTAAGRKTVQLIQALEEVQEFHQLESNLQVCQFLADTRKFLHQMIRTINIKEEVLITMQIVGDLSFAWQLIDSFTSIMQESIRVNPSMVTKLRATFLKLASALDLPLLRINQANSPDLLSVSQYYSGELVSYVRKVLQIIPESMFTSLLKIIKLQTHDIIEVPTRLDKDKLRDYAQLGPRYEVAKLTHAISIFTEGILMMKTTLVGIIKVDPKQLLEDGIRKELVKRVAFALHRGLIFNPRAKPSELMPKLKELGATMDGFHRSFEYIQDYVNIYGLKIWQEEVSRIINYNVEQECNNFLRTKIQDWQSMYQSTHIPIPKFTPVDESVTFIGRLCREILRITDPKMTCHIDQLNTWYDMKTHQEVTSSRLFSEIQTTLGTFGLNGLDRLLCFMIVKELQNFLSMFQKIILRDRTVQDTLKTLMNAVSPLKSIVANSNKIYFSAIAKTQKIWTAYLEAIMKVGQMQILRQQIANELNYSCRFDSKHLAAALENLNKALLADIEAHYQDPSLPYPKEDNTLLYEITAYLEAAGIHNPLNKIYITTKRLPYFPIVNFLFLIAQLPKLQYNKNLGMVCRKPTDPVDWPPLVLGLLTLLKQFHSRYTEQFLALIGQFICSTVEQCTSQKIPEIPADVVGALLFLEDYVRYTKLPRRVAEAHVPNFIFDEFRTVL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 168 | Phosphorylation | VRERMLVSYYRYSAA HHHHHHHHHHHHHHH | 29083192 | ||
| 169 | Phosphorylation | RERMLVSYYRYSAAR HHHHHHHHHHHHHHH | 29083192 | ||
| 170 | Phosphorylation | ERMLVSYYRYSAARS HHHHHHHHHHHHHHH | 29083192 | ||
| 172 | Phosphorylation | MLVSYYRYSAARSSA HHHHHHHHHHHHHCC | 29083192 | ||
| 173 | Phosphorylation | LVSYYRYSAARSSAD HHHHHHHHHHHHCCC | 29083192 | ||
| 188 | Ubiquitination | SNMDDICKLLRSTGY CCHHHHHHHHHHCCC | - | ||
| 192 | Phosphorylation | DICKLLRSTGYSSQP HHHHHHHHCCCCCCC | 29978859 | ||
| 193 | Phosphorylation | ICKLLRSTGYSSQPG HHHHHHHCCCCCCCC | 29978859 | ||
| 195 | Phosphorylation | KLLRSTGYSSQPGAK HHHHHCCCCCCCCCC | 29978859 | ||
| 196 | Phosphorylation | LLRSTGYSSQPGAKR HHHHCCCCCCCCCCC | 29978859 | ||
| 197 | Phosphorylation | LRSTGYSSQPGAKRP HHHCCCCCCCCCCCC | 29978859 | ||
| 202 | Ubiquitination | YSSQPGAKRPSNYPE CCCCCCCCCCCCCCC | 21890473 | ||
| 224 | Sulfoxidation | INESFISMVIGRLRS CCHHHHHHHHHHCCC | 21406390 | ||
| 235 | Phosphorylation | RLRSDDIYNQVSAYP HCCCCCHHHHCCCCC | 27642862 | ||
| 311 | Ubiquitination | WEPYKAAKTALNNTL CCHHHHHHHHHHCCC | 21890473 | ||
| 346 | Ubiquitination | AQVQQFLKEGYLREE HHHHHHHHCCCCCHH | - | ||
| 354 | Sulfoxidation | EGYLREEMVLDNIPK CCCCCHHHHHHCHHH | 21406390 | ||
| 390 | Ubiquitination | SACDPNNKRLRQIKD CCCCCCCHHHHHHHH | - | ||
| 396 | Acetylation | NKRLRQIKDQILTDS CHHHHHHHHHHHCCC | 23954790 | ||
| 451 | Phosphorylation | KEGSERMTELADVFS HHHHHHHHHHHHHHC | - | ||
| 461 | Ubiquitination | ADVFSGVKPLTRVEK HHHHCCCCCCCCCCC | 21890473 | ||
| 464 | Phosphorylation | FSGVKPLTRVEKNEN HCCCCCCCCCCCCCC | - | ||
| 468 | Ubiquitination | KPLTRVEKNENLQAW CCCCCCCCCCCHHHH | - | ||
| 481 | Ubiquitination | AWFREISKQILSLNY HHHHHHHHHHHCCCC | 21890473 | ||
| 485 | Phosphorylation | EISKQILSLNYDDST HHHHHHHCCCCCCCC | 25262027 | ||
| 488 | Phosphorylation | KQILSLNYDDSTAAG HHHHCCCCCCCCHHH | 25262027 | ||
| 491 | Phosphorylation | LSLNYDDSTAAGRKT HCCCCCCCCHHHHHH | 25262027 | ||
| 492 | Phosphorylation | SLNYDDSTAAGRKTV CCCCCCCCHHHHHHH | 25262027 | ||
| 547 | Phosphorylation | IKEEVLITMQIVGDL CCCCCEEEEEECCCH | 22210691 | ||
| 555 | Phosphorylation | MQIVGDLSFAWQLID EEECCCHHHHHHHHH | 22210691 | ||
| 581 | Ubiquitination | VNPSMVTKLRATFLK CCHHHHHHHHHHHHH | 21890473 | ||
| 588 | Ubiquitination | KLRATFLKLASALDL HHHHHHHHHHHHCCC | 21890473 | ||
| 633 | Phosphorylation | VLQIIPESMFTSLLK HHHHCCHHHHHHHHH | 22210691 | ||
| 636 | Phosphorylation | IIPESMFTSLLKIIK HCCHHHHHHHHHHHH | 24043423 | ||
| 637 | Phosphorylation | IPESMFTSLLKIIKL CCHHHHHHHHHHHHH | 24719451 | ||
| 658 | Ubiquitination | EVPTRLDKDKLRDYA ECCCCCCHHHHHHHH | - | ||
| 660 | Ubiquitination | PTRLDKDKLRDYAQL CCCCCHHHHHHHHHH | - | ||
| 664 | Phosphorylation | DKDKLRDYAQLGPRY CHHHHHHHHHHCCHH | 27642862 | ||
| 671 | Phosphorylation | YAQLGPRYEVAKLTH HHHHCCHHHHHHHHH | - | ||
| 703 | Ubiquitination | GIIKVDPKQLLEDGI EEEECCHHHHHHCCH | - | ||
| 742 | Ubiquitination | SELMPKLKELGATMD HHHHHHHHHHCCCCC | 21890473 | ||
| 768 | Methylation | YVNIYGLKIWQEEVS HHHHHCHHHHHHHHH | - | ||
| 768 | "N6,N6-dimethyllysine" | YVNIYGLKIWQEEVS HHHHHCHHHHHHHHH | - | ||
| 793 | Ubiquitination | CNNFLRTKIQDWQSM HHHHHHHHHHHHHHH | - | ||
| 832 | Phosphorylation | CREILRITDPKMTCH HHHHHCCCCCCCEEE | 24719451 | ||
| 837 | Phosphorylation | RITDPKMTCHIDQLN CCCCCCCEEEHHHHC | - | ||
| 845 | Phosphorylation | CHIDQLNTWYDMKTH EEHHHHCCCCCCCCC | - | ||
| 847 | Phosphorylation | IDQLNTWYDMKTHQE HHHHCCCCCCCCCCH | - | ||
| 893 | Phosphorylation | KELQNFLSMFQKIIL HHHHHHHHHHHHHHH | - | ||
| 904 | Phosphorylation | KIILRDRTVQDTLKT HHHHCCCHHHHHHHH | 29449344 | ||
| 908 | Phosphorylation | RDRTVQDTLKTLMNA CCCHHHHHHHHHHHH | 29449344 | ||
| 910 | Ubiquitination | RTVQDTLKTLMNAVS CHHHHHHHHHHHHHH | - | ||
| 911 | Phosphorylation | TVQDTLKTLMNAVSP HHHHHHHHHHHHHHH | 23403867 | ||
| 917 | Phosphorylation | KTLMNAVSPLKSIVA HHHHHHHHHHHHHHC | 17160902 | ||
| 920 | Ubiquitination | MNAVSPLKSIVANSN HHHHHHHHHHHCCCC | - | ||
| 954 | Sulfoxidation | AIMKVGQMQILRQQI HHHHHHHHHHHHHHH | 21406390 | ||
| 974 | Ubiquitination | YSCRFDSKHLAAALE CCCCCCHHHHHHHHH | 21906983 | ||
| 974 | Sumoylation | YSCRFDSKHLAAALE CCCCCCHHHHHHHHH | - | ||
| 995 | Phosphorylation | LADIEAHYQDPSLPY HHHHHHHCCCCCCCC | 25627689 | ||
| 1058 | Ubiquitination | LPKLQYNKNLGMVCR CCCCCCCCCCCCCCC | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of WASC5_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of WASC5_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of WASC5_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| WASC4_HUMAN | KIAA1033 | physical | 20923837 | |
| WAC2C_HUMAN | FAM21C | physical | 20923837 | |
| WASH1_HUMAN | WASH1 | physical | 20923837 | |
| WASH1_HUMAN | WASH1 | physical | 22939629 | |
| FKB15_HUMAN | FKBP15 | physical | 20376207 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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