| UniProt ID | WASC4_HUMAN | |
|---|---|---|
| UniProt AC | Q2M389 | |
| Protein Name | WASH complex subunit 4 {ECO:0000312|HGNC:HGNC:29174} | |
| Gene Name | WASHC4 {ECO:0000312|HGNC:HGNC:29174} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 1173 | |
| Subcellular Localization | Early endosome . | |
| Protein Description | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization, and which is involved in the regulation of the fission of tubules that serve as transport intermediates during endosome sorting. [PubMed: 19922875] | |
| Protein Sequence | MAVETLSPDWEFDRVDDGSQKIHAEVQLKNYGKFLEEYTSQLRRIEDALDDSIGDVWDFNLDPIALKLLPYEQSSLLELIKTENKVLNKVITVYAALCCEIKKLKYEAETKFYNGLLFYGEGATDASMVEGDCQIQMGRFISFLQELSCFVTRCYEVVMNVVHQLAALYISNKIAPKIIETTGVHFQTMYEHLGELLTVLLTLDEIIDNHITLKDHWTMYKRLLKSVHHNPSKFGIQEEKLKPFEKFLLKLEGQLLDGMIFQACIEQQFDSLNGGVSVSKNSTFAEEFAHSIRSIFANVEAKLGEPSEIDQRDKYVGICGLFVLHFQIFRTIDKKFYKSLLDICKKVPAITLTANIIWFPDNFLIQKIPAAAKLLDRKSLQAIKIHRDTFLQQKAQSLTKDVQSYYVFVSSWMMKMESILSKEQRMDKFAEDLTNRCNVFIQGFLYAYSISTIIKTTMNLYMSMQKPMTKTSVKALCRLVELLKAIEHMFYRRSMVVADSVSHITQHLQHQALHSISVAKKRVISDKKYSEQRLDVLSALVLAENTLNGPSTKQRRLIVSLALSVGTQMKTFKDEELFPLQVVMKKLDLISELRERVQTQCDCCFLYWHRAVFPIYLDDVYENAVDAARLHYMFSALRDCVPAMMHARHLESYEILLDCYDKEIMEILNEHLLDKLCKEIEKDLRLSVHTHLKLDDRNPFKVGMKDLALFFSLNPIRFFNRFIDIRAYVTHYLDKTFYNLTTVALHDWATYSEMRNLATQRYGLVMTEAHLPSQTLEQGLDVLEIMRNIHIFVSRYLYNLNNQIFIERTSNNKHLNTINIRHIANSIRTHGTGIMNTTVNFTYQFLKKKFYIFSQFMYDEHIKSRLIKDIRFFREIKDQNDHKYPFDRAEKFNRGIRKLGVTPEGQSYLDQFRQLISQIGNAMGYVRMIRSGGLHCSSNAIRFVPDLEDIVNFEELVKEEGLAEETLKAARHLDSVLSDHTRNSAEGTEYFKMLVDVFAPEFRRPKNIHLRNFYIIVPPLTLNFVEHSISCKEKLNKKNKIGAAFTDDGFAMGVAYILKLLDQYREFDSLHWFQSVREKYLKEIRAVAKQQNVQSASQDEKLLQTMNLTQKRLDVYLQEFELLYFSLSSARIFFRADKTAAEENQEKKEKEEETKTSNGDLSDSTVSADPVVK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MAVETLSPD ------CCCCCCCCC | 20068231 | ||
| 5 | Phosphorylation | ---MAVETLSPDWEF ---CCCCCCCCCCCE | 22199227 | ||
| 7 | Phosphorylation | -MAVETLSPDWEFDR -CCCCCCCCCCCEEE | 28355574 | ||
| 19 | Phosphorylation | FDRVDDGSQKIHAEV EEECCCCCCEEEEEE | 26074081 | ||
| 21 | Ubiquitination | RVDDGSQKIHAEVQL ECCCCCCEEEEEEEH | - | ||
| 29 | Methylation | IHAEVQLKNYGKFLE EEEEEEHHHHHHHHH | 23644510 | ||
| 29 | Ubiquitination | IHAEVQLKNYGKFLE EEEEEEHHHHHHHHH | 21906983 | ||
| 29 (in isoform 1) | Ubiquitination | - | 21906983 | ||
| 29 (in isoform 2) | Ubiquitination | - | 21906983 | ||
| 33 | Ubiquitination | VQLKNYGKFLEEYTS EEHHHHHHHHHHHHH | - | ||
| 33 | Methylation | VQLKNYGKFLEEYTS EEHHHHHHHHHHHHH | 23644510 | ||
| 38 | Phosphorylation | YGKFLEEYTSQLRRI HHHHHHHHHHHHHHH | 25159151 | ||
| 81 | Ubiquitination | SSLLELIKTENKVLN HHHHHHHHHCCHHHH | - | ||
| 119 | Phosphorylation | FYNGLLFYGEGATDA EECCEEEECCCCCCH | 22817900 | ||
| 155 | Phosphorylation | SCFVTRCYEVVMNVV HHHHHHHHHHHHHHH | 22817900 | ||
| 169 | Phosphorylation | VHQLAALYISNKIAP HHHHHHHHHHCCCCC | 22817900 | ||
| 225 | Ubiquitination | TMYKRLLKSVHHNPS HHHHHHHHHHCCCHH | - | ||
| 233 | Ubiquitination | SVHHNPSKFGIQEEK HHCCCHHHCCCCHHH | 21906983 | ||
| 233 (in isoform 1) | Ubiquitination | - | 21906983 | ||
| 233 (in isoform 2) | Ubiquitination | - | 21906983 | ||
| 240 | Ubiquitination | KFGIQEEKLKPFEKF HCCCCHHHCCCHHHH | - | ||
| 302 | Ubiquitination | IFANVEAKLGEPSEI HHHCHHHHCCCCCHH | 21906983 | ||
| 302 (in isoform 1) | Ubiquitination | - | 21906983 | ||
| 302 (in isoform 2) | Ubiquitination | - | 21906983 | ||
| 373 | Acetylation | QKIPAAAKLLDRKSL HHCHHHHHHCCHHHH | 25953088 | ||
| 373 | Malonylation | QKIPAAAKLLDRKSL HHCHHHHHHCCHHHH | 32601280 | ||
| 373 | Ubiquitination | QKIPAAAKLLDRKSL HHCHHHHHHCCHHHH | - | ||
| 378 | Ubiquitination | AAKLLDRKSLQAIKI HHHHCCHHHHHHHHH | - | ||
| 384 | Ubiquitination | RKSLQAIKIHRDTFL HHHHHHHHHCHHHHH | - | ||
| 394 (in isoform 1) | Ubiquitination | - | 21906983 | ||
| 394 (in isoform 2) | Ubiquitination | - | 21906983 | ||
| 394 | Ubiquitination | RDTFLQQKAQSLTKD HHHHHHHHHHHCCHH | 21906983 | ||
| 405 | Phosphorylation | LTKDVQSYYVFVSSW CCHHHHHHHHHHHHH | - | ||
| 406 | Phosphorylation | TKDVQSYYVFVSSWM CHHHHHHHHHHHHHH | - | ||
| 418 | Phosphorylation | SWMMKMESILSKEQR HHHHHHHHHHCHHHH | 24719451 | ||
| 422 (in isoform 1) | Ubiquitination | - | 21906983 | ||
| 422 | Ubiquitination | KMESILSKEQRMDKF HHHHHHCHHHHHHHH | 21906983 | ||
| 422 (in isoform 2) | Ubiquitination | - | 21906983 | ||
| 461 | Phosphorylation | IKTTMNLYMSMQKPM HHHHHHHHHHCCCCC | 19835603 | ||
| 474 | Ubiquitination | PMTKTSVKALCRLVE CCCHHHHHHHHHHHH | - | ||
| 491 | Phosphorylation | KAIEHMFYRRSMVVA HHHHHHHHHCHHHHH | - | ||
| 494 | Phosphorylation | EHMFYRRSMVVADSV HHHHHHCHHHHHHHH | - | ||
| 500 | Phosphorylation | RSMVVADSVSHITQH CHHHHHHHHHHHHHH | - | ||
| 546 | Phosphorylation | ALVLAENTLNGPSTK HHHHHHHCCCCCCHH | 26074081 | ||
| 551 | Phosphorylation | ENTLNGPSTKQRRLI HHCCCCCCHHHHHHH | 26074081 | ||
| 552 | Phosphorylation | NTLNGPSTKQRRLIV HCCCCCCHHHHHHHH | 26074081 | ||
| 553 (in isoform 2) | Ubiquitination | - | 21906983 | ||
| 553 | Ubiquitination | TLNGPSTKQRRLIVS CCCCCCHHHHHHHHH | 21906983 | ||
| 554 (in isoform 1) | Ubiquitination | - | 21906983 | ||
| 560 | Phosphorylation | KQRRLIVSLALSVGT HHHHHHHHHHHHHCC | 26074081 | ||
| 564 | Phosphorylation | LIVSLALSVGTQMKT HHHHHHHHHCCCCCC | 26074081 | ||
| 567 | Phosphorylation | SLALSVGTQMKTFKD HHHHHHCCCCCCCCC | 20068231 | ||
| 571 | Phosphorylation | SVGTQMKTFKDEELF HHCCCCCCCCCCCCH | 26074081 | ||
| 573 (in isoform 2) | Ubiquitination | - | 21906983 | ||
| 573 | Ubiquitination | GTQMKTFKDEELFPL CCCCCCCCCCCCHHH | 21906983 | ||
| 574 (in isoform 1) | Ubiquitination | - | 21906983 | ||
| 585 (in isoform 2) | Ubiquitination | - | 21906983 | ||
| 585 | Ubiquitination | FPLQVVMKKLDLISE HHHHHHHHHHHHHHH | 21906983 | ||
| 586 (in isoform 1) | Ubiquitination | - | 21906983 | ||
| 586 | Ubiquitination | PLQVVMKKLDLISEL HHHHHHHHHHHHHHH | - | ||
| 586 | 2-Hydroxyisobutyrylation | PLQVVMKKLDLISEL HHHHHHHHHHHHHHH | - | ||
| 586 | Malonylation | PLQVVMKKLDLISEL HHHHHHHHHHHHHHH | 26320211 | ||
| 591 | Phosphorylation | MKKLDLISELRERVQ HHHHHHHHHHHHHHH | 24719451 | ||
| 701 | Ubiquitination | LDDRNPFKVGMKDLA CCCCCCCCCCCCHHH | - | ||
| 813 (in isoform 2) | Ubiquitination | - | 21906983 | ||
| 813 | Ubiquitination | IERTSNNKHLNTINI EEECCCCCCCEEEEH | 21906983 | ||
| 814 (in isoform 1) | Ubiquitination | - | 21906983 | ||
| 826 (in isoform 2) | Phosphorylation | - | 22210691 | ||
| 826 | Phosphorylation | NIRHIANSIRTHGTG EHHHHHHHHHHCCCC | 20068231 | ||
| 829 (in isoform 2) | Phosphorylation | - | 20068231 | ||
| 832 (in isoform 2) | Phosphorylation | - | 20068231 | ||
| 837 (in isoform 2) | Phosphorylation | - | 22210691 | ||
| 838 (in isoform 2) | Phosphorylation | - | 22210691 | ||
| 877 | Ubiquitination | IRFFREIKDQNDHKY HHHHHHHHCCCCCCC | - | ||
| 883 | Ubiquitination | IKDQNDHKYPFDRAE HHCCCCCCCCCCHHH | - | ||
| 925 | Phosphorylation | QIGNAMGYVRMIRSG HHHHHHHHHHHHHCC | 22210691 | ||
| 931 | Phosphorylation | GYVRMIRSGGLHCSS HHHHHHHCCCCEECC | 22210691 | ||
| 937 | Phosphorylation | RSGGLHCSSNAIRFV HCCCCEECCCEEEEC | - | ||
| 968 | Ubiquitination | GLAEETLKAARHLDS CCHHHHHHHHHHHHH | 21906983 | ||
| 969 (in isoform 1) | Ubiquitination | - | 21906983 | ||
| 975 | Phosphorylation | KAARHLDSVLSDHTR HHHHHHHHHHCCCCC | 23312004 | ||
| 978 | Phosphorylation | RHLDSVLSDHTRNSA HHHHHHHCCCCCCCH | 23312004 | ||
| 981 | Phosphorylation | DSVLSDHTRNSAEGT HHHHCCCCCCCHHCH | 23312004 | ||
| 1082 | Ubiquitination | SVREKYLKEIRAVAK HHHHHHHHHHHHHHH | - | ||
| 1089 | Ubiquitination | KEIRAVAKQQNVQSA HHHHHHHHHHCCCCC | 2190698 | ||
| 1090 (in isoform 1) | Ubiquitination | - | 21906983 | ||
| 1097 | Phosphorylation | QQNVQSASQDEKLLQ HHCCCCCCHHHHHHH | 25159151 | ||
| 1101 | Ubiquitination | QSASQDEKLLQTMNL CCCCHHHHHHHHCCC | - | ||
| 1109 | Phosphorylation | LLQTMNLTQKRLDVY HHHHCCCCHHHHHHH | - | ||
| 1111 | Ubiquitination | QTMNLTQKRLDVYLQ HHCCCCHHHHHHHHH | - | ||
| 1154 | Phosphorylation | KKEKEEETKTSNGDL HHHHHHHHCCCCCCC | 23401153 | ||
| 1156 | Phosphorylation | EKEEETKTSNGDLSD HHHHHHCCCCCCCCC | 23401153 | ||
| 1157 | Phosphorylation | KEEETKTSNGDLSDS HHHHHCCCCCCCCCC | 23401153 | ||
| 1162 | Phosphorylation | KTSNGDLSDSTVSAD CCCCCCCCCCCCCCC | 23927012 | ||
| 1164 | Phosphorylation | SNGDLSDSTVSADPV CCCCCCCCCCCCCCC | 25159151 | ||
| 1165 | Phosphorylation | NGDLSDSTVSADPVV CCCCCCCCCCCCCCC | 23927012 | ||
| 1167 | Phosphorylation | DLSDSTVSADPVVK- CCCCCCCCCCCCCC- | 23403867 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of WASC4_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of WASC4_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of WASC4_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| WASH1_HUMAN | WASH1 | physical | 20923837 | |
| WASC5_HUMAN | KIAA0196 | physical | 22939629 | |
| WASH1_HUMAN | WASH1 | physical | 22939629 | |
| WASC5_HUMAN | KIAA0196 | physical | 22863883 | |
| ROCK1_HUMAN | ROCK1 | physical | 22863883 | |
| UBP34_HUMAN | USP34 | physical | 22863883 | |
| WDHD1_HUMAN | WDHD1 | physical | 22863883 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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